Chimeric Human Immunodeficiency Virus Type 1 Virions That Contain the Simian Immunodeficiency Virus nef Gene Are Cyclosporin A Resistant
2005 ◽
Vol 79
(5)
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pp. 3211-3216
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Keyword(s):
ABSTRACT We have previously shown that human immunodeficiency virus type 1 (HIV-1) virions which have their own nef gene deleted and are trans complemented to contain HIV-2 or simian immunodeficiency virus (SIV) Nef become resistant to treatment with cyclosporin A. To expand and confirm these studies, we have tested an HIV-1 isolate in which the HIV-1 nef gene has been replaced by the nef gene from SIV in a multiround infectivity assay using more physiologically relevant cell types. Our results confirm that HIV-1 virions that contain SIV nef can replicate in a cyclophilin-independent fashion.
2003 ◽
Vol 77
(17)
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pp. 9295-9304
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2003 ◽
Vol 47
(5)
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pp. 1756-1759
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1988 ◽
Vol 32
(11)
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pp. 1733-1734
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2003 ◽
Vol 77
(15)
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pp. 8237-8248
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2004 ◽
Vol 48
(9)
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pp. 3483-3490
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1989 ◽
Vol 11
(6)
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pp. 353-359
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2004 ◽
Vol 78
(4)
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pp. 1843-1850
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1998 ◽
Vol 72
(10)
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pp. 7934-7940
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