Aneurysm pressure measurement before and after placement of a Pipeline stent: feasibility study using a 0.014 inch pressure wire for coronary intervention

2014 ◽  
Vol 8 (6) ◽  
pp. 603-607 ◽  
Author(s):  
Satoshi Tateshima ◽  
Jesse G Jones ◽  
Fernando Mayor Basto ◽  
Fernando Vinuela ◽  
Gary R Duckwiler
Keyword(s):  
Stent Placement ◽  
Pressure Measurement ◽  
Aneurysm Rupture ◽  
Flow Diversion ◽  
Parent Artery ◽  
Stent Deployment ◽  
Early Results ◽  
Pressure Wire ◽  
Significant Difference ◽  
Before And After

Flow-diverting stents have provided a new endovascular capacity to reconstruct an intracranial aneurysm with its diseased parent artery. The results of first-generation flow diversion stents have been encouraging, with even large or giant treated aneurysms achieving complete angiographic occlusion at 12-month follow-up. Numerous clinical reports have described a slow progressive thrombosis pattern and gradual increase in rate of complete aneurysm obliteration over time. Despite promising early results, some complications specific to flow-diverting stents have been encountered. Chief among them is delayed aneurysm rupture. This complication did not emerge with stent-assisted coil embolization of intracranial aneurysms, and the underlying cause has not been established. However, new evidence suggests that persistent, or even increased, aneurysm pressure after stent placement may play a role in some delayed ruptures. We sought to evaluate this phenomenon by measuring intrasaccular pressure before and after stent placement using two different 0.014 inch coronary pressure measurement wires. Two patients with giant internal carotid artery aneurysms treated with flow-diverting stents were evaluated. Before and after stent deployment, intrasaccular aneurysm and systemic arterial pressures were recorded for 60 s and compared. In both cases, intrasaccular pressure measurement with the use of 0.014 inch pressure wire system was feasible; the pressure wires could be pushed out of the microcatheter placed in the aneurysms without friction or unexpected microcatheter motion. Despite successful flow-diverting stent deployment and angiographic flow diversion effects with excellent wall opposition across the aneurysm necks, there was no significant difference between intrasaccular and systemic pressures.

scholarly journals Comparison of intra-aneurysmal flow modification using optical flow imaging to evaluate the performance of Evolve and Pipeline flow diverting stents

2020 ◽  
Vol 12 (8) ◽  
pp. 814-817 ◽  
Author(s):  
Nicole Mariantonia Cancelliere ◽  
Patrick Nicholson ◽  
Ivan Radovanovic ◽  
Karla Mirella Mendes ◽  
Emanuele Orru ◽  
...  
Keyword(s):  
Optical Flow ◽  
Stent Placement ◽  
Flow Analysis ◽  
Flow Diversion ◽  
Patient Specific ◽  
Stent Deployment ◽  
Flow Modification ◽  
Before And After ◽  
Carotid Aneurysms

BackgroundFlow diverting stent (FDS) devices have revolutionized the treatment of large and complex brain aneurysms, but there is still room for improvement, particularly on the flow diversion properties and technical challenges associated with stent deployment. In this study we compared flow diversion properties between the new generation Surpass Evolve (Stryker) and the Pipeline Flex (Medtronic) devices by quantitatively evaluating intra-aneurysmal flow modification.MethodsAn in vitro experimental set-up was used, consisting of four patient-specific silicone models with internal carotid aneurysms and a circulating hemodynamic simulation system with pulsatile flow. The Evolve and Pipeline stents were deployed across the neck of each aneurysm model, in a randomized fashion, for a total of eight device deployments. A 60 frames/s digital subtraction angiography run was acquired before and after placement of each FDS. An optical flow-analysis method was used to measure intra-aneurysmal flow modification induced by the stent by calculating a mean aneurysm flow amplitude (MAFA) before and after stent placement and computing a ratio.ResultsAverage MAFA ratio values calculated from pre- and post-stent placement were significantly lower after deployment of the Evolve (n=4, mean=0.62±0.09) compared with the Pipeline device (n=4, mean=0.71±0.06) (p=0.03).ConclusionsOur in vitro results show that the Evolve stent had a superior flow diversion effect compared with the Pipeline stent, which—based on clinical evidence—suggest it may promote faster aneurysm occlusion rates in patients.

scholarly journals An autopsy report of basilar artery aneurysm flow diversion complicated by postoperative day 3 hemorrhage from vessel rupture

