scholarly journals Complete cognitive recovery in a severe case of anti-N-methyl-d-aspartate receptor encephalitis treated with electroconvulsive therapy

2020 ◽  
Vol 13 (2) ◽  
pp. e233772
Author(s):  
Cæcilie Leding ◽  
Lisbet Marstrand ◽  
Anders Jorgensen
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Neuropsychiatric Symptoms ◽  
Behavioural Change ◽  
Severe Case ◽  
Cognitive Outcome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cognitive Domains ◽  
Nmda Receptor Encephalitis

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis usually presents with prominent neuropsychiatric symptoms and many patients experience cognitive sequelae. Electroconvulsive therapy (ECT) has been suggested as a part of the treatment, particularly for catatonia, but concerns that ECT may worsen the cognitive function and long-term outcome may limit its use. We present a case of anti-NMDA receptor encephalitis with severe neuropsychiatric manifestations including refractory catatonia and behavioural change. A pre-ECT neuropsychological assessment revealed dysfunction in multiple cognitive domains in spite of intensive pharmacological treatment. Twenty days after the ninth and last ECT treatment, the patient underwent the same neuropsychological tests, which showed normalised test results within all cognitive domains and no need of rehabilitation. The case demonstrates that the use of ECT in anti-NMDA receptor encephalitis with severe pretreatment cognitive dysfunction can be associated with a highly favourable cognitive outcome.

scholarly journals Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

2013 ◽  
Vol 12 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Maarten J Titulaer ◽  
Lindsey McCracken ◽  
Iñigo Gabilondo ◽  
Thaís Armangué ◽  
Carol Glaser ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Nmda Receptor ◽  
Observational Cohort Study ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Nmda Receptor Encephalitis ◽  
Observational Cohort

scholarly journals Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal

Neurology ◽  
2007 ◽  
Vol 70 (7) ◽  
pp. 504-511 ◽  
Author(s):  
T. Iizuka ◽  
F. Sakai ◽  
T. Ide ◽  
T. Monzen ◽  
S. Yoshii ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Tumor Removal ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Nmda Receptor Encephalitis

Electroconvulsive therapy for anti-N-methyl-d-aspartate (NMDA) receptor encephalitis: A systematic review of cases

2019 ◽  
Vol 12 (2) ◽  
pp. 329-334 ◽  
Author(s):  
Nicola Warren ◽  
Vanessa Grote ◽  
Cullen O'Gorman ◽  
Dan Siskind
Keyword(s):  
Systematic Review ◽  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Nmda Receptor Encephalitis

scholarly journals Long-term neurodevelopment in children born with esophageal atresia: a systematic review

2021 ◽  
Author(s):  
Camille E van Hoorn ◽  
Chantal A ten Kate ◽  
Andre B Rietman ◽  
Leontien C C Toussaint-Duyster ◽  
Robert Jan Stolker ◽  
...  
Keyword(s):  
Cognitive Development ◽  
Motor Function ◽  
Esophageal Atresia ◽  
Current Knowledge ◽  
Neurodevelopmental Outcome ◽  
Cognitive Outcome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
The One

Summary Background Although the survival rate of esophageal atresia (EA) has increased to over 90%, the risk of functional long-term neurodevelopmental deficits is uncertain. Studies on long-term outcomes of children with EA show conflicting results. Therefore, we provide an overview of the current knowledge on the long-term neurodevelopmental outcome of children with EA. Methods We performed a structured literature search in Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google scholar on November 8, 2020 with the keywords ‘esophageal atresia’, ‘long-term outcome’, ‘motor development’, ‘cognitive development’, and ‘neurodevelopment’. Results The initial search identified 945 studies, of which 15 were included. Five of these published outcomes of multiple tests or tested at multiple ages. Regarding infants, one of six studies found impaired neurodevelopment at 1 year of age. Regarding preschoolers, two of five studies found impaired neurodevelopment; the one study assessing cognitive development found normal cognitive outcome. Both studies on motor function reported impairment. Regarding school-agers, the one study on neurodevelopmental outcome reported impairment. Cognitive impairment was found in two out of four studies, and motor function was impaired in both studies studying motor function. Conclusions Long-term neurodevelopment of children born with EA has been assessed with various instruments, with contrasting results. Impairments were mostly found in motor function, but also in cognitive performance. Generally, the long-term outcome of these children is reason for concern. Structured, multidisciplinary long-term follow-up programs for children born with EA would allow to timely detect neurodevelopmental impairments and to intervene, if necessary.

