scholarly journals Anterior capsular defect with acute anterior subcapsular cataract in herpetic keratouveitis

2014 ◽  
Vol 2014 (sep16 1) ◽  
pp. bcr2014206056-bcr2014206056 ◽  
Author(s):  
T. Arora ◽  
N. Sharma ◽  
S. Arora ◽  
J. S. Titiyal
Keyword(s):  
Anterior Subcapsular Cataract ◽  
Capsular Defect

scholarly journals Modified technique of managing congenital cataract with pre-existing posterior capsular defect (PPCD)

2021 ◽  
Vol 14 (5) ◽  
pp. e243330
Author(s):  
Sudarshan Khokhar ◽  
Mousumi Banerjee ◽  
Sanketh Singh Rathod ◽  
Sushil Kumar
Keyword(s):  
Congenital Cataract ◽  
Modified Technique ◽  
Capsular Defect

Dorsal Capsular Defect and Synovial Fistula to the Fourth Extensor Compartment: A Late Complication after Arthroscopic Dorsal Wrist Ganglionectomy

2018 ◽  
Vol 23 (03) ◽  
pp. 404-407
Author(s):  
Ines C. Lin ◽  
Alexander Y. Shin ◽  
Allen T. Bishop
Keyword(s):  
Open Surgery ◽  
Ligament Reconstruction ◽  
Late Complication ◽  
Wrist Pain ◽  
Safe Procedure ◽  
Recurrence Rates ◽  
Arthroscopic Findings ◽  
Extensor Compartment ◽  
Capsular Defect

Arthroscopic dorsal wrist ganglionectomy is demonstrably a safe procedure with recurrence rates comparable to open surgery. We present a patient with wrist pain following arthroscopic ganglion excision. MRI and arthroscopic findings showed a large dorsal capsular defect, synovial fistula to the fourth extensor compartment, and dorsal radiocarpal ligament resection. Ligament reconstruction and capsular imbrication resolved her symptoms. We postulate that this complication resulted from a large capsular resection. Because we feel that it can be difficult to judge the size of the debridement through an arthroscope, the need for adequate capsular resection in dorsal wrist ganglionectomy needs to be balanced by consideration of potential complications from more aggressive capsular debridement, and thus we feel that capsular resection should be limited to no more than 1 cm2.

scholarly journals Long Noncoding RNA NEAT1 Regulates TGF-β2-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through the miR-34a/Snail1 and miR-204/Zeb1 Pathways

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Ning Dong
Keyword(s):  
Epithelial Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Rna Binding ◽  
Epithelial Mesenchymal Transition ◽  
Luciferase Assay ◽  
Lens Epithelial Cells ◽  
Dependent Manner ◽  
Mesenchymal Transition ◽  
Anterior Subcapsular Cataract

The aim of this study was to explore whether the long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1)/miR-34a/Snail1 and NEAT1/miR-204/Zeb1 pathways are involved in epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs). Primary human LECs (HLECs) were separated and cultured. Our results identified that TGF-β2 induces NEAT1 overexpression in a dose-dependent manner and a time-dependent manner. Additionally, TGF-β2 induced downregulation of E-cadherin and upregulation of fibronectin in primary HLECs through a NEAT1-dependent mechanism. Microarray analysis showed that NEAT1 overexpression inhibited the miR-34a and miR-204 levels in the LECs. The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). Mechanistic studies revealed that NEAT1 negatively regulates miR-34a or miR-204, and miR-34a or miR-204 directly targets Snail1 or Zeb1 by luciferase assay and RNA-binding protein immunoprecipitation assay, respectively. Overall, the NEAT1/miR-34a/Snail1 and NEAT1/miR-204/Zeb1 pathways are involved in TGF-β2-induced EMT of HLECs. In summary, TGF-β2 induces NEAT1 overexpression, which in turn suggests that NEAT1 acts as a ceRNA targeting Snail1 or Zeb1 by binding miR-34a or miR-204, and promotes the progression of EMT of LECs.

Pathogenesis of Fixed Dilated Pupil (Urrets-Zavalía Syndrome) after Deep Lamellar Keratoplasty in Keratoconus

2016 ◽  
Vol 5 (1) ◽  
pp. 32-34
Author(s):  
José RC Reis ◽  
Alberto Diniz-Filho ◽  
Fábio M Rocha
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Young Patients ◽  
Case Series ◽  
Early Postoperative Period ◽  
Lamellar Keratoplasty ◽  
Deep Anterior Lamellar Keratoplasty ◽  
Anterior Lamellar Keratoplasty ◽  
Deep Lamellar Keratoplasty ◽  
Anterior Subcapsular Cataract

