scholarly journals Assessment of neutrophil chemotaxis and random migration in childhood. Comparison between leading-front and lower surface count methods.

1980 ◽  
Vol 55 (4) ◽  
pp. 296-298 ◽  
Author(s):  
S Al-Nakeeb ◽  
E N Thompson
Keyword(s):  
Lower Surface ◽  
Neutrophil Chemotaxis ◽  
Random Migration

Neutrophil chemotaxis, random migration, and adherence in patients with hyperthyroidism

1989 ◽  
Vol 121 (6) ◽  
pp. 817-820 ◽  
Author(s):  
B. Wolach ◽  
B. Lebanon ◽  
A. Jedeikin ◽  
M. S. Shapiro ◽  
L. Shenkman
Keyword(s):  
Thyroid Function ◽  
Chemotactic Activity ◽  
Neutrophil Chemotaxis ◽  
Phagocytic Cells ◽  
Random Migration ◽  
Significant Difference ◽  
Neutrophil Adherence ◽  
Hyperthyroid Patients ◽  
Normal Controls ◽  
Neutrophil Chemotactic Activity

Abstract. We have examined neutrophil adherence, chemotactic activity, and random migration in 35 hyperthyroid patients with Graves' disease and 106 normal volunteers. No statistically significant differences were found between granulocyte adherence of 17 hyperthyroid subjects (67 ± 15.6%) and 81 healthy volunteers (63.1 ± 17%). In 3 thyrotoxic patients, impaired neutrophil adherence was found, which resolved when thyroid function returned to normal. The neutrophil chemotactic activity of 32 normal controls was 107.5 ± 21.4 cells, and the random migration 36 ± 15.5 cells. No statistically significant difference was demonstrated in 13 hyperthyroid patients who had a neutrophil chemotactic activity of 102 ± 14.6 cells and a random migration of 31.2 ± 13.2 cells. Defective chemotactic activity and random migration was found in 2 patients. Neutrophil functions returned to normal in one of the two subjects who were re-evaluated when thyroid function recovered. In summary, 14% of hyperthyroid patients had impaired leukocyte functions. However, severe pyogenic infections are quite rare in hyperthyroid patients, indicating that the observed alterations in function of phagocytic cells are not clinically important.

NEUTROPHIL CHEMOTAXIS AND RANDOM MIGRATION IN PRETERM AND TERM INFANTS WITH SEPSIS

2000 ◽  
Vol Volume 17 (Number 02) ◽  
pp. 107-112 ◽  
Author(s):  
Münevver Türkmen ◽  
Mehmet Satar ◽  
Aytug Atici
Keyword(s):  
Neutrophil Chemotaxis ◽  
Term Infants ◽  
Random Migration

scholarly journals Filifactor alocis Promotes Neutrophil Degranulation and Chemotactic Activity

2016 ◽  
Vol 84 (12) ◽  
pp. 3423-3433 ◽  
Author(s):  
Cortney L. Armstrong ◽  
Irina Miralda ◽  
Adam C. Neff ◽  
Shifu Tian ◽  
Aruna Vashishta ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Periodontal Pocket ◽  
Human Neutrophils ◽  
Neutrophil Chemotaxis ◽  
Granule Exocytosis ◽  
Content Type ◽  
Innate Defense ◽  
Random Migration ◽  
Neutrophil Degranulation ◽  
Filifactor Alocis

Filifactor alocis is a recently recognized periodontal pathogen; however, little is known regarding its interactions with the immune system. As the first-responder phagocytic cells, neutrophils are recruited in large numbers to the periodontal pocket, where they play a crucial role in the innate defense of the periodontium. Thus, in order to colonize, successful periodontal pathogens must devise means to interfere with neutrophil chemotaxis and activation. In this study, we assessed major neutrophil functions, including degranulation and cell migration, associated with the p38 mitogen-activated protein kinase (MAPK) signaling pathway upon challenge with F. alocis. Under conditions lacking a chemotactic gradient, F. alocis -challenged neutrophils had increased migration compared to uninfected cells, indicating that F. alocis increases chemokinesis in human neutrophils. In addition, neutrophil chemotaxis induced by interleukin-8 was significantly enhanced when cells were challenged with F. alocis , compared to noninfected cells. Similar to live bacteria, heat-killed F. alocis induced both random and directed migration of human neutrophils. The interaction of F. alocis with Toll-like receptor 2 induced granule exocytosis along with a transient ERK1/2 and sustained p38 MAPK activation. Moreover, F. alocis -induced secretory vesicle and specific granule exocytosis were p38 MAPK dependent. Blocking neutrophil degranulation with TAT-SNAP23 fusion protein significantly reduced the chemotactic and random migration induced by F. alocis . Therefore, we propose that induction of random migration by F. alocis will prolong neutrophil traffic time in the gingival tissue, and subsequent degranulation will contribute to tissue damage.

