Comprehensive molecular imaging of malignant transformation of giant cell tumour of bone reveals diverse disease biology

Malignant transformation of giant cell tumour of the bone is extremely rare. In addition, bone transformation in giant cell tumour may occur in different phases. With conventional X-rays, CT scans or MRIs, it may be challenging to distinguish among different phases of bone transformation, normal bone, soft tissue disease and bone disease (benign vs malignant lesions) and changes in multiple organs such as lung, liver and lymph nodes unless every lesion is biopsied, which is not practical. Molecular imaging with different isotopes (Tc-99m phosphonate, 2-deoxy-2-(18F)fluoro-d-glucose and sodium fluoride-18) may help to better characterise the disease. We hypothesised that molecular imaging could offer qualitative and quantitative characterisation of all stages of bone formation, destruction, reactivity or neoplasia in a patient with giant cell tumour of the bone, and we present the first case of molecular imaging where bone formation was seen in multiple soft tissues, such as lungs, muscles, lymph nodes and liver.

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CUBITAL TUNNEL SYNDROME DUE TO GIANT CELL TUMOUR OF TENDON SHEATHS

Hand Surgery ◽

10.1142/s0218810406003188 ◽

2006 ◽

Vol 11 (01n02) ◽

pp. 89-91 ◽

Cited By ~ 4

Author(s):

G. Mitsionis ◽

E. E. Pakos ◽

I. Gavriilidis ◽

Anna Batistatou

Keyword(s):

Giant Cell ◽

Giant Cell Tumour ◽

Present Report ◽

Cubital Tunnel Syndrome ◽

Cell Tumour ◽

Cubital Tunnel ◽

Malignant Neoplasms ◽

Entrapment Neuropathies ◽

First Case ◽

Tunnel Syndrome

Cubital tunnel syndrome is one of the most common entrapment neuropathies in adults. It is mainly caused by the depression of ulnar nerve from normal structures at the elbow area. Despite the fact that several pathgological entities can be potential mechanisms of the syndrome, the pathogenesis due to benign or malignant neoplasms is extremely rare. In the present report we describe the first case of cubital tunnel syndrome due to giant cell tumour of the tendon sheaths.

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Drivers underpinning the malignant transformation of giant cell tumour of bone

10.1101/2020.06.14.20129809 ◽

2020 ◽

Cited By ~ 1

Author(s):

Matthew W. Fittall ◽

Peter Ellery ◽

Iben Lyskjær ◽

Patrick Lombard ◽

Jannat Ijaz ◽

...

Keyword(s):

Giant Cell ◽

Malignant Transformation ◽

Giant Cell Tumour ◽

Histone Gene ◽

Cell Tumour ◽

Methylation Patterns

The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique G34W oncohistone mutation in the H3.3 histone gene. Here we reveal the genomic and methylation patterns underlying the rare clinical phenomena of benign metastases and malignant transformation of GCTB.

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Malignant transformation in a fatal case of giant cell tumour of the sacrum.

Postgraduate Medical Journal ◽

10.1136/pgmj.71.835.301 ◽

1995 ◽

Vol 71 (835) ◽

pp. 301-302 ◽

Cited By ~ 2

Author(s):

J. P. Crew ◽

M. Flannery ◽

B. Manners ◽

C. J. Coates

Keyword(s):

Giant Cell ◽

Malignant Transformation ◽

Giant Cell Tumour ◽

Fatal Case ◽

Cell Tumour

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PROSPECTIVE INTERVENTIONAL STUDY OF ASSESS FUNCTIONAL OUTCOME OF GIANT CELL TUMOUR OF DISTAL END RADIUS TREATED BY EN BLOE RESECTION AND RECONSTRUCTION BY ULNAR TRANSLOCATION

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i8.2130 ◽

2021 ◽

Vol 5 (8) ◽

Author(s):

Suresh Bishnoi ◽

Sanjay Yadav ◽

Pankaj Jain ◽

Shreekant Meena

Keyword(s):

Giant Cell ◽

Soft Tissues ◽

Giant Cell Tumour ◽

Wrist Joint ◽

Cell Tumour ◽

Recurrence Rates ◽

Superficial Infection ◽

Musculoskeletal Tumor ◽

Musculoskeletal Tumor Society ◽

Msts Score

Background: Giant cell tumour (GCT) of bone is a relatively rare, locally aggressive benign neoplasm associated with a wide pathological spectrum, ranging from latent benign to highly recurrent and, occasionally, malignant metastatic potential. Methods: This retrospective study was conducted on 30 hospitalized patients for surgery in in Jaipur. We followed up all patients with GCT of the distal radius who were treated with en bloc excision and custom prosthetic replacement. All cases were evaluated based on clinical and radiological examinations, passive range of motion (ROM) of the wrist joint, complications, and Musculoskeletal Tumor Society (MSTS) score. Results: Mean follow-up period was 52.36 months, mean resected length of the radius was 7.11±2.31 cm. One patient had tumor recurrence in the soft tissues after 16.32±2.31 months (recurrence rate 10.00 %). No patient had fracture, recurrence in the bone, metastases, or immune rejection. No complications were seen, such as loosening, rupture, or dislocation of the custom prosthesis. One patient developed superficial infection at the operative site which resolved after a course of antibiotics for 4 weeks. One patient experienced pain, which could be endured without the need for analgesics. Average ROM was 40.6° of dorsiflexion, 29.8° of volar flexion, 46.2° of supination, and 37.8° of pronation. Mean grip strength was 70 % (41–84 %). Overall revised MSTS score averaged 81.36 % with one being excellent, five good, and five satisfactory. Conclusion: The optimal treatment for GCTs arising around the knee remains controversial. Despite the trend towards better oncological control of this tumour after wide resections, the recurrence rates achieved through a more conservative procedure such as the curettage-based interventions seem to be acceptable. Additionally, curettage and local adjuvants allow for overall better function of the knee, in particular with proximal tibia GCTs. Keywords: GCT, MSTS, ROM

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