2018 ◽  
Vol 11 (1) ◽  
pp. e014511 ◽  
Author(s):  
Azeem A Rehman ◽  
Ryan C Turner ◽  
Stephanie Wright ◽  
SoHyun Boo ◽  
Ansaar T Rai
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Basilar Artery ◽  
Artery Aneurysm ◽  
Symptomatic Improvement ◽  
Aneurysm Rupture ◽  
Flow Diversion ◽  
Atheromatous Plaque ◽  
Parent Artery ◽  
Autopsy Report ◽  
Complete Procedure

A middle-aged patient presented with posterior circulation symptoms attributable to a large eccentric basilar trunk aneurysm. The planned treatment was flow diversion with loose coil packing which was successfully performed using a Pipeline Flex device deployed from the basilar to the left posterior cerebral artery. The complete procedure including live biplane fluoroscopy was digitally recorded. The patient had symptomatic improvement postoperatively and was discharged on day 1. The patient suffered a cardiac arrest on postoperative day 3 secondary to massive intraventricular and subarachnoid hemorrhage. An aneurysm rupture was suspected; however, postmortem examination showed an intact aneurysm sac. The hemorrhage was attributed to a small focal rent in the distal basilar artery next to an atheromatous plaque. The Pipeline device was visible through the rent. This is an autopsy report documenting an injury to the parent artery and not the aneurysm as a source of fatal delayed subarachnoid hemorrhage following flow diversion.

scholarly journals Morphologic and Haemodynamic Changes after Stent Placement for Experimental Carotid Aneurysm

2004 ◽  
Vol 10 (1_suppl) ◽  
pp. 153-154 ◽  
Author(s):  
H. Tenjin
Keyword(s):  
Blood Flow ◽  
Digital Subtraction Angiography ◽  
Stent Placement ◽  
Carotid Arteries ◽  
Parent Artery ◽  
Digital Subtraction ◽  
Thin Slices ◽  
Before And After ◽  
Haemodynamic Changes ◽  
Plastic Resin

We investigated and compared the morphologic and haemodynamic changes between before and after stent placement when several different kinds of stents were applied to experimental aneurysms. Experimental aneurysms in eight pig carotid arteries were used. Stents were placed covering the aneurysm orifice. Five Cordis stents (coil stent), two GFXs (multilink stent), and one Multilink (tube stent) were used in this study. After stent placement, the arteries were perfused with 70% ethanol, the specimens were embedded in polyester plastic resin and thin slices were stained with hemtoxilin-eosin. Blood flow in the aneurysm was measured using digital subtraction angiography. The parent artery was stretched in multilink stent (GFX) cases, and was most markedly stretched by use of the tube stent (Multilink). Stent placement with any type of stent decreased intra-aneurysmal blood flow.

Reconstructive endovascular treatment of intracranial aneurysms with the Willis covered stent: medium-term clinical and angiographic follow-up

2011 ◽  
Vol 114 (4) ◽  
pp. 1014-1020 ◽  
Author(s):  
Hua-Qiao Tan ◽  
Ming-Hua Li ◽  
Pei-Lei Zhang ◽  
Yong-Dong Li ◽  
Jian-Bo Wang ◽  
...  
Keyword(s):  
Stent Placement ◽  
Intracranial Aneurysms ◽  
Therapeutic Option ◽  
Covered Stent ◽  
Aneurysm Rupture ◽  
Neurological Deficits ◽  
Parent Artery ◽  
Covered Stents ◽  
Medium Term

Object Placement of covered stents has emerged as a promising therapeutic option for cerebrovascular diseases. However, the medium- and long-term efficacy and safety of covered stents in the treatment of these diseases remain unclear. The purpose of this study was to evaluate the medium-term clinical and angiographic outcomes of covered stent placement for the treatment of intracranial aneurysms. Methods The authors' institutional review board approved the study. Thirty-four patients (13 females and 21 males; mean age 41.9 years) with 38 intracranial aneurysms were treated with the Willis covered stent. Clinical and angiographic follow-up were performed at 3 months, at 6–12 months, and annually thereafter. The initial procedural and follow-up outcomes were collected and analyzed retrospectively. Results Forty-two covered stents were successfully implanted into the target artery in 33 patients with 37 aneurysms, and 1 covered stent navigation failed in 1 patient. A complete aneurysm exclusion was initially achieved in 24 patients with 28 aneurysms, and a minor endoleak occurred in 9 patients with 9 aneurysms. Postoperatively, 2 patients died of complications related to the procedure. Angiographic and clinical follow-up data are available in 30 patients. The angiographic follow-up (17.5 ± 9.4 months [mean ± SD]) exhibited complete occlusion in 28 patients with 31 aneurysms, and incomplete occlusion in 2 aneurysms, with an asymptomatic in-stent stenosis in 3 patients (10%). The clinical follow-up (26.7 ± 13 months [mean ± SD]) demonstrated that 16 patients (53.3%) experienced a full recovery, and 14 patients (46.7%) improved. No aneurysm rupture, thromboembolic events, or neurological deficits resulting from closure of a perforating vessel by covered stent placement occurred. Conclusions Endovascular reconstruction with the Willis covered stent represents a safe, durable, and curative treatment option for selected intracranial aneurysms, yielding an excellent medium-term patency of the parent artery and excellent clinical outcomes.

