The effects of discontinuous morphine intoxication on the pools of neuroactive amino acids and biogenic amines in brain regions

2015 ◽  
Vol 9 (3) ◽  
pp. 221-226
Author(s):  
V. V. Lelevich ◽  
A. G. Vinitskaya ◽  
S. V. Lelevich ◽  
Yu. V. Sarana ◽  
E. M. Doroshenko
Keyword(s):  
Amino Acids ◽  
Biogenic Amines ◽  
Brain Regions ◽  
Neuroactive Amino Acids

scholarly journals THE EFFECT OF SINGLE COMPLEX INTOXICATION WITH MORPHINE AND ALCOHOL ON THE CONTENT OF NEUROACTIVE AMINO ACIDS IN THE BRAIN OF RATS

2020 ◽  
Vol 18 (5) ◽  
pp. 590-596
Author(s):  
I. M. Velichko ◽  
◽  
S. V. Lelevich ◽  
V. V. Lelevich ◽  
◽  
...  
Keyword(s):  
Amino Acids ◽  
Cerebral Cortex ◽  
Alcohol Intoxication ◽  
Adult Population ◽  
Brain Regions ◽  
Hplc Method ◽  
Male Rats ◽  
Neuroactive Amino Acids ◽  
Excitation Processes ◽  
The Brain

Background. Cases of combined consumption of surfactants (alcohol and opiates) in both the adult population and adolescents are quite common at present. An important role in the functional activity of the central nervous system is played by neuroactive amino acids, the level of which changes under the influence of psychotropic substances.Purpose. To study the content of neuroactive amino acids in the cerebral cortex, striatum, hypothalamus, midbrain and cerebellum in acute alcohol and morphine intoxication, as well as the complex administration of these substances.Material and methods. The experiments were carried out on white outbred male rats. Using the HPLC method in different parts of the brain, the levels of neurogenic amino acids were determined in acute alcohol and morphine intoxication, as well as their complex administration in different sections.Results. Acute complex morphine-alcohol intoxication is accompanied by manifestation of excitation processes in the striatum and hypothalamus, as well as inhibition in the midbrain. Alcohol-morphine intoxication leads to an increase in the content of GABA in all brain regions studied except the hypothalamus.Conclusion. Morphine-alcohol intoxication is accompanied by a decrease in the glycine content in the striatum, as well as an increase in its concentration in the midbrain and the level of glutamate in the hypothalamus. Alcohol-morphine intoxication leads to an increase in GABA levels in the cerebral cortex, striatum, midbrain and cerebellum.

Differential changes of neuroactive amino acids in samples obtained from discrete rat brain regions after systemic administration of saxitoxin

2009 ◽  
Vol 54 (5-6) ◽  
pp. 308-313 ◽  
Author(s):  
Rosa Carmina Cervantes Cianca ◽  
Rafael Durán Barbosa ◽  
Lilian Rosana Ferreira Faro ◽  
Lucia Vidal Adan ◽  
Ana Gago-Martínez ◽  
...  
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Brain Regions ◽  
Systemic Administration ◽  
Rat Brain Regions ◽  
Neuroactive Amino Acids

scholarly journals Metabolomic-Based Comparison of Traditional and Industrial Doenjang Samples with Antioxidative Activities

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1377
Author(s):  
Song-Hui Soung ◽  
Sunmin Lee ◽  
Seung-Hwa Lee ◽  
Hae-Jin Kim ◽  
Na-Rae Lee ◽  
...  
Keyword(s):  
Amino Acids ◽  
Statistical Analysis ◽  
Organic Acids ◽  
Biogenic Amines ◽  
Multivariate Statistical Analysis ◽  
Metabolite Profiling ◽  
New Products ◽  
Multivariate Statistical ◽  
Fermentation Processes

Numerous varieties of doenjang are manufactured by many food companies using different ingredients and fermentation processes, and thus, the qualities such as taste and flavor are very different. Therefore, in this study, we compared many products, specifically, 19 traditional doenjang (TD) and 17 industrial doenjang (ID). Subsequently, we performed non-targeted metabolite profiling, and multivariate statistical analysis to discover distinct metabolites in two types of doenjang. Amino acids, organic acids, isoflavone aglycones, non-DDMP (2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4- one) soyasaponins, hydroxyisoflavones, and biogenic amines were relatively abundant in TD. On the contrary, contents of dipeptides, lysophospholipids, isoflavone glucosides and DDMP-conjugated soyasaponin, precursors of the above-mentioned metabolites, were comparatively higher in ID. We also observed relatively higher antioxidant, protease, and β-glucosidase activities in TD. Our results may provide valuable information on doenjang to consumers and manufacturers, which can be used while selecting and developing new products.

scholarly journals A validated UPLC-MS/MS assay for the quantification of amino acids and biogenic amines in rat urine

2019 ◽  
Vol 1106-1107 ◽  
pp. 50-57 ◽  
Author(s):  
Nicola Gray ◽  
Robert S. Plumb ◽  
Ian D. Wilson ◽  
Jeremy K. Nicholson
Keyword(s):  
Amino Acids ◽  
Biogenic Amines ◽  
Rat Urine
Sign in / Sign up

Export Citation Format

Share Document