THE VALUE OF CYTOKERATIN 19 AND HUMAN PAPILLOMA VIRUS DNA AS MICROMETASTASIS MARKERS IN CERVICAL CANCER PATIENTS WITH INTERMEDIATE RISK FACTORS: IGCS-0022 Cervical Cancer

2015 ◽  
Vol 25 (Supp 1) ◽  
pp. 10-10
Author(s):  
Dae H. Gy ◽  
M. J. Kim ◽  
Y. H. Lee ◽  
G. O. Chong ◽  
Y. S. Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Cancer Patients ◽  
Cytokeratin 19 ◽  
Intermediate Risk ◽  
Papilloma Virus

scholarly journals Human Papilloma Virus and Other Risk Factors of Carcinoma Cervix

1970 ◽  
Vol 38 (1) ◽  
pp. 18-23 ◽  
Author(s):  
S Khatun ◽  
Syed Md Akram Hussain ◽  
F Hossain ◽  
A Choudhury
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Screening ◽  
Human Papilloma Virus ◽  
Sexual Activity ◽  
Hpv Infection ◽  
Carcinoma Cervix ◽  
Papilloma Virus ◽  
Hpv Dna ◽  
Screening Strategies

Cervical cancer is the most common cancer among women in many developing countries constituting 20%-30% of female cancers. The etiological factors of cervical cancer include environmental, social, sexual and sexually transmitted agents including human papilloma virus (HPV). HPV has identified in 99.7% invasive cancer. Objective of the study was to find out the prevalence of HPV-DNA virus among diagnosed cases of preinvasive and invasive diseases and to find out different sociodemographic parameters related to carcinoma cervix. This was a cross sectional study. The study has conducted in the department of Obstetrics and Gynaecology of Bangabandhu Sheikh Mujib Medical University. Duration of study was from May 2005 to May 2006. Samples were collected from diagnosed cases of CIN I, II, III and CIS and invasive cancer. Thirty cases were recruited for collection of cervical scraping. Sample were collected of in a specially designed sampler containing liquid transport medium and preserved in minus 20 Degree Celsius and sent to the DNA laboratory for processing and identification of HPV by hybrid capture II method. The results were analyzed by using SPSS version 11.0 and shown in tables and diagrams. The risk factors for HPV infection identified from the result. These are early sexual activity, years of sexual activity, urban people, and higher number of pregnancies. The test could identify HPV-DNA in 100 % of invasive and 50 % of preinvasive cancer. In this study HPV infection was found as a strong determinant for the development of cervical carcinoma and its precursors. Poor socio-economic condition, lower level of education, early marriage and first delivery, multi-parity, years of sexual activity are the risk factors for developing HPV infection. New guidelines for cervical cancer screening strategies could be able to develop from the information obtained from this study. A population-based study with larger sample will be required for the evaluation of cervical cancer screening strategies. Key words: HPV, Carcinoma Cervix   DOI: 10.3329/bmj.v38i1.3582 Bangladesh Medical Journal 38(1) 2009 18-23

Post-operative small pelvic intensity-modulated radiation therapy for early-stage cervical cancer with intermediate-risk factors: efficacy and toxicity

2021 ◽  
Author(s):  
Guangyu Zhang ◽  
Fangfang He ◽  
Li Miao ◽  
Haijian Wu ◽  
Youzhong Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Patients ◽  
Early Stage ◽  
Intensity Modulated Radiotherapy ◽  
Disease Free Survival ◽  
Intermediate Risk ◽  
Intensity Modulated ◽  
Early Stage Cervical Cancer

Abstract Objective The aim of the present study was to retrospectively evaluate the toxicity and efficacy of post-operative small pelvic intensity-modulated radiotherapy in early-stage cervical cancer patients with intermediate-risk factors. Methods Between 2012 and 2016, 151 patients who had cervical cancer (International Federation of Gynecology and Obstetrics stage I–IIA) with intermediate-risk factors were treated with post-operative small pelvic intensity-modulated radiotherapy. The median dose of 50.4 Gy in 28 fractions with small pelvic intensity-modulated radiotherapy was prescribed to the planning target volume. The intensity-modulated radiotherapy technique used was conventional fixed-field intensity-modulated radiotherapy or helical tomotherapy. Results The median follow-up was 37 months. The 3-year disease-free survival and overall survival rates were 89 and 96%, respectively. A total of 144 patients (95.3%) were alive at the last follow-up. In total, 6 patients (3.9%) had recurrence: locoregional recurrence in 3 patients (2%), distant metastasis in 2 (1.3%), and both in 1 (0.6%). Diarrhoea was the most common acute toxicity. There were no patients suffering from acute or late grade ≥ 3 toxicity. Only 4 patients (2.6%) had late grade 2 toxicities. Conclusions For early-stage cervical cancer patients with intermediate-risk factors, post-operative small pelvic intensity-modulated radiotherapy was safe and well tolerated. The rates of acute and late toxicities were quite satisfactory.

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