Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors

2021 ◽  
pp. neurintsurg-2021-018190
Author(s):  
Stephen R Chen ◽  
Melissa M Chen ◽  
Chibawanye Ene ◽  
Frederick F Lang ◽  
Peter Kan
Keyword(s):  
Brain Tumors ◽  
Targeted Delivery ◽  
Cone Beam Ct ◽  
Therapeutic Agents ◽  
Cone Beam ◽  
Mri Imaging ◽  
Arterial Infusion ◽  
Selective Delivery ◽  
Technological Improvements ◽  
First Time

BackgroundSurvival for glioblastoma remains very poor despite decades of research, with a 5-year survival of only 5%. The technological improvements that have revolutionized treatment of ischemic stroke and brain aneurysms have great potential in providing more precise and selective delivery of cancer therapeutic agents to brain tumors.MethodsWe describe for the first time the use of perfusion guidance to enhance the precision of endovascular super-selective intra-arterial (ESIA) infusions of mesenchymal stem cells loaded with Delta-24 (MSC-D24) in the treatment of glioblastoma (NCT 03896568).ResultsMRI imaging, which best defines the location of the tumor, is co-registered and fused with the patient’s position using cone beam CT, resulting in optimal vessel selection and confirmation of targeted delivery through volumetric perfusion imaging.ConclusionsThis technique of perfusion guided-ESIA injections (PG-ESIA) enhances our ability to perform targeted super-selective delivery of therapeutic agents for brain tumors.

SU-GG-J-60: Daily Cone Beam CT (CBCT) Reduces the Setup Margins Needed for External Beam Radiotherapy of Brain Tumors

2010 ◽  
Vol 37 (6Part10) ◽  
pp. 3159-3159
Author(s):  
N Yu ◽  
S Gajdos ◽  
S Koyfman ◽  
S Chao ◽  
J Suh ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Cone Beam Ct ◽  
External Beam Radiotherapy ◽  
Cone Beam ◽  
External Beam ◽  
Setup Margins

scholarly journals Current Therapeutic Strategies for Glioblastoma

2019 ◽  
Vol 10 (1) ◽  
pp. 15 ◽  
Author(s):  
Julien Rossignol ◽  
Bhairavi Srinageshwar ◽  
Gary L. Dunbar
Keyword(s):  
Stem Cell ◽  
Brain Tumors ◽  
Cell Therapy ◽  
Brain Cancer ◽  
Targeted Delivery ◽  
Therapeutic Agents ◽  
Therapeutic Strategies ◽  
Clinical Settings ◽  
Tumor Site ◽  
Therapeutic Drugs

Glioblastomas (GB) are grade 4 brain tumors, one of the most aggressive forms of brain cancer found in humans. Although current treatments for GB are largely ineffective, new alternate approaches, beyond standard chemo- or radiation therapies have shown promising results in both pre-clinical and clinical settings. Some of these approaches include stem cell therapy, new pharmaceuticals and nutraceuticals, and the use of tumor specific peptides or GB-targeted antibodies and immune-based therapies. A common limitation in the efficacy of these treatments is the inability of these therapeutic agents to readily cross the blood–brain barrier (BBB) to reach the tumor site. Therefore, many strategies are being developed to achieve targeted delivery of drugs across the BBB so that they can kill the cancer cells, while sparing healthy tissue. One of the most promising new approaches involves the use of nanoparticles that can carry therapeutic drugs and genes across the BBB and home in on the GB tumor site.

Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

2020 ◽  
Vol 17 (10) ◽  
pp. 911-924
Author(s):  
Rohitas Deshmukh
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Target Tissue ◽  
Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

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