Mutation in H1N1 Pandemic Virus Changes Receptor Specificity and Cell Tropism—also Associated with 1918 Pandemic

2010 ◽  
Vol 5 (12) ◽  
pp. 526-526
Keyword(s):  
H1n1 Pandemic ◽  
Cell Tropism ◽  
Receptor Specificity ◽  
Pandemic Virus

scholarly journals Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia

2014 ◽  
Vol 29 (4) ◽  
pp. 242-249 ◽  
Author(s):  
Luisa Fernanda Mancipe Jiménez ◽  
Gloria Ramírez Nieto ◽  
Victor Vera Alfonso ◽  
Jairo Jaime Correa
Keyword(s):  
Respiratory Disease ◽  
Swine Influenza ◽  
H1n1 Pandemic ◽  
Disease Complex ◽  
Pandemic Virus ◽  
Pig Farms ◽  
Porcine Respiratory Disease Complex ◽  
Porcine Respiratory ◽  
Influenza H1n1

scholarly journals Sequence Analysis of In Vivo Defective Interfering-Like RNA of Influenza A H1N1 Pandemic Virus

2013 ◽  
Vol 87 (14) ◽  
pp. 8064-8074 ◽  
Author(s):  
K. Saira ◽  
X. Lin ◽  
J. V. DePasse ◽  
R. Halpin ◽  
A. Twaddle ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Influenza A ◽  
H1n1 Pandemic ◽  
Pandemic Virus ◽  
Influenza A H1n1

scholarly journals Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England

2013 ◽  
Vol 110 (33) ◽  
pp. 13422-13427 ◽  
Author(s):  
I. Dorigatti ◽  
S. Cauchemez ◽  
N. M. Ferguson
Keyword(s):  
Third Wave ◽  
H1n1 Pandemic ◽  
The Third ◽  
Pandemic Virus ◽  
2009 H1n1

scholarly journals Does Pandemic A/H1N1 Virus Have the Potential To Become More Pathogenic?

mBio ◽  
2010 ◽  
Vol 1 (5) ◽  
Author(s):  
Natalia A. Ilyushina ◽  
Mariette F. Ducatez ◽  
Jerold E. Rehg ◽  
Bindumadhav M. Marathe ◽  
Henju Marjuki ◽  
...  
Keyword(s):  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Polymerase Activity ◽  
Acidic Protein ◽  
Progeny Virus ◽  
H1n1 Pandemic ◽  
Future Evolution ◽  
Pandemic Strain ◽  
Pandemic Virus ◽  
Pandemic Strains

ABSTRACT Epidemiologic observations that have been made in the context of the current pandemic influenza virus include a stable virulence phenotype and a lack of propensity to reassort with seasonal strains. In an attempt to determine whether either of these observations could change in the future, we coinfected differentiated human airway cells with seasonal oseltamivir-resistant A/New Jersey/15/07 and pandemic A/Tennessee/1-560/09 (H1N1) viruses in three ratios (10:90, 50:50, and 90:10) and examined the resulting progeny viruses after 10 sequential passages. When the pandemic virus was initially present at multiplicities of infection equal to or greater than those for the seasonal virus, only pandemic virus genotypes were detected. These adapted pandemic strains did, however, contain two nonsynonymous mutations (hemagglutinin K154Q and polymerase acidic protein L295P) that conferred a more virulent phenotype, both in cell cultures and in ferrets, than their parental strains. The polymerase acidic protein mutation increased polymerase activity at 37°C, and the hemagglutinin change affected binding of the virus to α2,6-sialyl receptors. When the seasonal A/H1N1 virus was initially present in excess, the dominant progeny virus was a reassortant containing the hemagglutinin gene from the seasonal strain and the remaining genes from the pandemic virus. Our study demonstrates that the emergence of an A/H1N1 pandemic strain of higher virulence is possible and that, despite their lack of detection thus far in humans, viable seasonal/pandemic virus reassortants can be generated. IMPORTANCE This report supplies a key piece of information for investigating future evolution scenarios of pandemic A/H1N1 influenza in the human population. We report that the emergence of an A/H1N1 pandemic strain of higher virulence is possible and that, despite their lack of detection thus far in humans, viable seasonal/pandemic virus reassortants can be generated.

scholarly journals The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009

2010 ◽  
Vol 15 (14) ◽  
Author(s):  
H Harvala ◽  
R Gunson ◽  
P Simmonds ◽  
A Hardie ◽  
S Bennett ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Pandemic ◽  
Immunocompromised Patients ◽  
Rt Pcr ◽  
Oseltamivir Resistance ◽  
Pandemic Virus ◽  
Hospitalised Patients ◽  
Influenza A H1n1 ◽  
H275y Mutation

To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.

scholarly journals Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype?

2010 ◽  
Vol 6 (10) ◽  
pp. e1001145 ◽  
Author(s):  
Jianqiang Ye ◽  
Erin M. Sorrell ◽  
Yibin Cai ◽  
Hongxia Shao ◽  
Kemin Xu ◽  
...  
Keyword(s):  
H1n1 Pandemic ◽  
Virulence Phenotype ◽  
Pandemic Virus ◽  
2009 H1n1
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