Dinitrosyl Iron Complexes with Glutathione Ligands Intercept Peroxynitrite and Protect Hemoglobin from Oxidative Modification

2021 ◽  
Vol 57 (4) ◽  
pp. 411-420
Author(s):  
O. V. Kosmachevskaya ◽  
E. I. Nasybullina ◽  
K. B. Shumaev ◽  
L. V. Chumikina ◽  
L. I. Arabova ◽  
...  
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Oxidative Modification ◽  
Dinitrosyl Iron

scholarly journals Protective Effect of Dinitrosyl Iron Complexes Bound with Hemoglobin on Oxidative Modification by Peroxynitrite

2021 ◽  
Vol 22 (24) ◽  
pp. 13649
Author(s):  
Olga V. Kosmachevskaya ◽  
Elvira I. Nasybullina ◽  
Konstantin B. Shumaev ◽  
Natalia N. Novikova ◽  
Alexey F. Topunov
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Oxidative Modification ◽  
Dependent Manner ◽  
Heme Group ◽  
Tyrosine Residues ◽  
Carbonyl Derivatives ◽  
Dinitrosyl Iron ◽  
Dose Dependent ◽  
Covalent Crosslinks

Dinitrosyl iron complexes (DNICs) are a physiological form of nitric oxide (•NO) in an organism. They are able not only to deposit and transport •NO, but are also to act as antioxidant and antiradical agents. However, the mechanics of hemoglobin-bound DNICs (Hb-DNICs) protecting Hb against peroxynitrite-caused, mediated oxidative modification have not yet been scrutinized. Through EPR spectroscopy we show that Hb-DNICs are destroyed under the peroxynitrite action in a dose-dependent manner. At the same time, DNICs inhibit the oxidation of tryptophan and tyrosine residues and formation of carbonyl derivatives. They also prevent the formation of covalent crosslinks between Hb subunits and degradation of a heme group. These effects can arise from the oxoferryl heme form being reduced, and they can be connected with the ability of DNICs to directly intercept peroxynitrite and free radicals, which emerge due to its homolysis. These data show that DNICs may ensure protection from myocardial ischemia.

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes of Human Fibroblasts

2018 ◽  
Vol 483 (4) ◽  
pp. 452-456
Author(s):  
A. Gizatullin ◽  
◽  
N. Akent'eva ◽  
N. Sanina ◽  
N. Shmatko ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Metabolic Processes ◽  
No Donors ◽  
Dinitrosyl Iron

The Influence of the Nature of the Ligand on the Antitumor Activity and Cytotoxic Effect of Binuclear Dinitrosyl Iron Complexes

BIOPHYSICS ◽  
2020 ◽  
Vol 65 (5) ◽  
pp. 863-868
Author(s):  
A. F. Vanin ◽  
L. A. Ostrovskaya ◽  
D. B. Korman ◽  
E. I. Nekrasova ◽  
O. O. Riabaya ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cytotoxic Effect ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Re-examination of the formation of dinitrosyl–iron complexes during reaction of S-nitrosothiols with Fe(II)

2001 ◽  
Vol 318 (1-2) ◽  
pp. 1-7 ◽  
Author(s):  
Simona Costanzo ◽  
Stephane Ménage ◽  
Roberto Purrello ◽  
Raffaele P Bonomo* ◽  
Marc Fontecave*
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Crucial role of lysosomal iron in the formation of dinitrosyl iron complexes in vivo

2006 ◽  
Vol 12 (3) ◽  
pp. 345-352 ◽  
Author(s):  
Hanna Lewandowska ◽  
Sylwia Męczyńska ◽  
Barbara Sochanowicz ◽  
Jarosław Sadło ◽  
Marcin Kruszewski
Keyword(s):  
Crucial Role ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Nitric Oxide ◽  
2019 ◽  
Vol 83 ◽  
pp. 24-32
Author(s):  
Anna B. Solovieva ◽  
Anatoly F. Vanin ◽  
Anatoly B. Shekhter ◽  
Nikolay N. Glagolev ◽  
Nadezhda A. Aksenova ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Wound Treatment ◽  
Dinitrosyl Iron
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