Distal anterior cerebral artery aneurysms treated with flow diversion: experience of a large-volume center and systematic review of the literature

2020 ◽  
Vol 13 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Federico Cagnazzo ◽  
Andrea Fanti ◽  
Pierre-Henri Lefevre ◽  
Imad Derraz ◽  
Cyril Dargazanli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stent Thrombosis ◽  
Cerebral Artery ◽  
Anterior Cerebral Artery ◽  
Univariate Analysis ◽  
Flow Diversion ◽  
Parent Artery ◽  
Review Of The Literature ◽  
Significant Difference ◽  
Distal Anterior Cerebral Artery

BackgroundEvidence about the safety and the efficacy of flow diversion for distal anterior cerebral artery (DACA) aneurysms is scant. To provide further insight into flow diversion for aneurysms located at, or distal to, the A2 segment.MethodsConsecutive patients receiving flow diversion for DACA aneurysms were retrieved from our prospective database (2014–2020). A PRISMA guidelines-based systematic review of the literature was performed. Aneurysm occlusion (O’Kelly–Marotta=OKM) and clinical outcomes were evaluated.ResultsTwenty-three patients and 25 unruptured saccular DACA aneurysms treated with flow diversion were included. Aneurysm size ranged from 2 mm to 9 mm (mean size 4.5 mm, SD ±1.6). Mean parent artery diameter was 1.8 mm (range, 1.2–3 mm, SD ±0.39). Successful stent deployment was achieved in all cases. Angiographic adequate occlusion (OKM C–D) at follow-up (14 months) was 79% (19/24 available aneurysms). No cases of aneurysm rupture or retreatment were reported. Univariate analysis showed a significant difference in diameter among aneurysms with adequate (4 mm) vs incomplete occlusion (7 mm) (P=0.006).There was one transient perioperative in-stent thrombosis, and three major events causing neurological morbidity: two stent thromboses (one attributable to the non-adherence of the patient to the antiplatelet therapy); and one acute occlusion of a covered calloso-marginal artery.Results from systematic review (12 studies and 107 A2–A3 aneurysms) showed 78.6% (95% CI=70–86) adequate occlusion, 7.5% (95% CI=3.6–14) complications, and 2.8%, (3/107, 95% CI=0.6–8.2) morbidity.ConclusionsFlow diversion among DACA aneurysms is effective, especially among small lesions. However, potential morbidity related to in-stent thrombosis and covered side branches should be considered when planning this strategy.

Contribution of the straightening effect of the parent artery to decreased recanalization in stent-assisted coiling of large aneurysms

2017 ◽  
Vol 127 (5) ◽  
pp. 1063-1069 ◽  
Author(s):  
Akira Ishii ◽  
Hideo Chihara ◽  
Takayuki Kikuchi ◽  
Daisuke Arai ◽  
Hiroyuki Ikeda ◽  
...  
Keyword(s):  
Digital Subtraction Angiography ◽  
Parent Artery ◽  
Digital Subtraction ◽  
Stent Group ◽  
Unruptured Aneurysms ◽  
Angle Change ◽  
Angular Change ◽  
Significant Difference ◽  
Before And After ◽  
The Difference

