Effect of quadrivalent HPV vaccination on HPV related disease in women treated for cervical or vulvar/vaginal disease

Objectives: To investigate the acceptability of human papillomavirus (HPV) vaccination among men who have sex with men (MSM) and its associated factors.Methods: We searched studies written in English in PubMed, EMBASE, and Web of Science with no geographical or time restrictions. We evaluated the quality of the included literature. We calculated the pooled acceptability and performed meta-analysis of selected studies, including factors associated with the acceptability among MSM, using Review Manager (v5.3).Results: The acceptability among the 15 studies (n = 8,658) was 50% (95% CI: 0.27–0.72). The meta-analysis of seven articles (n = 4,200) indicated that having a college or higher degree (OR = 1.62, 95% CI: 1.35–1.95), disclosure of sexual orientation to healthcare professionals (HCPs; OR = 2.38, 95% CI: 1.47–3.86), vaccination with at least one dose for hepatitis A or B (OR = 2.10, 95% CI: 1.42–3.10), awareness of HPV (OR = 1.85, 95% CI: 1.21–2.83), knowledge of HPV (SMD = 0.28, 95% CI: 0.16–0.39), perceived susceptibility to HPV infection (SMD = 0.31, 95% CI: 0.11–0.50), and perceived severity of HPV-related disease (SMD = 0.40, 95% CI: 0.28–0.51) can promote acceptance of HPV vaccines. Meanwhile, people who have had unprotected anal sex or have more sex partners tend to have low acceptance of HPV vaccines.Conclusions: HPV education should be actively promoted according to the factors that influence the acceptability of HPV vaccines among the MSM population. HPV education should be especially aimed at people with low academic qualifications and people with risky sexual behaviors, and should emphasize the aspects of susceptibility to and severity of HPV-related disease. More intervention trials should be conducted to increase the credibility of the results.

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Ten years of HPV vaccination in the Netherlands: current evidence and future challenges in HPV-related disease prevention

Expert Review of Vaccines ◽

10.1080/14760584.2018.1547196 ◽

2018 ◽

Vol 17 (12) ◽

pp. 1093-1104 ◽

Cited By ~ 4

Author(s):

V. Qendri ◽

T. M. Schurink-Van ’t Klooster ◽

J. A. Bogaards ◽

J. Berkhof

Keyword(s):

The Netherlands ◽

Disease Prevention ◽

Hpv Vaccination ◽

Current Evidence ◽

Related Disease ◽

Future Challenges

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Providers’ Attitudes Toward Human Papillomavirus Vaccination in Young Men

American Journal of Men s Health ◽

10.1177/1557988312438911 ◽

2012 ◽

Vol 6 (4) ◽

pp. 320-323 ◽

Cited By ~ 48

Author(s):

Rebecca B. Perkins ◽

Jack A. Clark

Keyword(s):

Human Papillomavirus ◽

Family Medicine ◽

Hpv Vaccination ◽

Young Men ◽

Human Papillomavirus Vaccination ◽

Related Disease ◽

New Guidelines

Providers’ attitudes toward male human papillomavirus (HPV) vaccination may influence the implementation of new guidelines. Although 24 of 31 (77%) Pediatric and Family Medicine providers interviewed between 2009 and 2010 favored vaccinating males, only 3 (12%) offered vaccination. Providers who did not offer vaccination felt that parents would not be interested in vaccinating sons and were largely unaware of serious HPV-related disease in males.

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The impact of 10 years of human papillomavirus (HPV) vaccination in Australia: what additional disease burden will a nonavalent vaccine prevent?

Eurosurveillance ◽

10.2807/1560-7917.es.2018.23.41.1700737 ◽

2018 ◽

Vol 23 (41) ◽

Cited By ~ 48

Author(s):

Cyra Patel ◽

Julia ML Brotherton ◽

Alexis Pillsbury ◽

Sanjay Jayasinghe ◽

Basil Donovan ◽

...

