scholarly journals The substantia nigra and ventral tegmental area in Alzheimer's disease and Down's syndrome.

1989 ◽  
Vol 52 (2) ◽  
pp. 193-200 ◽  
Author(s):  
W R Gibb ◽  
C Q Mountjoy ◽  
D M Mann ◽  
A J Lees
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Ventral Tegmental

scholarly journals Detection of Lewy Bodies in Trisomy 21 (Down's Syndrome)

1993 ◽  
Vol 20 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Ravi Raghavan ◽  
Clare Khin-Nu ◽  
Andrew Brown ◽  
Dorothy Irving ◽  
Paul G. Ince ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Trisomy 21 ◽  
Down's Syndrome ◽  
Lewy Bodies ◽  
Down’S Syndrome ◽  
Alzheimer Type

ABSTRACT:The presence of cortical senile plaques and neurofibrillary tangles sufficient to warrant a neuropatho-logical diagnosis of Alzheimer's disease is well established in middle-aged individuals with Trisomy 21 (Down's syndrome). In contrast a relationship between Down's syndrome and Lewy bodies, one of the major neuropathological features of Parkinson's disease, has not been previously reported. In a cliniconeuropathological survey of 23 cases of Down's Syndrome, two patients, aged 50 and 56 years respectively, were found to have Lewy body formation in the substantia nigra in addition to cortical Alzheimer-type pathology. Neither case showed significant substantia nigra neuron loss although locus coeruleus loss was present in both. Since substantia nigra Lewy bodies are a characteristic neu-rohistological feature of idiopathic Parkinson's disease, their occurrence in cases of Down's syndrome with evidence of Alzheimer-type pathology supports an aetiopathological connection between Parkinson's disease, Alzheimer's disease, and Down's syndrome; and suggests that common pathogenic mechanisms may underlie aspects of neuronal degeneration in these three disorders, some of which may relate to aberrant chromosome 21 expression.

scholarly journals Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains

2021 ◽  
Vol 754 ◽  
pp. 135894
Author(s):  
Eleni Gkanatsiou ◽  
Charlotte Sahlin ◽  
Erik Portelius ◽  
Malin Johannesson ◽  
Linda Söderberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Eleni Gkanatsiou ◽  
Charlotte Sahlin ◽  
Erik Portelius ◽  
Malin Johannesson ◽  
Linda Söderberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down's Syndrome ◽  
Down’S Syndrome

Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with down's syndrome

1993 ◽  
Vol 14 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Angelika Grossmann ◽  
Walter A. Kukull ◽  
John C. Jinneman ◽  
Thomas D. Bird ◽  
Enrique C. Villacres ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intracellular Calcium ◽  
Older Persons ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Calcium Response ◽  
Cd4 Lymphocytes

Neuronal RNA Oxidation in Alzheimer's Disease and Down's Syndrome

1999 ◽  
Vol 893 (1 OXIDATIVE/ENE) ◽  
pp. 362-364 ◽  
Author(s):  
AKIHIKO NUNOMURA ◽  
GEORGE PERRY ◽  
KEISUKE HIRAI ◽  
GJUMRAKCH ALIEV ◽  
ATSUSHI TAKEDA ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Rna Oxidation
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