Effect of alcohol consumption and the presence of fatty liver on the risk for incident type 2 diabetes: a population-based longitudinal study

IntroductionBoth fatty liver disease (FLD) and alcohol consumption have been reported to affect incident type 2 diabetes mellitus. The aim of this study was to evaluate the combined effect of FLD and alcohol consumption on incident type 2 diabetes.Research design and methodsIn this historical cohort study involving 9948 men, we investigated the influence of the presence of FLD and the grades of alcohol consumption on incident type 2 diabetes using Cox proportional hazards models. We categorized the participants into the following four groups: none or minimal alcohol consumption, <40 g/week; light, 40–140 g/week; moderate, 140–280 g/week; or heavy alcohol consumption, >280 g/week. FLD was diagnosed by abdominal ultrasonography.ResultsDuring the median 6.0-year follow-up, 568 participants developed type 2 diabetes. Heavy alcohol consumers with FLD showed a higher risk for developing type 2 diabetes compared with the other groups. Moderate alcohol consumers without FLD had a significantly higher risk for developing incident type 2 diabetes, compared with none or minimal and light alcohol consumers without FLD. In contrast, there was no apparent difference in the risk for incident type 2 diabetes between none or minimal, light, and moderate alcohol consumers with FLD. Furthermore, there was no statistically significant difference in the risk for incident type 2 diabetes between a moderate and heavy alcohol consumer without FLD and a none or minimal, light, and moderate alcohol consumer with FLD.ConclusionsTo prevent incident type 2 diabetes, we should acknowledge that the impact of alcohol consumption may vary in the presence of FLD.

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Association between alcohol consumption and plasma fetuin-A and its contribution to incident type 2 diabetes in women

Diabetologia ◽

10.1007/s00125-013-3077-8 ◽

2013 ◽

Vol 57 (1) ◽

pp. 93-101 ◽

Cited By ~ 15

Author(s):

Sylvia H. Ley ◽

Qi Sun ◽

Monik C. Jimenez ◽

Kathryn M. Rexrode ◽

JoAnn E. Manson ◽

...

Keyword(s):

Type 2 Diabetes ◽

Alcohol Consumption ◽

Fetuin A ◽

Incident Type ◽

Incident Type 2 Diabetes

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Association of Alcohol Drinking With Incident Type 2 Diabetes and Pre-diabetes: the Guangzhou Biobank Cohort Study

10.21203/rs.3.rs-955149/v1 ◽

2021 ◽

Author(s):

Mei Jiao Li ◽

Jing Ren ◽

Wei Sen Zhang ◽

Chao Qiang Jiang ◽

Ya Li Jin ◽

...

Keyword(s):

Type 2 Diabetes ◽

Genetic Polymorphisms ◽

Impaired Fasting Glucose ◽

Alcohol Drinking ◽

Fasting Glucose ◽

Heavy Alcohol ◽

Incident Type ◽

Incident Type 2 Diabetes

Abstract Background To examine associations of baseline alcohol drinking with incident type 2 diabetes or impaired fasting glucose, and explore whether the associations were modified by genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B).Methods Information of alcohol consumption was collected at baseline from 2003 to 2008. Incident type 2 diabetes was defined as fasting glucose ≥7.0 mmol/l or post-load glucose ≥11.1 mmol/l at follow-up examination (2008-2012), self-reported type 2 diabetes and/or initiation of hypoglycemia medication or insulin during follow-up. Impaired fasting glucose was defined as fasting glucose ≥5.6 mmol/l and <7 mmol/l. Results Of 15,716 participants without diabetes and 11,232 participants without diabetes and impaired fasting glucose at baseline, 1,624 (10.33%) developed incident type 2 diabetes, and 1,004 (8.94%) developed incident impaired fasting glucose during average 4 years of follow-up. After adjusting for sex, age, education, occupation, personal annual income, smoking, physical activity, body mass index, waist/hip ratio, health status, family history of diabetes, compared with never drinking, occasional or moderate alcohol drinking was not associated with risk of incident type 2 diabetes+impaired fasting glucose (odds ratio (OR) 1.08, 95% confidence interval (CI) 0.94-1.25, and 0.89 (0.68-1.16), respectively), but heavy alcohol drinking was associated with a higher risk of incident type 2 diabetes+impaired fasting glucose (1.83, 1.25-2.69). No interactions of sex, overweight/obesity and genetic polymorphisms of ADH1B or ALDH2 genes with alcohol drinking on incident type 2 diabetes and/or impaired fasting glucose were found (p for interaction from 0.12 to 0.81). Conclusions Our results support a detrimental effect of heavy alcohol use on impaired fasting glucose and type 2 diabetes. No protective effect was found for those carrying lower risk alleles for ADH1B and ALDH2 genes.