OBJECTIVEThe durability of embolization of large aneurysms is enhanced by use of the neck-bridging stent. However, it remains unclear what factors contribute to decreased recanalization. The purpose of this study was to demonstrate the contribution of the straightening effect of the parent artery to the durability of stent-assisted coiling for large aneurysms.METHODSOf the 182 aneurysms treated by embolization since the introduction of the neurovascular stent, 82 consecutive unruptured aneurysms with a diameter greater than 7 mm were selected. There were 52 aneurysms treated with a stent (Group S) and 30 treated without a stent (Group NS). Occlusion status was evaluated 12 months after embolization with digital subtraction angiography. The vascular angle of the parent artery was measured before, immediately after, and 12 months after embolization. The rates of recanalization were compared between Group S and Group NS. In Group S, the rates of recanalization were further compared between those aneurysms with and without a significant angle change.RESULTSThe rate of major recanalization was 9.6% in Group S and 26.7% in Group NS. The volume embolization ratio was 32.6% in Group S and 31.6% in Group NS, with no statistically significant difference. However, the angulation change before and after coiling was significantly higher in Group S (10.6°) than in Group NS (0.9°). The difference in the angulation was more evident 12 months after coiling (19.1° in Group S and 1.5° in Group NS). In Group S, recanalization was found in 14.3% of 35 stented aneurysms without a significant angular change when a significant angular change was defined as more than 20°. In contrast, all 17 aneurysms with ≥ 20° of angular change remained occluded.CONCLUSIONSSignificant angular change of ≥ 20° most likely leads to decreased recanalization following stent-assisted embolization of large aneurysms.

scholarly journals SPHINCTEROTOMY ALONE VERSUS SPHINCTEROTOMY AND BILIARY STENT PLACEMENT IN THE TREATMENT OF BILE LEAKS: 10 YEAR EXPERIENCE AT A QUATERNARY HOSPITAL

2021 ◽  
Vol 58 (1) ◽  
pp. 71-76
Author(s):  
Victor K FLUMIGNAN ◽  
Amit H SACHDEV ◽  
João P S NUNES ◽  
Pamela F SILVA ◽  
Lucca H B PIRES ◽  
...  
Keyword(s):  
Stent Placement ◽  
Bile Leak ◽  
Biliary Stent ◽  
Biliary Stenting ◽  
Hepatic Trauma ◽  
Treatment Techniques ◽  
Included Patient ◽  
Significant Difference ◽  
Before And After ◽  
Bile Leaks

ABSTRACT BACKGROUND: Hepatobiliary surgery and hepatic trauma are frequent causes of bile leaks and this feared complication can be safely managed by endoscopic retrograde cholangiopancreatography (ERCP). The approach consists of sphincterotomy alone, biliary stenting or a combination of the two but the optimal form remains unclear. OBJECTIVE: The aim of this study is to compare sphincterotomy alone versus sphincterotomy plus biliary stent placement in the treatment of post-surgical and traumatic bile leaks. METHODS: We retrospectively analyzed 31 patients with the final ERCP diagnosis of “bile leak”. Data collected included patient demographics, etiology of the leak and the procedure details. The treatment techniques were divided into two groups: sphincterotomy alone vs. sphincterotomy plus biliary stenting. We evaluated the volume of the abdominal surgical drain before and after each procedure and the number of days needed until cessation of drainage post ERCP. RESULTS: A total of 31 patients (18 men and 3 women; mean age, 51 years) with bile leaks were evaluated. Laparoscopic cholecystectomy was the etiology of the leak in 14 (45%) cases, followed by conventional cholecystectomy in 9 (29%) patients, hepatic trauma in 5 (16%) patients, and hepatectomy secondary to neoplasia in 3 (9.7%) patients. The most frequent location of the leaks was the cystic duct stump with 12 (38.6%) cases, followed by hepatic common duct in 10 (32%) cases, common bile duct in 7 (22%) cases and the liver bed in 2 (6.5%) cases. 71% of the patients were treated with sphincterotomy plus biliary stenting, and 29% with sphincterotomy alone. There was significant difference between the volume drained before and after both procedures (P<0.05). However, when comparing sphincterotomy alone and sphincterotomy plus biliary stenting, regarding the volume drained and the days needed to cessation of drainage, there was no statistical difference in both cases (P>0.005). CONCLUSION: ERCP remains the first line treatment for bile leaks with no difference between sphincterotomy alone vs sphincterotomy plus stent placement.

scholarly journals An autopsy report of basilar artery aneurysm flow diversion complicated by postoperative day 3 hemorrhage from vessel rupture

2019 ◽  
Vol 11 (5) ◽  
pp. e2-e2
Author(s):  
Azeem A Rehman ◽  
Ryan C Turner ◽  
Stephanie Wright ◽  
SoHyun Boo ◽  
Ansaar T Rai
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Basilar Artery ◽  
Artery Aneurysm ◽  
Symptomatic Improvement ◽  
Aneurysm Rupture ◽  
Flow Diversion ◽  
Atheromatous Plaque ◽  
Parent Artery ◽  
Autopsy Report ◽  
Complete Procedure

