O35-3 Evidence of a dose-response relationship between work hours and cardiovascular disease risk

2016 ◽  
Author(s):  
Sadie Conway ◽  
Lisa Pompeii ◽  
Robert Roberts ◽  
Jack Follis ◽  
David Gimeno
Keyword(s):  
Cardiovascular Disease ◽  
Dose Response ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Work Hours ◽  
Response Relationship ◽  
Dose Response Relationship

Dose-response Relationship between Exercise and Cardiovascular Disease Risk Factors

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S429
Author(s):  
Noriteru Morita ◽  
Kumiko Igarashi ◽  
Keiji Satake ◽  
Kumiko Fujita ◽  
Naomi Kanazawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Dose Response ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Dose–Response Relation Between Work Hours and Cardiovascular Disease Risk

2016 ◽  
Vol 58 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Sadie H. Conway ◽  
Lisa A. Pompeii ◽  
Robert E. Roberts ◽  
Jack L. Follis ◽  
David Gimeno
Keyword(s):  
Cardiovascular Disease ◽  
Dose Response ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Work Hours

Parity and risk of maternal cardiovascular disease: A dose–response meta-analysis of cohort studies

2018 ◽  
Vol 26 (6) ◽  
pp. 592-602 ◽  
Author(s):  
Wenzhen Li ◽  
Wenyu Ruan ◽  
Zuxun Lu ◽  
Dongming Wang
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Studies ◽  
Dose Response ◽  
Disease Risk ◽  
Meta Analysis ◽  
Cardiovascular Disease Risk ◽  
Response Analysis ◽  
Significant Heterogeneity ◽  
Random Effects Models ◽  
Incident Cases

Background Parity has been reported to play an important role in the development of cardiovascular disease; however, the results are still controversial. We aimed to conduct a meta-analysis of cohort studies to assess quantitatively the association between parity and cardiovascular disease risk. Methods PubMed and Web of Science databases were searched to 1 June 2018, supplemented by manual searches of the bibliographies of retrieved articles. And multivariate-adjusted relative risks were pooled by using random-effects models. Restricted cubic spline analysis with four knots was used to explore the relationship of parity and the risk of cardiovascular disease. Results Ten cohort studies involving 150,512 incident cases of cardiovascular disease among 3,089,929 participants were included in the meta-analysis. A significant association between parity and cardiovascular disease risk was observed while comparing parity with nulliparity, with a summarised relative risk of 1.14 (95% confidence interval (CI) 1.09–1.18; I2 = 62.0%, P = 0.002). In the dose–response analysis, we observed a potential non-linear J-shaped dose–response relationship between the number of parity and cardiovascular disease risk, the summary risk estimates for an increase of one live birth was 1.04 (95% CI 1.02–1.05), with significant heterogeneity ( I2 = 89.6%). In addition, the similar J-shaped associations between parturition number and cardiovascular disease, ischaemic heart disease or stroke risk were also observed. Conclusions Our findings suggest that ever parity is related to cardiovascular disease risk and there is an association between the number of pregnancies and the risk of cardiovascular disease. Since the number of included studies was limited, further studies are warranted to confirm our findings.

Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: how much training for what benefit?

2003 ◽  
Vol 95 (4) ◽  
pp. 1575-1583 ◽  
Author(s):  
Ken-ichi Iwasaki ◽  
Rong Zhang ◽  
Julie H. Zuckerman ◽  
Benjamin D. Levine
Keyword(s):  
Cardiovascular Disease ◽  
Exercise Training ◽  
Endurance Training ◽  
Dose Response ◽  
Function Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Cardiovascular Variability ◽  
Transfer Function Analysis ◽  
Intense Training

Occupational or recreational exercise reduces mortality from cardiovascular disease. The potential mechanisms for this reduction may include changes in blood pressure (BP) and autonomic control of the circulation. Therefore, we conducted the present long-term longitudinal study to quantify the dose-response relationship between the volume and intensity of exercise training, and regulation of heart rate (HR) and BP. We measured steady-state hemodynamics and analyzed dynamic cardiovascular regulation by spectral and transfer function analysis of cardiovascular variability in 11 initially sedentary subjects during 1 yr of progressive endurance training sufficient to allow them to complete a marathon. From this, we found that 1) moderate exercise training for 3 mo decreased BP, HR, and total peripheral resistance, and increased cardiovascular variability and arterial baroreflex sensitivity; 2) more prolonged and intense training did not augment these changes further; and 3) most of these changes returned to control values at 12 mo despite markedly increased training duration and intensity equivalent to that routinely observed in competitive athletes. In conclusion, increases in R-wave-R-wave interval and cardiovascular variability indexes are consistent with an augmentation of vagal modulation of HR after exercise training. It appears that moderate doses of training for 3 mo are sufficient to achieve this response as well as a modest hypotensive effect from decreasing vascular resistance. However, more prolonged and intense training does not necessarily lead to greater enhancement of circulatory control and, therefore, may not provide an added protective benefit via autonomic mechanisms against death by cardiovascular disease.

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