scholarly journals Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components Ex Vivo : The Knee Explant Analysis (KnEA) Study

2021 ◽  
Author(s):  
David Huang ◽  
Dana Parker ◽  
Jonathan B. Mandell ◽  
Kimberly M. Brothers ◽  
Charles G. Gish ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Antimicrobial Peptide ◽  
Knee Arthroplasty ◽  
Prosthetic Joint Infection ◽  
Ex Vivo ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
Total Knee ◽  
Explant Analysis ◽  
Number Of Bacteria

Chronically infected prosthetics of the knee were exposed to PLG0206, an engineered antimicrobial peptide, at a concentration of 1 mg/mL for 15 min. Consequently, a mean 4-log 10 reduction (range, 1 to 7) in the number of bacteria occurred, which may translate to improved clinical outcomes for persons with prosthetic joint infection of the knee.

Lyme Prosthetic Joint Infection in Total Knee Arthroplasty

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
Muzaffar Ali ◽  
Anthony O. Kamson ◽  
Nadia Hussain ◽  
Scott G. King
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
Total Knee

scholarly journals Fungal Prosthetic Joint Infection Following Total Knee Arthroplasty: A Case Report

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Baraa W Mafrachi ◽  
Ashraf H Al Debei ◽  
Farah M Al Muhtaseb ◽  
Jihad M Al Ajlouni ◽  
Yazan S Hammad
Keyword(s):  
Total Knee Arthroplasty ◽  
Case Report ◽  
Total Knee Replacement ◽  
Knee Replacement ◽  
Knee Arthroplasty ◽  
Prosthetic Joint Infection ◽  
Rare Complication ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
Total Knee

Introduction: Prosthetic joint infection (PJI) is a rare complication of total knee replacement (TKR), yet it is a serious and debilitating condition. Bacterial infection accounts for the majority of cases and fungal infection is estimated to cause 1% of all prosthesis infection. Case Report: This case presents a 60years female, who presented to our outpatient orthopedic clinic complaining of right knee pain, swelling, and hotness. The physical examination revealed redness, hotness, restricted range of movement, and tibial loosening, 9 months following TKR revision. Culture of the joint aspirate showed growth of “Candida parapsilosis” and second aspirate confirmed the diagnosis. The patient then underwent two stages revision surgery with placement of amphotericin B loaded cement, to maintain high local antifungal concentration in addition to decrease the side effects of amphotericinB infusion such as thrombophlebitis and the more serious systemic effect as nephrotoxicity. The post-operative course was uneventful, with gradual improvement and restoration of normal movement range. Conclusion: Fungal PJI is a rare complication of TKR, yet it results in severe debilitating symptoms and impairment of the patient functional capacity. Careful evaluation of the patient followed by a detailed workup is necessary for the identification of the underlying causative micro-organism. Two-stage revision surgery with antifungal loaded cement spacer and antifungal therapy currently is the standard of management. To the best of our knowledge, this is the first fungal PJI following total knee arthroplasty reported in Jordan. Keywords: Fungal prosthetic joint infection, fungal infection, total knee replacement, total knee replacement complication.

scholarly journals Fungal prosthetic joint infection after total knee arthroplasty

2013 ◽  
Vol 47 (5) ◽  
pp. 526 ◽  
Author(s):  
KankanalaJ Reddy ◽  
JayD Shah ◽  
RohitV Kale ◽  
TJayakrishna Reddy
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
Total Knee
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