A middle-aged patient presented with posterior circulation symptoms attributable to a large eccentric basilar trunk aneurysm. The planned treatment was flow diversion with loose coil packing which was successfully performed using a Pipeline Flex device deployed from the basilar to the left posterior cerebral artery. The complete procedure including live biplane fluoroscopy was digitally recorded. The patient had symptomatic improvement postoperatively and was discharged on day 1. The patient suffered a cardiac arrest on postoperative day 3 secondary to massive intraventricular and subarachnoid hemorrhage. An aneurysm rupture was suspected; however, postmortem examination showed an intact aneurysm sac. The hemorrhage was attributed to a small focal rent in the distal basilar artery next to an atheromatous plaque. The Pipeline device was visible through the rent. This is an autopsy report documenting an injury to the parent artery and not the aneurysm as a source of fatal delayed subarachnoid hemorrhage following flow diversion.

scholarly journals Morphologic and Hemodynamic Changes after Stent Placement for Experimental Carotid Aneurysm

2002 ◽  
Vol 8 (2) ◽  
pp. 143-149 ◽  
Author(s):  
H. Tenjin ◽  
Y. Ohshita ◽  
R. Daimon
Keyword(s):  
Blood Flow ◽  
Stent Placement ◽  
Carotid Arteries ◽  
Parent Artery ◽  
Digital Subtraction ◽  
Hemodynamic Changes ◽  
Thin Slices ◽  
Before And After ◽  
Plastic Resin ◽  
Hematoxylin Eosin

Stent assisted coil embolization is useful in treating broad neck aneurysms, and there are many kinds of stents that can be applied in the cerebral artery, however their characteristics are not well known. We investigated and compared morphologic and hemodynamic changes before and after stent placement when several different kinds of stents were applied to experimental aneurysms. Experimental aneurysms in eight pig carotid arteries were used. Stents were placed covering the aneurysm orifice. Five Cordis stents (coil stent), two GFXs (multilink stent), and one Multilink (tube stent) were used in this study. After coil placement, the arteries were perfused with 70% ethanol, the specimens were embedded in polyester plastic resin and thin slices were stained with hematoxylin-eosin. Blood flow in the aneurysm was measured using digital subtraction angiography. The parent artery was stretched in multilink stent (GFX) cases, and was most markedly stretched by use of the tube stent (Multilink). Stent placement with any type of stent decreased intra-aneurysmal blood flow.

scholarly journals Modification of cerebral vascular anatomy induced by Leo stent placement depending on the site of stenting: A series of 102 cases

2016 ◽  
Vol 22 (6) ◽  
pp. 666-673 ◽  
Author(s):  
Y Chau ◽  
L Mondot ◽  
M Sachet ◽  
J Gaudart ◽  
D Fontaine ◽  
...  
Keyword(s):  
Stent Placement ◽  
Stent Implantation ◽  
Cerebral Circulation ◽  
Vascular Anatomy ◽  
Arterial Segment ◽  
Significant Difference ◽  
Before And After ◽  
The Impact ◽  
Arterial Anatomy ◽  
Cerebral Vascular

Background and purpose Recent studies demonstrated the capacity of stents to modify cerebral vascular anatomy. This study evaluates arterial anatomy deformation after Leo stent placement according to the stenting site and the impact on the immediate postoperative and six-month degree of aneurysmal occlusion. Materials and methods A total of 102 stents were placed against the neck of aneurysms situated in the anterior cerebral circulation. Aneurysms were classified into two groups: The first was called the distal group ( n = 62) and comprised aneurysms situated in the middle cerebral and anterior communicating arteries and the second was called the proximal group ( n = 40) and comprised aneurysms in other sites. The stented arterial segment was classified as deformed or non-deformed by blinded review and superimposition of anonymised films before and after stenting. The degree of occlusion was determined immediately postoperatively and at six months. Results Significantly, anatomical deformity was observed in the distal group compared to the proximal group (85% vs 28%). No significant difference was observed between the two groups in terms of postoperative degree of occlusion. At six months, a significant difference was observed between the two groups: three recurrences in the distal group vs 10 recurrences in the proximal group. Two (3%) recurrences were observed in the deformed group vs 11 (31%) recurrences in the non-deformed group. Conclusions Arterial deformity induced by stenting is even more marked for distal aneurysms. The recurrence rate is smaller when the stent placement results in an arterial anatomical change. The percentage of recurrence is lower when anatomy was amended by stent implantation.

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