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Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis

American Journal of Clinical Nutrition ◽

10.3945/ajcn.115.114389 ◽

2016 ◽

Vol 103 (3) ◽

pp. 818-829 ◽

Cited By ~ 88

Author(s):

Xiao-Hua Li ◽

Fei-fei Yu ◽

Yu-Hao Zhou ◽

Jia He

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Alcohol Consumption ◽

Dose Response ◽

Meta Analysis ◽

Incident Type ◽

Incident Type 2 Diabetes

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Fatty liver index is a risk determinant of incident type 2 diabetes in a metabolically healthy population with obesity

Obesity ◽

10.1002/oby.21483 ◽

2016 ◽

Vol 24 (6) ◽

pp. 1373-1379 ◽

Cited By ~ 18

Author(s):

Chang Hee Jung ◽

Yu Mi Kang ◽

Jung Eun Jang ◽

Jenie Yoonoo Hwang ◽

Eun Hee Kim ◽

...

Keyword(s):

Type 2 Diabetes ◽

Fatty Liver ◽

Healthy Population ◽

Incident Type ◽

Liver Index ◽

Fatty Liver Index ◽

Incident Type 2 Diabetes ◽

Metabolically Healthy

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Meta-analysis of the impact of alpha-glucosidase inhibitors on incident diabetes and cardiovascular outcomes

Cardiovascular Diabetology ◽

10.1186/s12933-019-0933-y ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 1

Author(s):

Ruth L. Coleman ◽

Charles A. B. Scott ◽

Zhihui Lang ◽

M. Angelyn Bethel ◽

Jaakko Tuomilehto ◽

...

Keyword(s):

Type 2 Diabetes ◽

Meta Analysis ◽

Random Effects Models ◽

Incident Type ◽

Glucosidase Inhibitors ◽

Incident Type 2 Diabetes ◽

Cv Disease ◽

The Impact ◽

Alpha Glucosidase

Abstract Background Alpha-glucosidase inhibitors (AGIs) have been shown to reduce incident type 2 diabetes but their impact on cardiovascular (CV) disease remains controversial. We sought to identify the overall impact of AGIs with respect to incident type 2 diabetes in individuals with impaired glucose tolerance (IGT), and CV outcomes in those with IGT or type 2 diabetes. Methods We used PubMed and SCOPUS to identify randomized controlled trials reporting the incidence of type 2 diabetes and/or CV outcomes that had compared AGIs with placebo in populations with IGT or type 2 diabetes, with or without established CV disease. Eligible studies were required to have ≥ 500 participants and/or ≥ 100 endpoints of interest. Meta-analyses of available trial data were performed using random effects models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident type 2 diabetes and CV outcomes. Results Of ten trials identified, three met our inclusion criteria for incident type 2 diabetes and four were eligible for CV outcomes. The overall HR (95% CI) comparing AGI with placebo for incident type 2 diabetes was 0.77 (0.67–0.88), p < 0.0001, and for CV outcomes was 0.98 (0.89–1.10), p = 0.85. There was little to no heterogeneity between studies, with I2 values of 0.03% (p = 0.43) and 0% (p = 0.79) for the two outcomes respectively. Conclusions Allocation of people with IGT to an AGI significantly reduced their risk of incident type 2 diabetes by 23%, whereas in those with IGT or type 2 diabetes the impact on CV outcomes was neutral.

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