scholarly journals e0412 Obstructive sleep apnea syndrome is associated with increased risk of low-antiplatelet response of clopidogrel in patients with unstable angina

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A127-A127
Author(s):  
F. Xianghua ◽  
L. Shiqiang ◽  
W. Qian ◽  
G. Xinshun ◽  
W. Yanbo ◽  
...  
Angiology ◽  
2015 ◽  
Vol 67 (5) ◽  
pp. 461-470 ◽  
Author(s):  
Mustafa Saygin ◽  
Onder Ozturk ◽  
Mehmet Fehmi Ozguner ◽  
Ahmet Akkaya ◽  
Ercan Varol

We investigated the role of the red cell distribution width (RDW) and other parameters including platelet (PLT) count, mean platelet volume (MPV), and platelet distribution width (PDW) in patients with obstructive sleep apnea syndrome (OSAS) having cardiovascular diseases (CVDs). Patients (n = 142) having sleep disorders and who applied for a night polysomnography were included in this study. For statistical analysis, chi-square test, bivarite correlation, and logistic and stepwise regression tests were used. A positive correlation between RDW MPV, RDW, and body mass index as well as PLT and apnea–hypopnea index were observed. A negative correlation between AHI and PDW ( P = .041) and a positive correlation between AHI and PLT ( P = .010) were found in the patients ≥40 years old with CVD. The RDW was higher in patients ≥40 years old who had CVD ( P = .016), and 19% of them had RDW >14%. The PDW (odds ratio = 6.02 [95% confidence interval = 1.3-28.2], P = .023) appeared to be associated with increased risk of hyperlipidemia in patients with severe OSAS. If these results are confirmed, RDW could be used with other markers, especially PLT and PDW, in prediction of CVD in patients with severe OSAS.


2014 ◽  
Vol 155 (18) ◽  
pp. 703-707 ◽  
Author(s):  
Pálma Benedek ◽  
Gabriella Kiss ◽  
Eszter Csábi ◽  
Gábor Katona

Introduction: Treatment of pediatric obstructive sleep apnea syndrome is surgical. The incidence of postoperative respiratory complications in this population is 5–25%. Aim: The aim of the authors was to present the preoperative evaluation and monitoring procedure elaborated in Heim Pál Children Hospital, Budapest. Method: 142 patients were involved in the study. Patient history was obtained and physical examination was performed in all cases. Thereafter, polysomnography was carried out, the severity of the obstructive sleep apnea syndrome was determined, and the patients underwent tonsilloadenotomy. Results: 45 patients with mild, 50 patients with moderate and 47 patients with severe obstructive sleep apnea syndrome were diagnosed. There was no complication in patients with mild disease, while complications were observed in 6 patients in the moderate group and 24 patients in the severe group (desaturation, apnea, stridor, stop breathing) (p<0.000). In patients with severe obstructive sleep apnea syndrome, no significant difference was noted in preoperative apnoea-hypapnea index (p = 0.23) and in nadir oxygen saturation values (p = 0.73) between patients with and without complication. Conclusions: Patients with severe obstructive sleep apnea syndrome should be treated in hospital where pediatric intensive care unit is available. Orv. Hetil., 2014, 155(18), 703–707.


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