Anti-nmda Receptor Encephalitis: A Masquerade Ball Of Neuropsychiatric Symptoms

2018 ◽  
Vol 28 (2) ◽  
pp. 173-173 ◽  
Author(s):  
Adeel Arshad ◽  
Shahzaib Nabi ◽  
Muhammad Zahid
Keyword(s):  
Nmda Receptor ◽  
Neuropsychiatric Symptoms ◽  
Nmda Receptor Encephalitis

scholarly journals Electroconvulsive therapy can improve psychotic symptoms in anti-NMDA-receptor encephalitis

2012 ◽  
Vol 66 (3) ◽  
pp. 242-243 ◽  
Author(s):  
Takuya Matsumoto ◽  
Kenji Matsumoto ◽  
Toshiyuki Kobayashi ◽  
Satoshi Kato
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Psychotic Symptoms ◽  
Nmda Receptor Encephalitis

scholarly journals Battey’s operation as a treatment for hysteria: a review of a series of cases in the nineteenth century

2019 ◽  
Vol 31 (1) ◽  
pp. 55-66
Author(s):  
Tomoko Komagamine ◽  
Norito Kokubun ◽  
Koichi Hirata
Keyword(s):  
Nineteenth Century ◽  
Differential Diagnosis ◽  
Nmda Receptor ◽  
Neuropsychiatric Symptoms ◽  
Acute Onset ◽  
Cystic Degeneration ◽  
Late Nineteenth Century ◽  
Paraneoplastic Encephalitis ◽  
Nmda Receptor Encephalitis ◽  
Late Nineteenth

Ovarian resection as a treatment for hysteria, called ‘Battey’s operation’ or ‘normal ovariotomy’, was performed in the nineteenth century. Battey later reported that the resected ovaries appeared to have ‘cystic degeneration’. Currently, patients with acute neuropsychiatric symptoms are screened for teratomas for the differential diagnosis of anti-NMDA receptor encephalitis. There is now a hypothesis that ovarian lesions resulting in paraneoplastic encephalitis were among the patients who underwent Battey’s operation. We identified 94 published cases of Battey’s operation for neuropsychiatric symptoms in the late nineteenth century. Among 36 cases with detailed descriptions, we found 3 patients who showed acute onset neuropsychiatric symptoms with macropathological ovarian findings that were compatible with teratoma. They showed favourable prognoses after surgery and might have motivated the surgeons to perform the operation.

scholarly journals Pearls & Oy-sters: Electroconvulsive therapy in anti-NMDA receptor encephalitis

Neurology ◽  
2010 ◽  
Vol 75 (10) ◽  
pp. e44-e46 ◽  
Author(s):  
H. M. H. Braakman ◽  
V. M. P. Moers-Hornikx ◽  
B. M. G. Arts ◽  
R. M. M. Hupperts ◽  
J. Nicolai
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Nmda Receptor Encephalitis

scholarly journals Anti-NMDA Receptor Encephalitis in a Patient with a History of Autism Spectrum Disorder

2020 ◽  
Vol 10 (3) ◽  
pp. 231-235
Author(s):  
Xavier Diao ◽  
Milana Mor
Keyword(s):  
Autism Spectrum Disorder ◽  
Nmda Receptor ◽  
Neuropsychiatric Symptoms ◽  
Antipsychotic Agents ◽  
Altered Mental Status ◽  
Autism Spectrum ◽  
Acute Onset ◽  
Spectrum Disorder ◽  
Nmda Receptor Encephalitis ◽  
History Of

Background: Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune syndrome characterized by a well-described constellation of neuropsychiatric symptoms. Its exact pathophysiology is poorly understood, but it is thought to be mediated by autoantibodies against NMDA (N-methyl-D-aspartate)-type glutamate receptors in the central nervous system. There is ongoing literature to suggest that patients with autism spectrum disorder (ASD) have evidence of neuroinflammation—or by definition, encephalitis. Objective: To investigate the link between autism spectrum disorder and autoimmune encephalitides. Methods: We present a case of anti-NMDA receptor encephalitis in a patient with autism spectrum disorder. “OP” is a 16-year-old male with a history of attention-deficit/ hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) who presented with a 3-day history of acute-onset altered mental status, electroencephalogram (EEG)-corroborated seizures, and slurred speech. Laboratory studies were significant for serum- and cerebrospinal fluid (CSF)-positive NMDA antibodies. The child psychiatry consult-liaison service was consulted for significant agitation and behavioral dyscontrol. We recommended 1:1 observation for safety, as well as antipsychotic agents titrated to clinical effect. The patient had a protracted hospital course, but was eventually discharged to an acute rehabilitation facility for continued stabilization and therapy. Conclusion: It remains to be seen if the relation between encephalitis and ASD is uni- or bidirectional, that is: whether children with ASD have a genetic diathesis to developing encephalitides (such as those mediated by the NMDAR), or conversely, if deranged or inflamed neuroreceptor processes are implicated in the development of ASD.

Sign in / Sign up

Export Citation Format

Share Document