Purpose. To present the model of tectonic development of the Irtysh shear zone, based on recent uranium-lead dating for zircon. Methodology. The authors analyzed the results of studies of foreign and domestic scientists, conducted field research, sample preparation, carried out iso-tope studies using SHRIMP-2 and LA-ICP-MS technology; determined small elements by the fusion method using ICP. Findings. Based on more than ten uranium-lead dating for zircon using the local method and the given geological and structural data, model of the Irtysh shear zone tectonic development has been proposed Originality. A tectonic model has been developed and the age and structural relationships of the Irtysh shear zone with the Kalba-Narym zone based on uranium-lead zircon dating have been established. Practical value. The article considers the structural and age relationships of the Irtysh crush zone which prove its formation along the deep Irtysh fault in the course of a long multi-stage tectogenesis.