The natural history of left ventricular systolic function in Anderson-Fabry disease

Abstract BackgroundFunctional tricuspid regurgitation (FTR) is most often secondary to left-sided heart pathology involving the mitral valve. We studied the incidence, clinical impact, risk factors, and natural history of patients who developed FTR due to an ischemic cause of mitral regurgitation (IMR). We conducted a retrospective cohort study based on data collected from January 2012 to December 2014. Patients diagnosed with IMR were eligible for the study. The mean follow-up was five years.RESULTSThe study group consisted of 134 patients with IMR divided into two groups based on FTR development (FTR vs non-FTR group). Forty patients were diagnosed with FTR (30.1%). FTR patients were older (63.0 ± 10.4 vs 57.1 ± 11.0, respectively, p<0.05) with a high incidence of previous coronary artery disease (p<.006). Severe IMR, high pulmonary arterial pressure (PAP), and failed revascularization were significant predictors of FTR development (p<.001, p<.005, p<.003, respectively). Low systolic left ventricle function was a predictor for FTR progression.CONCLUSIONClinical observations showed that FTR development due to IMR is common. Elderly patients with ischemic heart disease are at particularly high risk. FTR incidence and severity are directly proportional to the severity of IMR. FTR tends to deteriorate in about one-fifth of IMR patients and is mainly affected by the left ventricular systolic function.

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48 N-terminal pro-brain natriuretic peptide in patients submitted to heart transplant with perserved left ventricular systolic function

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(04)90029-x ◽

2004 ◽

Vol 3 (1) ◽

pp. 10

Author(s):

S MARTINS

Keyword(s):

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Heart Transplant ◽

Systolic Function ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

Ventricular Systolic Function

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Clinical outcome of patients with severly reduced left ventricular systolic function after transcatheter aortic valve implantation

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0031-1297816 ◽

2012 ◽

Vol 60 (S 01) ◽

Author(s):

SM Ensminger ◽

J Ludwig ◽

S Loders ◽

F Einhaus ◽

WG Daniel ◽

...

Keyword(s):

Aortic Valve ◽

Clinical Outcome ◽

Transcatheter Aortic Valve Implantation ◽

Systolic Function ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

Ventricular Systolic Function ◽

Transcatheter Aortic Valve ◽

Aortic Valve Implantation ◽

Valve Implantation

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An Atypical Presentation of Acute Coronary Syndrome

European Cardiology Review ◽

10.15420/ecr.2012.8.1.67 ◽

2012 ◽

Vol 8 (1) ◽

pp. 67

Author(s):

Syed Khurram Mushtaq Gardezi ◽

Keyword(s):

Acute Coronary Syndrome ◽

Coronary Artery ◽

Systolic Function ◽

Artery Bypass ◽

Left Ventricular Systolic Function ◽

Regional Wall Motion ◽

Dobutamine Stress ◽

Left Ventricular ◽

Ventricular Systolic Function ◽

Coronary Syndrome

A 61-year-old man was admitted to hospital with severe occipital headache and weakness and numbness of the left arm. His electrocardiograms showed changes hinting at acute coronary syndrome (ACS). However, in view of his clinical presentation, he underwent tests for likely subarachnoid haemorrhage, but this was ruled out. The next day, he was referred to cardiology. A transthoracic echocardiogram showed reduced left ventricular systolic function along with regional wall motion abnormalities involving inferoposterior walls. The patient was treated as per the protocol for ACS. A dobutamine stress echocardiogram confirmed inferior myocardial infarction with evidence of myocardial viability in the affected left ventricular segments. Subsequent investigations confirmed three-vessel coronary artery disease and reduced left ventricular systolic function. The patient underwent successful coronary artery bypass grafting.

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