415 The relationship of lingual frenulum and obstructive sleep apnoea (OSA) in children

Until now, the relationship of obstructive sleep apnoea (OSA) with diabetic retinopathy (DR) was controversial. This meta-analysis was performed to obtain definitive conclusion on this topic. Relevant articles were searched on databases of Pubmed, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The articles were selected according to inclusion and exclusion criteria. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the relationship of OSA with risk of DR.I2andPvalue were used to assess the presence of heterogeneity.I2≥ 50% orP<0.05indicated significant heterogeneity. Sensitivity analysis was performed to evaluate the robustness of pooled results. Begg’s funnel plot and Egger’s regression analysis were adopted to assess publication bias. 6 eligible studies were selected in the present meta-analysis. The pooled results indicated that OSA was significantly associated with increased risk of DR (OR = 2.01, 95% CI = 1.49–2.72). Subgroup analysis based on type of diabetes mellitus suggested that OSA was related to DR in both Type 1 and Type 2 diabetes mellitus. Sensitivity analysis demonstrated that pooled results were robust. No significant publication bias was observed (P=0.128). The results indicate that OSA is related to increased risk of DR.

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A dog model to investigate the relationship between obstructive sleep apnoea and blood pressure regulation

Journal of Sleep Research ◽

10.1111/j.1365-2869.1995.tb00194.x ◽

1995 ◽

Vol 4 ◽

pp. 89-92 ◽

Cited By ~ 2

Author(s):

C. P. O'DONNELL ◽

E. D. KING ◽

A. R. SCHWARTZ ◽

P. L. SMITH ◽

J. L. ROBOTHAM

Keyword(s):

Blood Pressure ◽

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Blood Pressure Regulation ◽

Pressure Regulation ◽

Dog Model ◽

Obstructive Sleep ◽

The Relationship

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Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders?

International Journal of Molecular Sciences ◽

10.3390/ijms21228779 ◽

2020 ◽

Vol 21 (22) ◽

pp. 8779

Author(s):

David Gozal ◽

Isaac Almendros ◽

Amanda I. Phipps ◽

Francisco Campos-Rodriguez ◽

Miguel A. Martínez-García ◽

...

Keyword(s):

Cancer Progression ◽

Experimental Studies ◽

Epidemiological Studies ◽

Sleep Apnoea ◽

Epidemiological Evidence ◽

Obstructive Sleep ◽

Cancer Types ◽

Relationship Of ◽

Risk Of Cancer ◽

The Relationship

Obstructive sleep apnoea (OSA) is a prevalent disorder associated with increased cardiovascular, metabolic and neurocognitive morbidity. Recently, an increasing number of basic, clinical and epidemiological reports have suggested that OSA may also increase the risk of cancer, and adversely impact cancer progression and outcomes. This hypothesis is convincingly supported by biological evidence linking certain solid tumours and hypoxia, as well as by experimental studies involving cell and animal models testing the effects of intermittent hypoxia and sleep fragmentation that characterize OSA. However, the clinical and epidemiological studies do not conclusively confirm that OSA adversely affects cancer, even if they hold true for specific cancers such as melanoma. It is likely that the inconclusive studies reflect that they were not specifically designed to test the hypothesis or because of the heterogeneity of the relationship of OSA with different cancer types or even sub-types. This review critically focusses on the extant basic, clinical, and epidemiological evidence while formulating proposed directions on how the field may move forward.

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