scholarly journals SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

2012 ◽  
Vol 32 (14) ◽  
pp. 2653-2663 ◽  
Author(s):  
N. Sharma ◽  
V. Kumar ◽  
S. Everingham ◽  
R. S. Mali ◽  
R. Kapur ◽  
...  
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Cell Survival ◽  
Sh2 Domain ◽  
Tissue Mast Cell

scholarly journals Studies of connective tissue mast cell-mediated cytotoxicity

1989 ◽  
Vol 93 (3) ◽  
pp. 423-428 ◽  
Author(s):  
Michael D. Tharp ◽  
Candace Kasper ◽  
Dwain Thiele ◽  
Michael R. Charley ◽  
Donald A. Kennerly ◽  
...  
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Tissue Mast Cell

scholarly journals Genome-Wide Transcriptional Profiling Reveals Connective Tissue Mast Cell Accumulation in Bronchopulmonary Dysplasia

2012 ◽  
Vol 186 (4) ◽  
pp. 349-358 ◽  
Author(s):  
Soumyaroop Bhattacharya ◽  
Diana Go ◽  
Daria L. Krenitsky ◽  
Heidi L. Huyck ◽  
Siva Kumar Solleti ◽  
...  
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Bronchopulmonary Dysplasia ◽  
Transcriptional Profiling ◽  
Tissue Mast Cell ◽  
Genome Wide ◽  
Cell Accumulation

Extracellular Localization of Human Connective Tissue Mast Cell Granule Contents

1990 ◽  
Vol 96 (6) ◽  
pp. 857-863 ◽  
Author(s):  
Michael S. Kaminer ◽  
Robert M. Lavker ◽  
Laurence J. Walsh ◽  
Diana. Whitaker ◽  
Burton. Zweiman
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Cell Granule ◽  
Tissue Mast Cell ◽  
Mast Cell Granule

scholarly journals Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

2021 ◽  
Vol 22 (23) ◽  
pp. 12627
Author(s):  
Zhirong Fu ◽  
Srinivas Akula ◽  
Anna-Karin Olsson ◽  
Jukka Kervinen ◽  
Lars Hellman
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Blood Feeding ◽  
Cathepsin G ◽  
Human Mast Cell ◽  
Mucosal Mast Cell ◽  
Tissue Mast Cell ◽  
Tick Feeding

Ticks, lice, flees, mosquitos, leeches and vampire bats need to prevent the host’s blood coagulation during their feeding process. This is primarily achieved by injecting potent anticoagulant proteins. Basophils frequently accumulate at the site of tick feeding. However, this occurs only after the second encounter with the parasite involving an adaptive immune response and IgE. To study the potential role of basophils and mast cells in the defense against ticks and other ectoparasites, we produced anticoagulant proteins from three blood-feeding animals; tick, mosquito, and leech. We tested these anticoagulant proteins for their sensitivity to inactivation by a panel of hematopoietic serine proteases. The majority of the connective tissue mast cell proteases tested, originating from humans, dogs, rats, hamsters, and opossums, efficiently cleaved these anticoagulant proteins. Interestingly, the mucosal mast cell proteases that contain closely similar cleavage specificity, had little effect on these anticoagulant proteins. Ticks have been shown to produce serpins, serine protease inhibitors, upon a blood meal that efficiently inhibit the human mast cell chymase and cathepsin G, indicating that ticks have developed a strategy to inactivate these proteases. We show here that one of these tick serpins (IRS-2) shows broad activity against the majority of the mast cell chymotryptic enzymes and the neutrophil proteases from human to opossum. However, it had no effect on the mast cell tryptases or the basophil specific protease mMCP-8. The production of anticoagulants, proteases and anti-proteases by the parasite and the host presents a fascinating example of an arms race between the blood-feeding animals and the mammalian immune system with an apparent and potent role of the connective tissue mast cell chymases in the host defense.

scholarly journals A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

2019 ◽  
Vol 26 (1) ◽  
pp. 114-122.e8 ◽  
Author(s):  
Priyanka Pundir ◽  
Rui Liu ◽  
Chirag Vasavda ◽  
Nadine Serhan ◽  
Nathachit Limjunyawong ◽  
...  
Keyword(s):  
Mast Cell ◽  
Quorum Sensing ◽  
Connective Tissue ◽  
Specific Receptor ◽  
Tissue Mast Cell ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Catabolism of IgE by rat mucosal and connective tissue mast cell chymases

1990 ◽  
pp. 420-423 ◽  
Author(s):  
A McGuigan ◽  
G F J Newlands ◽  
R G Woodbury ◽  
H R P Miller
Keyword(s):  
Mast Cell ◽  
Connective Tissue ◽  
Tissue Mast Cell

An improved method for staining mouse mast cells

1989 ◽  
Vol 67 (1) ◽  
pp. 226-227 ◽  
Author(s):  
M. Novak ◽  
S. Nombrado
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Alcian Blue ◽  
Cell Types ◽  
Mucosal Mast Cell ◽  
Improved Method ◽  
Tissue Mast Cell ◽  
Pathological Conditions

An improved method for staining mouse mast cells with alcian blue is reported. The reaction differentiates between mucosal mast cell and connective tissue mast cell types, especially under pathological conditions.

Reduction of ethanol-induced gastric damage by sodium cromoglycate and FPL-52694. Role of leukotrienes, prostaglandins, and mast cells in the protective mechanism

1989 ◽  
Vol 67 (4) ◽  
pp. 287-293 ◽  
Author(s):  
Paul L. Beck ◽  
Gerald P. Morris ◽  
John L. Wallace
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Sodium Cromoglycate ◽  
Mechanism Of Action ◽  
Gastric Damage ◽  
Gastric Mucosal Damage ◽  
Tissue Mast Cell ◽  
Cell Numbers ◽  
Two Agents

The mechanism of action of the "mast cell stabilizers" sodium cromoglycate and FPL-52694 as protective agents against ethanol-induced gastric mucosal damage was investigated in the rat. Using an ex vivo gastric chamber model, various concentrations (10–80 mg/mL) of the two agents were applied to the gastric mucosa prior to exposure to 40% ethanol. Both agents significantly reduced ethanol-induced damage in a dose-dependent manner. When given orally (80 mg/kg) both agents significantly reduced gastric damage induced by subsequent oral administration of absolute ethanol. Pretreatment with indomethacin did not significantly affect the protection afforded by FPL-52694, but did cause a partial reversal of the protective effect of sodium cromoglycate. Changes in gastric leukotriene C4 synthesis did not correlate with the protective effects of the two agents. Both mucosal and connective tissue mast cell numbers were significantly reduced following oral ethanol administration. In the groups pretreated with FPL-52694 or sodium cromoglycate, mucosal mast cell numbers were not significantly different from those in rats not treated with ethanol. Furthermore, the connective tissue mast cell numbers were significantly lower than in ethanol-treated control rats, despite a >95% reduction of ethanol-induced hemorrhagic damage. These results therefore suggest that stimulation of gastric prostaglandin synthesis is not important in the mechanism of action of FPL-52694, and neither agent appears to reduce damage through a mechanism related to effects on gastric leukotriene C4 synthesis. The present studies further suggest that the protection afforded by pretreatment with sodium cromoglycate or FPL-52694 may be unrelated to effects of these agents on the connective tissue mast cell population in the stomach.Key words: ulcer, eicosanoids, mast cells, alcohol, mast cell stabilizers.

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