Subcutaneous panniculitis-like T cell lymphoma arising in association with chronic lymphocytic leukaemia

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell malignancy of cytotoxic T cell origin. It is frequently associated with autoimmune diseases. It is known to preferentially involve subcutaneous adipose tissue and histologically resembles lupus panniculitis. The aetiology and risk factors of SPTCL are unclear and there are limited studies available since this entity was initially described in 2001. There are even fewer case reports describing the association between SPTCL and chronic lymphocytic leukemia (CLL). In this article, we present a case of SPTCL arising during treatment for CLL. We conducted an extensive review of literature to delve into the possible risk factors for SPTCL development in association with CLL, including pre-existing haematological malignancies, autoimmune conditions, immunomodulation and immunosuppressive chemotherapy.

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Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis

Case Reports in Oncological Medicine ◽

10.1155/2020/8569426 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Negin Rahmani ◽

Yahya Daneshbod ◽

Hadi Mirfazaelian ◽

Elnaz Vahidi ◽

Sadegh Shirian

Keyword(s):

Abdominal Pain ◽

T Cell ◽

Acute Appendicitis ◽

Treatment Guidelines ◽

Cell Lymphoma ◽

Case Reports ◽

Lower Abdominal Pain ◽

T Cell Lymphoma ◽

Cytotoxic T Cell ◽

Pathology Report

Introduction. Lymphoma of the appendix is a rare cause of acute appendicitis; however, acute appendicitis is a common first manifestation of appendiceal lymphomas. Cytotoxic peripheral T cell lymphoma (PTCL) is a type of aggressive non-Hodgkin lymphoma that portends a generally poor outcome. Cytotoxic PTCL of the appendix is extremely rare with few cases reported in the literature. Case Presentation. This is the report of a 23-year-old man who had experienced lower abdominal pain for three months before presenting to the emergency department with severe right lower abdominal pain, nausea, vomiting, and anorexia since the day prior to admission. The patient was diagnosed with acute appendicitis, and the pathology report confirmed cytotoxic PTCL of the appendix. Conclusion. Patients with appendiceal PTCL commonly present with signs and symptoms of acute appendicitis due to luminal obstruction by the tumor. Therefore, appendiceal tumors such as PTCL should be considered in the differential diagnosis of patients presenting as acute appendicitis. In addition, since there is no standard chemotherapy regimen for cytotoxic PTCL, this and other case reports hopefully help in providing the clinical evidence needed for establishing appropriate treatment guidelines.

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Subcutaneous panniculitis-like T cell lymphoma: a rare entity and its cryptic journey through pregnancy

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20214215 ◽

2021 ◽

Vol 7 (6) ◽

pp. 866

Author(s):

Surender Singh ◽

Siddhi B. Chikhalkar ◽

Aditi A. Shende ◽

Vidya D. Kharkar ◽

Prateek Oswal

Keyword(s):

T Cell ◽

Lupus Erythematosus ◽

Hemophagocytic Syndrome ◽

Cell Lymphoma ◽

Favourable Outcome ◽

T Cell Lymphoma ◽

Lupus Panniculitis ◽

T Cell Lymphomas ◽

Oral Steroids ◽

Subcutaneous Adipose

<p class="abstract">Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of skin lymphoma that primarily is localized to the subcutaneous adipose tissue and accounts for less than 1% of all peripheral T-cell lymphomas. It presents with multiple subcutaneous nodules or plaques on extremities and has poor prognosis if accompanied by hemophagocytic syndrome. Differential diagnosis is panniculitis, lupus panniculitis and leprosy. We report such a rare case of a female with lupus erythematosus (LE) panniculitis like presentation with favourable outcome to oral steroids in pregnancy.</p>

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