FRI0412 The effects of golimumab on the progression of subclinical atherosclerosis and arterial stiffness in patients with ankylosing spondylitis – a randomized, placebo- controlled trial

Objective.Preliminary evidence suggests that ankylosing spondylitis (AS) is associated with an increased cardiovascular (CV) risk. We investigated subclinical atherosclerosis and arterial stiffness in patients with AS compared with controls, and identified CV and AS related risk factors for atherosclerotic disease.Methods.A total of 59 patients with AS who were scheduled for etanercept treatment according to the ASsessments in Ankylosing Spondylitis guidelines and 30 healthy controls were recruited. Subclinical atherosclerosis was assessed as the average intima-media thickness (IMT) of the common carotid artery. Arterial stiffness was determined by distensibility, compliance, and Young’s elastic modulus of the carotid artery.Results.AS patients had a greater IMT (0.62 ± 0.09 mm vs 0.57 ± 0.09 mm in controls; p = 0.02), a difference that remained after adjustment for traditional CV risk factors. AS was associated with higher carotid pulse pressure (47 ± 7 mm Hg vs 44 ± 8 mm Hg in controls; p = 0.04), but this was not due to local vessel wall properties. Among AS patients, age and body mass index (BMI) were determinants of IMT. Age, BMI, total cholesterol, triglycerides, and disease duration were identified as determinants of stiffness indices. No relationship was found between large-vessel properties and higher Bath AS disease indices or C-reactive protein values.Conclusion.AS was associated with subclinical atherosclerosis and arterial stiffness, supporting epidemiological evidence of an increased CV risk in these patients. Whether these differences are due to AS or to a higher prevalence of CV risk factors in patients with AS remains to be determined.

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Assessment of arterial stiffness and epicardial adipose tissue thickness in predicting the subclinical atherosclerosis in patients with ankylosing spondylitis

Clinical and Experimental Hypertension ◽

10.1080/10641963.2020.1833025 ◽

2020 ◽

Vol 43 (2) ◽

pp. 169-174

Author(s):

Kenan Demir ◽

Ahmet Avcı ◽

Serpil Ergulu Esmen ◽

Abdullah Tuncez ◽

Muhammed Ulvi Yalcın ◽

...

Keyword(s):

Adipose Tissue ◽

Ankylosing Spondylitis ◽

Arterial Stiffness ◽

Epicardial Adipose Tissue ◽

Subclinical Atherosclerosis ◽

Tissue Thickness ◽

Epicardial Adipose Tissue Thickness

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FRI0455 High intensity aerobic exercise in ankylosing spondylitis reduces arterial stiffness: results from a randomized controlled trial

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-eular.1582 ◽

2013 ◽

Vol 72 (Suppl 3) ◽

pp. A529.1-A529

Author(s):

I. J. Berg ◽

A. G. Semb ◽

S. Halvorsen ◽

C. Fongen ◽

H. Dagfinrud ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Ankylosing Spondylitis ◽

Arterial Stiffness ◽

Aerobic Exercise ◽

High Intensity ◽

Controlled Trial ◽

Randomized Controlled

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Effect of Acupuncture on Artery Elasticity for Atherosclerosis: A Randomized Controlled Trial

10.21203/rs.3.rs-1120988/v1 ◽

2022 ◽

Author(s):

Wenbin Fu ◽

Lin Zhao ◽

Jian-xing Zhang ◽

Si-ting Ye ◽

Ling-cui Meng ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Controlled Trial ◽

Subclinical Atherosclerosis ◽

Sham Acupuncture ◽

Acupuncture Group ◽

Arterial Elasticity ◽

Secondary Outcomes

Abstract Background Atherosclerosis (AS) is a chronic arterial disease. Atherosclerosis related diseases, like myocardial infarctions (MI) and strokes have the highest mortality and disability rate. However, limited evidence verified the effects of acupuncture on arterial stiffness for subclinical atherosclerosis. We hypothesized that acupuncture could improve arterial stiffness in subclinical atherosclerosis and resist plaque progression. The aim of this study is to assess the effect of acupuncture on arterial elasticity via ultrafast pulse wave velocity (ufPWV) and explore the effect of acupuncture on lipid level and platelet function for subclinical atherosclerosis patients.MethodsThis was a randomized parallel controlled trial included 44 patients. Patients were assigned in a 1:1 ratio to acupuncture group and sham acupuncture group. Patients completed 24 treatments in total within 12 weeks of intervention. The primary outcome was ultrafast pulse wave velocity (ufPWV) assessed after every 4-weeks treatment; the secondary outcomes were carotid intima-media thickness (cIMT), blood lipid levels, fibrinogen (FIB) and blood platelet. Intention-to-treat (ITT) principle was applied and data sets were analyzed using SPSS 20.0 software.ResultsAmong the 44 randomly assigned patients, changes of right-side BS value in TA group (0.841) at week 12 were greater than SA group (-0.189), with a mean difference of 1.030 (95% CI, 0.320, 1.739; P=0.006). Similar results were observed in right-side ES, left-side BS, left-side ES at week 12. As to secondary outcomes, compared with SA group(1.08mm), the TA group(0.98mm) showed a significant decline in mean of left-side IMT at week 12. (Z= -2.118; P=0.034). There were no serious adverse events.ConclusionsAmong patients with Carotid intima-media thickening, both-side carotids arterial elasticity is significantly improved after 12-week acupuncture compared with sham acupuncture. The effects of acupuncture are more noticeable at week 12 during end-systole.Trial registrationThe trial was registered at http://www.chictr.org.cn (NO. ChiCTR1900025551, 31/08/2019)

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