scholarly journals Abnormal verbal event related potentials in mild cognitive impairment and incipient Alzheimer's disease

2002 ◽  
Vol 73 (4) ◽  
pp. 377-384 ◽  
Author(s):  
J M Olichney
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Event Related Potentials ◽  
Related Potentials

scholarly journals A Systematic Review of Cognitive Event-Related Potentials in mild cognitive impairment and Alzheimer’s disease

2020 ◽  
Author(s):  
Elizabeth R. Paitel ◽  
Marielle R. Samii ◽  
Kristy A Nielson
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Cognitive Processing ◽  
Event Related Potentials ◽  
Complex Tasks ◽  
Related Potentials

This systematic review examined whether event-related potentials (ERPs) during higher cognitive processing can detect subtle, early signs of neurodegenerative disease. Original, empirical studies retrieved from PsycINFO and PubMed were reviewed if they analyzed patterns in cognitive ERPs (150ms post-stimulus) differentiating mild cognitive impairment (MCI), Alzheimer’s disease (AD), or cognitively intact elders who carry AD risk through the Apolipoprotein-E ε4 allele (ε4+) from healthy older adult controls (HC). The 100 studies meeting inclusion criteria (MCI=47; AD=47; ε4+=6) analyzed N200, P300, N400, and occasionally, later components. While there was variability across studies, patterns of reduced amplitude and delayed latency were apparent in pathological aging, consistent with AD-related brain atrophy and cognitive impairment. These effects were particularly evident in advanced disease progression (i.e., AD > MCI) and in later ERP components measured during complex tasks. Although ERP studies in intact ε4+ elders are thus far scarce, a similar pattern of delayed latency was notable, along with a contrasting pattern of increased amplitude, consistent with compensatory neural activation. This limited work suggests ERPs might be able to index early neural changes indicative of future cognitive decline in otherwise healthy elders. As ERPs are also accessible and affordable relative to other neuroimaging methods, their addition to cognitive assessment might substantively enhance early identification and characterization of neural dysfunction, allowing opportunity for earlier differential diagnosis and targeting of intervention. To evaluate this possibility there is urgent need for well-powered studies assessing late cognitive ERPs during complex tasks, particularly in healthy elders at risk for cognitive decline.

Non-attended auditory event-related potentials in mild cognitive impairment and Alzheimer's disease

2012 ◽  
Vol 42 (1-2) ◽  
pp. 70-71
Author(s):  
S. Liljander ◽  
J.V. Partanen ◽  
K. Palmu ◽  
M. Pitkonen ◽  
P. Keski-Säntti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Event Related Potentials ◽  
Auditory Event ◽  
Related Potentials ◽  
Auditory Event Related Potentials

Visual Event-Related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review

2018 ◽  
Vol 16 (1) ◽  
pp. 67-89 ◽  
Author(s):  
Cassandra Morrison ◽  
Sheida Rabipour ◽  
Vanessa Taler ◽  
Christine Sheppard ◽  
Frank Knoefel
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Judgment ◽  
Healthy Aging ◽  
Event Related Potentials ◽  
Healthy Older Adults ◽  
Related Potentials

Background: Cognitive deficits are correlated with increasing age and become more pronounced for people with mild cognitive impairment (MCI) and dementia caused by Alzheimer’s disease (AD). Conventional methods to diagnose cognitive decline (i.e., neuropsychological testing and clinical judgment) can lead to false positives. Tools such as electroencephalography (EEG) offer more refined, objective measures that index electrophysiological changes associated with healthy aging, MCI, and AD. Objective: We sought to review the EEG literature to determine whether visual event-related potentials (ERPs) can distinguish between healthy aging, MCI, and AD. Method: We searched Medline and PyscInfo for articles published between January 2005 and April 2018. Articles were considered for review if they included participants aged 60+ who were healthy older adults or people with MCI and AD, and examined at least one visually elicited ERP component. Results: Our search revealed 880 records, of which 34 satisfied the inclusion criteria. All studies compared cognitive function between at least two of the three groups (healthy older adults, MCI, and AD). The most consistent findings related to the P100 and the P3b; while the P100 showed no differences between groups, the P3b showed declines in amplitude in MCI and AD. Conclusion: Visually elicited ERPs can offer insight into the cognitive processes that decline in MCI and AD. The P3b may be useful in identifying older adults who may develop MCI and AD, and more research should examine the sensitivity and specificity of this component when diagnosing MCI and AD.

