Application of Copper Salts To Initiate Cluster Formation of Organic Compounds by “Soft” Ionization Methods

Over the last 20 years, biological MS has changed out of all recognition. This is primarily due to the development in the 1980s of ‘soft ionization’ methods that permit the ionization and vaporization of large, polar, and thermally labile biomolecules. These developments in ionization mode have driven the design and manufacture of smaller and cheaper mass analysers, making the mass spectrometer a routine instrument in the biochemistry laboratory today. In the present review the revolutionary ‘soft ionization’ methods will be discussed with particular reference to electrospray. The mass analysis of ions will be described, and the concept of tandem MS introduced. Where appropriate, examples of the application of MS in biochemistry will be provided. Although the present review will concentrate on the MS of peptides/proteins and lipids, all classes of biomolecules can be analysed, and much excellent work has been done in the fields of carbohydrate and nucleic acid biochemistry.

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ChemInform Abstract: Field Desorption Mass Spectrometry of Natural Products. Part 16. Soft Ionization of Biomolecules: A Comparison of Ten Ionization Methods for Corrins and Vitamin B12

ChemInform ◽

10.1002/chin.198727367 ◽

1987 ◽

Vol 18 (27) ◽

Author(s):

H. M. SCHIEBEL ◽

H. R. SCHULTEN

Keyword(s):

Mass Spectrometry ◽

Natural Products ◽

Vitamin B12 ◽

Field Desorption ◽

Desorption Mass Spectrometry ◽

Soft Ionization ◽

Field Desorption Mass Spectrometry ◽

Ionization Methods

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Development of soft ionization using direct current pulse glow discharge plasma source in mass spectrometry for volatile organic compounds analysis

Spectrochimica Acta Part B Atomic Spectroscopy ◽

10.1016/j.sab.2017.11.002 ◽

2018 ◽

Vol 139 ◽

pp. 44-49 ◽

Cited By ~ 5

Author(s):

Yoko Nunome ◽

Kenji Kodama ◽

Yasuaki Ueki ◽

Ryo Yoshiie ◽

Ichiro Naruse ◽

...

Keyword(s):

Mass Spectrometry ◽

Glow Discharge ◽

Organic Compounds ◽

Direct Current ◽

Discharge Plasma ◽

Plasma Source ◽

Glow Discharge Plasma ◽

Soft Ionization ◽

Volatile Organic ◽

Pulse Glow Discharge

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Use of Electroless Plating Copper Thin Films for Catalysis

Materials Science Forum ◽

10.4028/www.scientific.net/msf.514-516.1328 ◽

2006 ◽

Vol 514-516 ◽

pp. 1328-1332 ◽

Cited By ~ 4

Author(s):

Alexsander T. Carvalho ◽

António Pereira Nascimento Filho ◽

Lilian Marques Silva ◽

Maria Lucia Pereira Silva ◽

Joana Catarina Madaleno ◽

...

Keyword(s):

Thin Films ◽

Copper Oxide ◽

Organic Compounds ◽

Cluster Formation ◽

Sample Pretreatment ◽

Polar Compounds ◽

Copper Films ◽

Raman Analysis ◽

All Solutions ◽

Oxide Bands

Recently, it was demonstrated that copper thin films show good adsorption characteristics for organic polar and non-polar compounds. Also, these films when used in small cavities can favor preconcentration of these organic compounds. It is also known that copper oxide can provide catalysis of organic compounds. Therefore, the aim of this work is the study of copper thin film catalysis when used in small cavities. Copper thin films, 25 nm thick, were deposited on silicon and/or rough silicon. These films do not show oxide on the surface when analyzed by Rutherford backscattering. Also, Raman analysis of these films showed only silicon bands, due to the substrate, however infrared spectroscopy shows oxide bands for films exposed to organic compound aqueous solutions. Cavities with copper films deposited inside were tested with a continuous flow of n-hexane, acetone or 2-propanol admitted in the system. The effluent was analyzed by Quartz Crystal Microbalance. It was shown that n-hexane or acetone can be trapped. The system also shows good reproducibility. Tests of catalysis were carried out using Raman spectroscopy and heating the films up to 300°C during 3 minutes after exposure to n-hexane, 2- propanol and acetophenone – pure or saturated aqueous solution. After the exposure, Raman spectra present intense bands only for 2-propanol, indicating that adsorption easily occurs. However, after heating with all solutions it was not found only silicon bands. Raman microscopy after heating also showed copper oxide cluster formation and, eventually, graphite formation. Although the heating provides oxide copper formation, this reaction does not produce a high amount of residues, which means that catalysis is possible in this condition. Thus, a simple device using copper thin films can be useful as sample pretreatment on microTAS development.

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