Defects of Neutrophil Chemotaxis and Random Migration in Thalassemia Major

PEDIATRICS ◽  
1977 ◽  
Vol 60 (3) ◽  
pp. 349-351
Author(s):  
Abdul J. Khan ◽  
Chuck-Kwan Lee ◽  
James A. Wolff ◽  
Hsin Chang ◽  
Parvin Khan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Liver Disease ◽  
Polymorphonuclear Leukocytes ◽  
Thalassemia Major ◽  
Neutrophil Chemotaxis ◽  
Primary Defect ◽  
Random Migration

Chemotactic and random migrations in a group of 11 patients with thalassemia major were found to be defective. This may be partially the basis for the predilection to infection occasionally observed in these patients. These findings may reflect a primary defect of polymorphonuclear leukocytes or may be secondary to associated liver disease and/or diabetes mellitus. Further studies are required to define the mechanisms involved.

scholarly journals Inhibiting Effects of Human Plasma and Serum on Neutrophil Random Migration and Chemotaxis

Blood ◽  
1974 ◽  
Vol 44 (6) ◽  
pp. 843-848 ◽  
Author(s):  
H. U. Keller ◽  
M. W. Hess ◽  
H. Cottier
Keyword(s):  
Neutrophil Granulocytes ◽  
Neutrophil Chemotaxis ◽  
Chemotactic Migration ◽  
Experimental Conditions ◽  
Random Migration ◽  
The Past ◽  
Nitroblue Tetrazolium Reduction ◽  
Normal Human ◽  
Tetrazolium Reduction ◽  
Increased Susceptibility

Abstract Various authors have associated increased susceptibility to infectious diseases in certain patients to inhibitors of neutrophil chemotaxis demonstrable in serum or diluted plasma of these patients. The present experiments showed, however, that serum and diluted plasma but not undiluted plasma from normal human donors consistently inhibited chemotactic migration of autologous human neutrophil granulocytes. Therefore, the presence of such inhibitors in the circulating blood can only be assessed by the evaluation of undiluted plasma. The findings suggest that the experimental conditions which have been used in the past to demonstrate such inhibitors in the circulating blood of patients with increased susceptibility to infections are inadequate, and results need reexamination. The inhibitors affect random locomotion and chemotaxis of neutrophil granulocytes but not phagocytosis or the metabolic burst resulting in nitroblue—tetrazolium reduction. On the other hand, phagocytosis of Staphylococcus albus rendered neutrophils chemotactically unresponsive. The significance of so-called cellular defects of neutrophil chemotaxis in such patients is also considered.

Reversible Defect of Neutrophil Chemotaxis and Random Migration in Primary Hyperparathyroidism

1979 ◽  
Vol 48 (4) ◽  
pp. 582-584 ◽  
Author(s):  
FARIDA KHAN ◽  
ABDUL J. KHAN ◽  
C. PAPAGAROUFALIS ◽  
JACOB WARMAN ◽  
PARVIN KHAN ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Neutrophil Chemotaxis ◽  
Random Migration ◽  
Reversible Defect

Assessment of Neutrophil Chemotaxis and Random Migration in Children with Thalassemia Major

1996 ◽  
Vol 13 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Necil Kutukculer ◽  
Onur Kutlu ◽  
Gungor Nisli ◽  
Senay Oztop ◽  
Nazan Cetingul ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Neutrophil Chemotaxis ◽  
Random Migration

Assessment of Neutrophil Chemotaxis and Random Migration in Children and Adults

1985 ◽  
Vol 76 (2) ◽  
pp. 116-119 ◽  
Author(s):  
P.J. Hindocha ◽  
S.B. Hedges ◽  
C.B.S. Wood
Keyword(s):  
Neutrophil Chemotaxis ◽  
Random Migration

Depressed Neutrophil Chemotaxis in Infants with Cow's Milk and/or Soy Protein Intolerance

PEDIATRICS ◽  
1981 ◽  
Vol 67 (2) ◽  
pp. 264-268
Author(s):  
Helen L. Butler ◽  
William J. Byrne ◽  
Daniel J. Marmer ◽  
Arthur R. Euler ◽  
Russell W. Steele
Keyword(s):  
Soy Protein ◽  
Matched Control ◽  
Cow’S Milk ◽  
Neutrophil Chemotaxis ◽  
Cow's Milk ◽  
Random Migration ◽  
Clinical Recovery ◽  
Control Subjects ◽  
Protein Intolerance

Neutrophil chemotaxis and random migration were studied in 11 infants with active cow's milk and/or soy protein intolerance and in an additional four infants following clinical recovery. Results were compared to 15 age-matched control subjects. Infants with active intolerance exhibited depressed chemotaxis and enhanced random migration. The four recovered infants had values similar to those of control subjects.

Sign in / Sign up

Export Citation Format

Share Document