Auditory Event-related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease

2018 ◽  
Vol 15 (8) ◽  
pp. 702-715 ◽  
Author(s):  
Cassandra Morrison ◽  
Sheida Rabipour ◽  
Frank Knoefel ◽  
Christine Sheppard ◽  
Vanessa Taler
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Aging ◽  
Event Related Potentials ◽  
Cognitive Changes ◽  
Auditory Event ◽  
Related Potentials ◽  
Auditory Event Related Potentials

Background: Mild cognitive deficits are more likely to occur with increasing age, and become more pronounced for people diagnosed with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Conventional methods to identify cognitive declines (i.e., neuropsychological testing and clinical judgment) can lead to false positive diagnoses of cognitive impairment. Tools such as electroencephalography (EEG) offer additional measures of cognitive processing, indexing the electrophysiological changes associated with aging, MCI and AD. Objective: We reviewed the literature on EEG to determine if auditory event-related potentials (ERPs) could distinguish between healthy aging, MCI, and AD. Method: We searched two electronic databases (Medline and PyscInfo) for articles published between January 2005 and April 2017. Articles were considered for review if they included: i) participants 60 years of age or older; ii) healthy older adults or those diagnosed with MCI or AD; iii) at least one auditory elicited ERP component. Results: Our search revealed 1532 articles (800 after removing duplicates); 719 were excluded through title/abstract review, and of the 81 remaining articles, 30 satisfied inclusion criteria. All studies compared cognitive function between at least two of the three selected populations. Our findings suggest that the P300 and N200 components may distinguish between healthy cognitive aging, MCI, and AD. Conclusion: ERPs may be sensitive to progressive cognitive changes due to MCI and AD. The P300 and N200 may help identify patients who are likely to progress from MCI to AD, and could be a valuable clinical tool.

scholarly journals An Examination of Pain Perception and Cerebral Event-Related Potentials following Carbon Dioxide Laser Stimulation in Patients with Alzheimer’s Disease and Age-Matched Control Volunteers

2001 ◽  
Vol 6 (3) ◽  
pp. 126-132 ◽  
Author(s):  
Stephen J Gibson ◽  
Xenophon Voukelatos ◽  
David Ames ◽  
Leon Flicker ◽  
Robert D Helme
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Carbon Dioxide Laser ◽  
Pain Threshold ◽  
Pain Perception ◽  
Event Related Potentials ◽  
Subjective Rating ◽  
Related Potentials ◽  
Cerebral Event

BACKGROUND: Pain perception is known to depend on integrated cognitive processing. Alzheimer's disease affects 5% to 10% of older adults, but the impact of this disease on pain sensitivity and report has yet to be fully investigated.AIM OF INVESTIGATION: The present study examined pain threshold, the reliability of pain report and the central nervous system processing of noxious input, as indexed by cerebral event-related potentials (CERP).METHODS: Carbon dioxide laser detection and heat pain thresholds were determined on the hand dorsum of 15 healthy older adults (Mini-Mental State Examination [MMSE] score 29.9±0.3) and 15 persons with cognitive impairment (MMSE score 12.7±6.1). Using an array of 15 silver/silver chloride scalp electrodes, the CERP and subjective rating of stimulus intensity were recorded after fixed intensity, 25 W laser stimuli.RESULTS: Compared with age-matched controls, the detection threshold for just noticeable sensation was significantly increased in elderly adults suffering from Alzheimer's disease. There was no difference in pain threshold intensity between persons with cognitive impairment and controls, although the former group was less reliable in reporting detection and pain threshold sensations. The subjective rating of a 25 W stimulus was virtually identical in both groups, and the amplitude of the major CERP component (P400) was similar; however, cognitively impaired adults exhibited a significant increase in the latency of the P400 response.CONCLUSION: The present findings indicate that pain perception in response to an acute heat pain stimulus is not diminished in older persons with cognitive impairment. Patients with Alzheimer's disease may be slightly less reliable in threshold pain report, although the subjective rating of evoked pain and the level of poststimulus cortical activation following noxious stimulation were found to be similar to those of controls. A longer latency of the CERP may suggest slower cortical processing of nociceptive input by persons with Alzheimer's disease.

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