AB1287 Indocyanine green enhanced fluorescence optical imaging as a tool for quantifying the joint inflammation in collagen induced arthritis

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 711.7-711
Author(s):  
M.I. Kang ◽  
K.H. Park ◽  
Y. Kang ◽  
S.W. Lee ◽  
S.K. Lee ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Optical Imaging ◽  
Joint Inflammation ◽  
Enhanced Fluorescence ◽  
Collagen Induced Arthritis ◽  
Fluorescence Optical Imaging

scholarly journals Fluorescence optical imaging: ready for prime time?

RMD Open ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e001497
Author(s):  
Sarah Ohrndorf ◽  
Anne-Marie Glimm ◽  
Mads Ammitzbøll-Danielsen ◽  
Mikkel Ostergaard ◽  
Gerd R Burmester
Keyword(s):  
Optical Imaging ◽  
Power Doppler ◽  
Joint Inflammation ◽  
Diagnostic Process ◽  
The Novel ◽  
The European Union ◽  
Fluorescence Optical Imaging ◽  
Disturbed Microcirculation ◽  
The Usa ◽  
Magnetic Resonance Imaging Mri

The novel technique of fluorescence optical imaging (FOI, Xiralite), which is approved in the European Union and the USA for clinical use, has been the object of studies since 2009. Indocyanine green-based FOI can demonstrate an impaired microcirculation caused by inflammation in both hands in one examination. Several studies have investigated FOI for detection of joint inflammation by comparing FOI to magnetic resonance imaging (MRI) and/or musculoskeletal ultrasound (MSUS). The results have shown a generally good agreement (>80%) between FOI and clinical examination, MRI and MSUS by power Doppler in inflammatory joint diseases. Moreover, characteristic enhancements in skin and nails are seen in PsA, which potentially can be useful in the diagnostic process of early undifferentiated arthritis. Furthermore, FOI has been investigated for the visualisation of a disturbed microcirculation in the hands and fingers of patients with systemic sclerosis (SSc), highlighting the potential of monitoring vascular changes in SSc and other vasculopathies. The available data indicate that it is time to consider FOI as a useful part of the imaging repertoire in rheumatology clinical practice, particularly where MSUS and MRI are not easily available.

SAT0416 Interreader-reliability of standardized evaluation of ICG-enhanced fluorescence-optical imaging:

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 613.1-613
Author(s):  
S.G. Werner ◽  
U. Käßer ◽  
C. Amberger ◽  
M. Piesga ◽  
F. Spiecker ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Enhanced Fluorescence ◽  
Fluorescence Optical Imaging

scholarly journals Analysis of distribution and severity of inflammation in patients with osteoarthitis compared to rheumatoid arthritis by ICG-enhanced fluorescence optical imaging and musculoskeletal ultrasound: a pilot study

2015 ◽  
Vol 75 (3) ◽  
pp. 566-570 ◽  
Author(s):  
A-M Glimm ◽  
S G Werner ◽  
G R Burmester ◽  
M Backhaus ◽  
S Ohrndorf
Keyword(s):  
Rheumatoid Arthritis ◽  
Optical Imaging ◽  
Joint Inflammation ◽  
Musculoskeletal Ultrasound ◽  
Imaging Method ◽  
Hand Osteoarthritis ◽  
Dominant Hand ◽  
Fluorescence Optical Imaging ◽  
Inflammatory Status ◽  
Inflammatory Changes

BackgroundIn rheumatoid arthritis (RA), hand synovitis appears especially in wrist, metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. In hand osteoarthritis (OA), potential inflammatory changes are mainly present in PIP and distal interphalangeal (DIP) joints. Joint inflammation can be visualised by fluorescence optical imaging (FOI) and musculoskeletal ultrasound (US).ObjectiveComparison of the amount and distribution of inflammatory signs in wrist and finger joints of the clinically dominant hand in patients with OA and RA by FOI and gray-scale (GSUS) and power Doppler US (PDUS).MethodsFOI and GSUS/PDUS were performed in 1.170 joints (wrists, MCP, PIP, DIP) in 90 patients (67 RA, 23 OA). Joint inflammation was graded by a semiquantitative score (0–3) for each imaging method.ResultsGSUS/PDUS showed wrist and MCP joints mostly affected in RA. DIP joints were graded higher in OA. In FOI, RA and OA featured inflammatory changes in the respective joint groups depending on the phase of fluorescence dye flooding.ConclusionsUS and FOI detected inflammation in both RA and OA highlighting the inflammatory component in the course of OA. The different inflammatory patterns and various shapes of fluorescence enhancement in FOI may offer opportunities to distinguish and determine the inflammatory status in both diseases.

SAT0526 ICG-Enhanced Fluorescence Optical Imaging (FOI) Detects Typical Inflammatory Changes in Subjects with Arthralgia and Psoriasis

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A759.3-A760 ◽  
Author(s):  
S. G. Werner ◽  
F. Spiecker ◽  
S. Mettler ◽  
G. Lind-Albrecht ◽  
O. Wiemann ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Enhanced Fluorescence ◽  
Fluorescence Optical Imaging ◽  
Inflammatory Changes
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