scholarly journals Adsorption of Thiocyanate to the Plasma Proteins : With Special Reference to the Distribution of this Ion between Aqueous Humour and Plasma

1955 ◽  
Vol 39 (11) ◽  
pp. 681-684 ◽  
Author(s):  
H. Davson
Keyword(s):  
Special Reference ◽  
Plasma Proteins ◽  
Aqueous Humour

Bindings of plasma proteins to streptococci of serological group L with special reference to their immunoglobulin G Fc-receptor activity

1988 ◽  
Vol 34 (1) ◽  
pp. 1-5 ◽  
Author(s):  
C. Lämmler ◽  
P. Schaufuß ◽  
C. Frede ◽  
H. Blobel
Keyword(s):  
Affinity Chromatography ◽  
Special Reference ◽  
Molecular Mass ◽  
Immunoglobulin G ◽  
Binding Sites ◽  
Plasma Proteins ◽  
Fc Receptors ◽  
Streptococcus Dysgalactiae ◽  
Serological Group ◽  
Ig G

Of 33 streptococcal cultures belonging to serological group L, all bound human immunoglobulin (Ig) G, fibrinogen, and fibronectin; 32 bound bovine IgG; 31 bound α2-macroglobulin; 5 bound albumin; and none bound either haptoglobin or IgA. The binding sites for IgG could be isolated from the L streptococci by trypsinization and purified by affinity chromatography on human IgG – Sepharose®. The purified Fc receptors reacted with IgG subclasses 1, 2, 3, 4 of humans, 1 and 2 of bovines, ovines, and caprines as well as a, b, c, and T of equines. They had a molecular mass of approximately 49 000 Da. Thus, the Fc receptors from L streptococci corresponded to type III Fc receptors of Streptococcus dysgalactiae.

The choroid plexus in fetal sheep during development with special reference to intracellular plasma proteins

1983 ◽  
Vol 8 (1) ◽  
pp. 77-88 ◽  
Author(s):  
Marianne Jacobsen ◽  
Kjeld Møllgård ◽  
Margaret L. Reynolds ◽  
Norman R. Saunders
Keyword(s):  
Special Reference ◽  
Choroid Plexus ◽  
Plasma Proteins ◽  
Fetal Sheep

scholarly journals Sanctuary sites and compartments: deciphering the enigma

2018 ◽  
Vol 7 (7) ◽  
pp. 1208
Author(s):  
Avishek Amar
Keyword(s):  
Plasma Proteins ◽  
Aqueous Humour ◽  
Acquired Resistance ◽  
The Body ◽  
Major Barrier ◽  
Development Of Resistance ◽  
Immunodeficiency Virus ◽  
Tissue System ◽  
Common Observation ◽  
Adipose Cells

It has been a common observation that many drugs get accumulated in the body at certain sites labelled as anatomical or physiological compartments where they are not expected to exert their desired effect. While the field of pharmacology considers these so-called sites or imaginary compartments as “sanctuary compartments” which could comprise of specialised tissue system where drugs could bind to tissue proteins or nucleoproteins, adipose cells serving as reservoir for extensively lipid soluble drugs, aqueous humour, cerebrospinal fluid, bones, and even plasma proteins, the reach and impact of the sanctuary compartments or sanctuary sites (which is the more preferred and broader term) has grown beyond that and spread extensively. Now, it is not just about certain drugs finding safe haven in these sanctuary compartments but also about certain disease conditions like HIV infection and cancer doing the same. Evidence has been accumulating regarding the fact that human immunodeficiency virus and various type of cancer cells have been using these compartments or sites to avoid being exposed to drugs which cannot penetrate well into such sanctuary sites. This phenomenon over the period of time has culminated in the development of resistance towards anti-retroviral and anti-neoplastic drugs to name a few. This means of acquired resistance is proving to be a major barrier to providing effective treatment to the patients. This review focusses on sanctuary compartments, their basic idea, the benefits associated with them, the challenges it poses to modern day medicine and finally, the possible methods of overcoming those challenges by attempting to un-sanctify the sanctuary compartments.

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