pH-Dependent Regulation of Electron and Proton Transport in Chloroplasts In Situ and In Silico

2020 ◽  
Vol 14 (2) ◽  
pp. 154-165 ◽  
Author(s):  
A. V. Vershubskii ◽  
A. N. Tikhonov
Keyword(s):  
In Silico ◽  
Proton Transport ◽  
Electron And Proton Transport ◽  
Ph Dependent

Functional and topological aspects of pH-dependent regulation of electron and proton transport in chloroplasts in silico

Biosystems ◽  
2011 ◽  
Vol 103 (2) ◽  
pp. 164-179 ◽  
Author(s):  
Alexey V. Vershubskii ◽  
Ilya V. Kuvykin ◽  
Vladimir I. Priklonskii ◽  
Alexander N. Tikhonov
Keyword(s):  
In Silico ◽  
Proton Transport ◽  
Electron And Proton Transport ◽  
Ph Dependent

scholarly journals In Silico Hemostasis Modeling and Prediction

2020 ◽  
Vol 40 (04) ◽  
pp. 524-535
Author(s):  
Dmitry Y. Nechipurenko ◽  
Aleksey M. Shibeko ◽  
Anastasia N. Sveshnikova ◽  
Mikhail A. Panteleev
Keyword(s):  
In Silico ◽  
Physiological Response ◽  
Platelet Adhesion ◽  
State Of The Art ◽  
Thrombus Formation ◽  
The State ◽  
Modeling And Prediction ◽  
Hemostatic System ◽  
Single Enzyme

AbstractComputational physiology, i.e., reproduction of physiological (and, by extension, pathophysiological) processes in silico, could be considered one of the major goals in computational biology. One might use computers to simulate molecular interactions, enzyme kinetics, gene expression, or whole networks of biochemical reactions, but it is (patho)physiological meaning that is usually the meaningful goal of the research even when a single enzyme is its subject. Although exponential rise in the use of computational and mathematical models in the field of hemostasis and thrombosis began in the 1980s (first for blood coagulation, then for platelet adhesion, and finally for platelet signal transduction), the majority of their successful applications are still focused on simulating the elements of the hemostatic system rather than the total (patho)physiological response in situ. Here we discuss the state of the art, the state of the progress toward the efficient “virtual thrombus formation,” and what one can already get from the existing models.

In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics

2014 ◽  
Vol 73 ◽  
pp. 250-257 ◽  
Author(s):  
Verónica Carrasco-Sánchez ◽  
Ariela Vergara-Jaque ◽  
Matías Zuñiga ◽  
Jeffrey Comer ◽  
Amalraj John ◽  
...  
Keyword(s):  
In Silico

scholarly journals A novel theranostic activity-based probe targeting kallikrein 7 for diagnosis and treatment of skin diseases

2021 ◽  
Author(s):  
Evangelos Bisyris ◽  
Eleni Zingkou ◽  
Golfo G Kordopati ◽  
Minos-Timotheos Matsoukas ◽  
Plato A. Magriotis ◽  
...  
Keyword(s):  
In Silico ◽  
Skin Diseases ◽  
Diagnosis And Treatment ◽  
Protease Substrate

We applied a new in silico approach for fishing protease-substrate motifs to design a kallirein 7 (KLK7)-specific phosphonate activity-based probe (ABP) to quantify the active KLK7 in situ. Epidermal application...

A mathematical model of electron and proton transport in oxygenic photosynthetic systems

2007 ◽  
Vol 77 (11) ◽  
pp. 2027-2039 ◽  
Author(s):  
A. V. Vershubskii ◽  
V. I. Priklonskii ◽  
A. N. Tikhonov
Keyword(s):  
Mathematical Model ◽  
Proton Transport ◽  
Electron And Proton Transport

scholarly journals Utilisation of 2,2DCP by Staphyloccocus aureus ZT and In Silico Analysis of Putative Dehalogenase

2021 ◽  
Vol 13 (1) ◽  
pp. 1-8
Author(s):  
Zatty Zawani Zaidi ◽  
Fahrul Huyop
Keyword(s):  
In Silico ◽  
Culture Media ◽  
Enrichment Culture ◽  
In Silico Analysis ◽  
In Situ Bioremediation ◽  
Isolation And Characterization ◽  
Halogenated Compound ◽  
Silico Analysis ◽  
Dehalogenase Gene

Halogenated compound such as 2,2-dichloropropionic acid is known for its toxicity and polluted many areas especially with agricultural activities. This study focused on the isolation and characterization of the bacterium that can utilise 2,2-dichloropropionic acid from palm oil plantation in Lenga, Johor and in silico analysis of putative dehalogenase obtained from NCBI database of the same genus and species. The bacterium was isolated using an enrichment culture media supplemented with 20 mM 2,2-dicholoropropionic acid as a carbon source.  The cells were grown at 30˚C with cells doubling time of 2.00±0.005 hours with the maximum growth at A680nm of 1.047 overnight. The partial biochemical tests and morphological examination concluded that the bacterium belongs to the genus Staphylococcus sp.. This is the first reported studies of  Staphylococcus sp. with the ability to grow on 2,2-dichloropropionic acid. The genomic DNA from NCBI database of the same species was analysed assuming the same genus and has identical genomic sequence.  The full genome of Staphylococcus sp. was screened for dehalogenase gene and  haloacid dehalogenase gene was detected in the mobile genetic element of the species revealed that the dehalogenase sequence has little identities to the previously reported dehalogenases.The main outcome of the studies suggesting an in situ bioremediation can be regarded as a natural process to detoxify the contaminated sites provided that the microorganisms contained a specialised gene sequence within its genome that served the nature for many long years. Whether microorganisms will be successful in destroying man-made contaminants entirely rely on what types of organisms play a role in in situ bioremediation and which contaminants are most susceptible to bioremediation. 

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