ABSTRACT Purpose To present a case series of patients that developed Urrets-Zavalia syndrome (UZS) after deep anterior lamellar keratoplasty (DALK) for treating keratoconus and discuss the mechanisms for the syndrome. Materials and methods Retrospective chart analysis of patients who developed UZS after DALK at the Cornea Unit, Hospital São Geraldo, Federal University of Minas Gerais. Results We present a series of 3 patients with features consistent with UZS, after undergoing DALK. Elevated intraocular pressure (IOP) was noted in the early postoperative period in 2 cases, despite the fact that the other case reported eye pain, headache, and nausea at the night after the surgery with undocumented IOP. Although at different extents, the pupil remained atrophic and dilated in all 3 eyes, and 2 of them developed anterior subcapsular cataract. Conclusion Iris ischemia resulting from occlusion of iris root vessels due to elevated IOP higher than diastolic blood pressure causes UZS. Elevated IOP should be monitored, especially in young patients with low diastolic blood pressure, in order to avoid the occurrence of the syndrome. How to cite this article Reis JRC, Diniz-Filho A, Rocha FM, Torquetti L. Pathogenesis of Fixed Dilated Pupil (Urrets-Zavalía Syndrome) after Deep Lamellar Keratoplasty in Keratoconus. Int J Kerat Ect Cor Dis 2016;5(1):32-34.

scholarly journals Lens-Specific Expression of TGF-β Induces Anterior Subcapsular Cataract Formation in the Absence of Smad3

2006 ◽  
Vol 47 (8) ◽  
pp. 3450 ◽  
Author(s):  
Alice Banh ◽  
Paula A. Deschamps ◽  
Jack Gauldie ◽  
Paul A. Overbeek ◽  
Jacob G. Sivak ◽  
...  
Keyword(s):  
Cataract Formation ◽  
Specific Expression ◽  
Anterior Subcapsular Cataract

A Novel Technique for Soft-Tissue Defect Repair After Traumatic Rupture of the Extensor Hallucis Longus Tendon

2021 ◽  
Vol 111 (3) ◽  
Author(s):  
Ellianne Nasser ◽  
William Clark ◽  
Michael Gibboney
Keyword(s):  
Tendon Rupture ◽  
Metatarsophalangeal Joint ◽  
Soft Tissue Defect ◽  
Joint Capsule ◽  
Traumatic Rupture ◽  
First Metatarsophalangeal Joint ◽  
Novel Approach ◽  
Extensor Hallucis Longus ◽  
Physiologic Function ◽  
Capsular Defect

Background Surgical repair of extensor hallucis longus (EHL) tendon rupture with a concomitant capsular defect has not been reported in the literature. This case presents a novel approach to EHL tendon rupture repair along with repair of a first metatarsophalangeal joint capsule defect. Methods A case study is presented of a 61-year-old man with a traumatic EHL tendon rupture and capsular defect treated with an EHL tendon turndown flap and tenodesis to the extensor hallucis brevis and capsularis tendons with autograft flap reconstruction of the first metatarsophalangeal joint capsule. Discussion A 61-year-old man presented with an acute traumatic EHL tendon rupture and first metatarsophalangeal joint capsule compromise after a chainsaw injury. He subsequently lost dorsiflexion of his hallux, and magnetic resonance imaging confirmed a 2.2-cm gap in the EHL tendon. He was treated with an EHL tendon turndown flap and tenodesis to the extensor hallucis brevis and capsularis tendons to reestablish dorsiflexion to the hallux. The injury was noted to infiltrate the first metatarsophalangeal joint capsule and was treated with an autograft of the first metatarsophalangeal joint capsule for a capsular defect. At 1-year follow-up the patient has regained dorsiflexion of the hallux and is back to activities such as snow skiing without pain. Conclusions Ruptures of the EHL tendon with first metatarsophalangeal joint capsule defects have not been reported in the literature. Herein, a novel approach was used to reestablish physiologic function to the EHL tendon and provide sufficient coverage of the first metatarsophalangeal joint.

Preexisting Posterior Capsular Defect

2021 ◽  
pp. 107-114
Author(s):  
Chirakshi Dhull ◽  
Sudarshan Kumar Khokhar
Keyword(s):  
Capsular Defect

scholarly journals Anterior lens capsule rupture following minor blunt trauma with a past history of minimal change glomerulopathy

2014 ◽  
Vol 6 (2) ◽  
pp. 230-233
Author(s):  
Stephen V Lau V Lau ◽  
Prerana Kansakar ◽  
Ben Limbu
Keyword(s):  
Unusual Case ◽  
Past History ◽  
Lens Capsule ◽  
Minimal Change ◽  
Minor Trauma ◽  
Current Case ◽  
Anterior Lens Capsule ◽  
History Of ◽  
The Right ◽  
Anterior Subcapsular Cataract

Introduction: Few cases have been reported describing anterior lens capsule ruptures secondary to blunt trauma.Case: We present an unusual case of anterior lens capsule ruptures following minor trauma from a human elbow with a two-year history of minimal-change glomerulopathy in a 17-year-old male. In addition to having bilateral posterior subcapsular cataracts, he developed an anterior subcapsular cataract underlying the anterior lens rupture in the right eye. He was managed conservatively.  Observations: The current case differs from those of the existing literature in terms of the characteristics of the physical insult and the eye on presentation. We suggest there could be a predisposing anterior capsule weakness secondary to the minimal-change glomerulopathy or the associated drug therapy, but there needs to be more evidence to confirm or refute our claim.  Conclusions: Anterior lens capsule may rupture following minor trauma on a background of minimal-change glomerulopathy.DOI: http://dx.doi.org/10.3126/nepjoph.v6i2.11714Nepal J Ophthalmol 2014; 6 (12): 230-233 

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