scholarly journals Leucocyte alkaline phosphatase and erythrocyte glucose-6-phosphate dehydrogenase in Down's Syndrome.

1967 ◽  
Vol 4 (4) ◽  
pp. 268-273 ◽  
Author(s):  
J Phillips ◽  
R M Herring ◽  
H O Goodman ◽  
J S King
Keyword(s):  
Alkaline Phosphatase ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Leucocyte Alkaline Phosphatase

STEROID MEDIATED CHANGES OF LEUCOCYTE ALKALINE PHOSPHATASE ACTIVITY IN DOWN'S SYNDROME

PEDIATRICS ◽  
1966 ◽  
Vol 38 (6) ◽  
pp. 996-1002
Author(s):  
Ernest E. McCoy ◽  
Manuchair Ebadi ◽  
Jack England
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
X Chromosome ◽  
Alkaline Phosphatase Activity ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Chromosome 21 ◽  
G6pdh Activity ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Leucocyte Alkaline Phosphatase

A study of the increase of leucocyte alkaline phosphatase (LAP) activity following oral anhydroxyprogesterone or intramuscular prednisolone was carried out in a group of Down's syndrome subjects and paired controls. The increase in LAP activity was greater in the Down's syndrome patients at p < .025 with anhydroxyprogestrone and at p < .005 with prednisolone. Simultaneous assays were carried out in another group of patients for LAP and the X chromosome-linked enzyme glucose 6-phosphate dehydrogenase (G6PDH). The increase in LAP activity was greater in Down's syndrome but the increase in G6PDH activity was similar in the two groups. Several possible reasons for the greater increase in LAP activity following the steroids were discussed. The authors favor the view that the increase is related to greater rates of synthesis of the enzyme in Down's syndrome and to trisomy for chromosome 21.

scholarly journals Lymphocyte and Granulocyte Enzyme Activity in Patients with Down’s Syndrome

Blood ◽  
1967 ◽  
Vol 30 (5) ◽  
pp. 669-673 ◽  
Author(s):  
HENRY L. NADLER ◽  
PATRICIA L. MONTELEONE ◽  
TOHRU INOUYE ◽  
DAVID YI-YUNG HSIA
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Acid Phosphatase ◽  
Blood Cells ◽  
Polymorphonuclear Leukocytes ◽  
White Blood Cells ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Phosphatase Alkaline

Abstract Patients with trisomic Down’s syndrome were found to have significant increases of acid phosphatase, alkaline phosphatase, and glucose-6-phosphate dehydrogenase in both lymphocytes and polymorphonuclear leukocytes separated from white blood cells by the procedure of Rabinowitz. The alteration in enzyme activities appears not to be directly related to genes located on the chromosome causing Down’s syndrome.

Biochemical and immunological characteristics of neutrophil alkaline phosphatase in Down's syndrome

1993 ◽  
Vol 218 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Henri A. Vergnes ◽  
Colette J. Denier ◽  
Andrée Brisson-Lougarre ◽  
Jean G. Grozdea ◽  
Georges Bourrouillou ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Neutrophil Alkaline Phosphatase

Characterization of platelet alkaline phosphatase in normal subjects and in trisomy 21 Down's syndrome patients

1971 ◽  
Vol 35 (1) ◽  
pp. 165-172 ◽  
Author(s):  
W. Tangheroni ◽  
A. Cao ◽  
S. Lungarotti ◽  
G. Coppa ◽  
S. De Virgiliis ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Trisomy 21 ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Normal Subjects

Leukocyte alkaline phosphatase in Down's syndrome

1966 ◽  
Vol 15 (3) ◽  
pp. 231-246 ◽  
Author(s):  
Giuseppe Cardinali ◽  
Giuliana Cardinali ◽  
Francesco Renzulli ◽  
Luigi Capotorti ◽  
Enzo Ferrante
Keyword(s):  
Alkaline Phosphatase ◽  
Down's Syndrome ◽  
Age Groups ◽  
Down’S Syndrome ◽  
Chromosome Analysis ◽  
Mean Value ◽  
Control Group ◽  
Normal Children ◽  
Leukocyte Alkaline Phosphatase ◽  
Or Genes

SUMMARYThe Authors studied the leukocyte alkaline phosphatase (LAP) activity in 40 subjects with Down's syndrome. The age of the patients ranged from one week to 15 years. Chromosome analysis was carried out in 13 cases. 42 normal children of the same age as the patients were used as controls. The mean value of LAP in the patients with Down's syndrome was 175.5 and in the control group 108.8. In the latter group the LAP activity was clearly influenced by the age; the highest values were obtained in children under 11 years of age. The regression coefficient of the LAP on the age in the control group was –3.73. In the patients with Down's syndrome the differences observed between the various age groups were not statistically significant.Chromosome studies showed a 21 trisomy in 12 cases; in one case a 15/21 translocation was found. The latter case presented an elevated LAP activity.The Authors support the hypothesis that the gene or genes controlling LAP activity are located in the 21 chromosome and that the LAP activity may vary under the influence of several factors within the limits of the genetic control.

Leukocyte Alkaline Phosphatase Isoenzymes in Down’s Syndrome

Enzyme ◽  
1971 ◽  
Vol 12 (3) ◽  
pp. 340-354 ◽  
Author(s):  
W. Tangheroni ◽  
A. Cao ◽  
G. Coppa ◽  
S. Lungarotti ◽  
S. De Virgiliis ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Leukocyte Alkaline Phosphatase ◽  
Alkaline Phosphatase Isoenzymes
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