Focusing on health services to patients (patient center care) is a new paradigm that prioritizes quality and safe services (safety) for patients by considering the needs and values of patients. Many patient demands are filed with hospitals due to insecurity of safety measures which are very much related to patient safety culture. In conclusion, based on the multiple linear regression equation, namely: patient safety culture = -5,968 + 0,283 communication + 0,212 work climate + 0,856 culture not looking for who is wrong + 0.524 incident reporting +0,364 education and training, then the variables that most influence on patient safety culture are culture is not looking for who is wrong. The researcher suggests that it is necessary to develop education and training on patient safety culture and instill a culture of not looking for who is wrong but why mistakes occur.