OP54 Assessing the possible role of intrauterine effects in the association between maternal smoking during pregnancy and offspring depression in the avon longitudinal study of parents and children using partner smoking as a negative control

AbstractBecause the demographic composition of neighborhoods and schools overlaps, their effects on educational attainment are not independent of each other. Throughout the early teenage years, the timing and duration of exposure to neighborhood and school contexts can vary, advocating for a longitudinal approach when studying schooling outcomes. This study uses Avon Longitudinal Study of Parents and Children data (N = 4502; 49% female) to examine how exposure to poverty between ages 10–16 predicts educational attainment. The results indicate that enduring exposure to neighborhood poverty relates to educational attainment, while timing does not. For school poverty, longer exposure is related to lower attainment, but earlier exposure has a stronger impact than later exposure. Adolescents who were exposed to poverty in both contexts for the full observation period had the lowest educational attainment. The findings highlight the importance of understanding when and how long adolescents are exposed to contextual poverty.

Download Full-text

Maternal smoking during pregnancy and offspring smoking initiation: assessing the role of intrauterine exposure

Addiction ◽

10.1111/add.12514 ◽

2014 ◽

Vol 109 (6) ◽

pp. 1013-1021 ◽

Cited By ~ 25

Author(s):

Amy E. Taylor ◽

Laura D. Howe ◽

Jon E. Heron ◽

Jennifer J. Ware ◽

Matthew Hickman ◽

...

Keyword(s):

Maternal Smoking ◽

Smoking Initiation ◽

Smoking During Pregnancy ◽

Intrauterine Exposure ◽

Maternal Smoking During Pregnancy

Download Full-text

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Human Molecular Genetics ◽

10.1093/hmg/ddu739 ◽

2014 ◽

Vol 24 (8) ◽

pp. 2201-2217 ◽

Cited By ~ 214

Author(s):

Rebecca C. Richmond ◽

Andrew J. Simpkin ◽

Geoff Woodward ◽

Tom R. Gaunt ◽

Oliver Lyttleton ◽

...

Keyword(s):

Dna Methylation ◽

Longitudinal Study ◽

Prenatal Exposure ◽

Maternal Smoking ◽

Parents And Children ◽

Avon Longitudinal Study

Download Full-text

Association between Breastfeeding and DNA Methylation over the Life Course: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Nutrients ◽

10.3390/nu12113309 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3309 ◽

Cited By ~ 1

Author(s):

Fernando Pires Hartwig ◽

George Davey Smith ◽

Andrew J. Simpkin ◽

Cesar Gomes Victora ◽

Caroline L. Relton ◽

...

Keyword(s):

Dna Methylation ◽

Longitudinal Study ◽

Negative Control ◽

Childhood And Adolescence ◽

Long Term Effects ◽

Parents And Children ◽

Short And Long Term ◽

The Life Course ◽

Avon Longitudinal Study

Background: Breastfeeding is associated with short and long-term health benefits. Long-term effects might be mediated by epigenetic mechanisms, yet the literature on this topic is scarce. We performed the first epigenome-wide association study of infant feeding, comparing breastfed vs non-breastfed children. We measured DNA methylation in children from peripheral blood collected in childhood (age 7 years, N = 640) and adolescence (age 15–17 years, N = 709) within the Accessible Resource for Integrated Epigenomic Studies (ARIES) project, part of the larger Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Cord blood methylation (N = 702) was used as a negative control for potential pre-natal residual confounding. Results: Two differentially-methylated sites presented directionally-consistent associations with breastfeeding at ages 7 and 15–17 years, but not at birth. Twelve differentially-methylated regions in relation to breastfeeding were identified, and for three of them there was evidence of directional concordance between ages 7 and 15–17 years, but not between birth and age 7 years. Conclusions: Our findings indicate that DNA methylation in childhood and adolescence may be predicted by breastfeeding, but further studies with sufficiently large samples for replication are required to identify robust associations.

Download Full-text