Keyword(s):

Vaccination Programme ◽

Disease Burden ◽

Hpv Vaccination ◽

Genital Warts ◽

Hpv Infection ◽

High Coverage ◽

Related Disease ◽

Hpv Prevalence ◽

Vaccine Type ◽

The Impact

Background: A National human papilloma virus (HPV) Vaccination Programme for the prevention of HPV infection and associated disease using the quadrivalent HPV vaccine (4vHPV) has been funded and implemented in Australia since 2007, initially for girls only and extended to boys in 2013, with uptake rates among the highest observed worldwide. Aim: We report on the impact of this national programme on HPV prevalence and associated disease burden and estimate the potential impact of adopting a nonavalent HPV (9vHPV) vaccine. Methods: We performed a non-systematic literature review of studies measuring the burden of HPV-associated disease and infection in Australia before and after introduction of HPV vaccination. We also included key national reports with estimates of HPV-related disease burden. Results: Substantial declines in high-grade cervical disease and genital warts among vaccine-eligible women have been observed. Reductions in genital warts incidence and HPV prevalence among heterosexual men of similar age were observed before introduction of the male vaccination programme, indicating a substantial herd effect. 9vHPV vaccine is expected to prevent up to 90% of cervical and 96% of anal cancers. Of an estimated 1,544 HPV-associated cancers in 2012, 1,242 would have been preventable by the 4vHPV vaccine and an additional 187 anogenital cancers by the 9vHPV vaccine. Conclusions: Vaccination using 4vHPV vaccine has had a large demonstrable impact on HPV-related disease in Australia. A switch to 9vHPV could further reduce the HPV-associated cancer burden. With continued high coverage among both males and females, elimination of vaccine-type HPV disease seems achievable in Australia.

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Time to consider a targeted HPV vaccination programme for male military recruits

Journal of the Royal Army Medical Corps ◽

10.1136/jramc-2017-000802 ◽

2017 ◽

Vol 164 (4) ◽

pp. 284-286 ◽

Cited By ~ 1

Author(s):

William M J Sharp ◽

T Nadarzynski ◽

N E Dufty

Keyword(s):

Vaccination Programme ◽

Hpv Vaccination ◽

Herd Immunity ◽

Human Papillomaviruses ◽

Military Population ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Related Disease ◽

Military Recruits ◽

The Uk

Human papillomaviruses (HPV) are the most common type of sexually transmitted infection in men but also related to high-risk cancers. This article considers the epidemiology of HPV in the male military population, the UK vaccination programme and the current UK Joint Committee on Vaccination and Immunisation recommendations. Military men may not benefit from HPV herd immunity and may have a different risk profile; vaccination may in turn reduce the operational burden of HPV-related disease within this population. Military men may benefit from a targeted vaccination programme, and the paper calls for urgent consideration of approaches that could protect them from acquiring HPV.

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Effects of Human Papillomavirus–Related Disease on Patient Knowledge and Practices Regarding HPV Vaccination [32G]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000533382.81741.3f ◽

2018 ◽

Vol 131 ◽

pp. 83S-84S

Author(s):

Maame A. Coleman ◽

Emily Cohen ◽

Haleh Sangi-Haghpeykar

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Patient Knowledge ◽

Related Disease

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Human papillomavirus and surgical smoke: a systematic review

Occupational and Environmental Medicine ◽

10.1136/oemed-2019-106333 ◽

2020 ◽

Vol 77 (12) ◽

pp. 809-817 ◽

Cited By ~ 1

Author(s):

Andrew Fox-Lewis ◽

Caroline Allum ◽

David Vokes ◽

Sally Roberts

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Hpv Infection ◽

Smoke Exposure ◽

Upper Airways ◽

Surgical Smoke ◽

Hpv Dna ◽

Local Exhaust Ventilation ◽

Related Disease ◽

Ovid Medline

ObjectiveTo evaluate what is currently known about the risk to surgeons and other operating theatre (OT) staff of human papillomavirus (HPV) transmission and HPV-related disease following surgical smoke exposure.MethodsA systematic literature search of Embase and Ovid-MEDLINE was undertaken for primary studies relevant to the presence of HPV in surgical smoke, contamination of OT staff with HPV after performing or attending smoke-generating surgical procedures, and the presence of HPV or HPV-related disease in OT staff following occupational surgical smoke exposure. Additional articles were identified by searching the reference lists of relevant published papers.ResultsTwenty-one relevant articles were identified. These demonstrate that surgical smoke from the treatment of HPV-related lesions can contain HPV DNA, and that this can contaminate the upper airways of OT staff. Whether this corresponds to infectious virus is not known. Increased prevalence of HPV infection or HPV-related disease in OT staff following occupational exposure to surgical smoke has not been convincingly shown.ConclusionsWhile HPV transmission to OT staff from surgical smoke remains unproven, it would be safest to treat surgical smoke as potentially infectious. Necessary precautions should be taken when performing smoke-generating procedures, consisting of: (1) local exhaust ventilation, (2) general room ventilation and (3) full personal protective equipment including a fit tested particulate respirator of at least N95 grade. There is currently insufficient evidence to recommend HPV vaccination for OT staff or to state that the above precautions, when used properly, would not be effective at preventing HPV transmission from surgical smoke.

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