scholarly journals ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e001008 ◽  
Author(s):  
Ho Yin Chung ◽  
Eva Tsz Fung Chui ◽  
Kam Ho Lee ◽  
Helen Hoi Lun Tsang ◽  
Shirley Chiu Wai Chan ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Assessment Tool ◽  
Axial Spondyloarthritis ◽  
Disease Assessment ◽  
Inflammatory Lesions ◽  
Independent Variables ◽  
Apparent Diffusion ◽  
Spine Mri ◽  
Spinal Inflammation

ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores.ResultsEighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01).ConclusionASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool.Trial registration numberHKUCTR-2087.

scholarly journals Test–retest repeatability of the apparent diffusion coefficient in sacroiliac joint MRI in patients with axial spondyloarthritis and healthy individuals

2020 ◽  
Vol 9 (3) ◽  
pp. 205846012090601 ◽  
Author(s):  
Jakob M Møller ◽  
Mikkel Østergaard ◽  
Henrik S Thomsen ◽  
Inge J Sørensen ◽  
Ole R Madsen ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Sacroiliac Joint ◽  
Axial Spondyloarthritis ◽  
Healthy Individuals ◽  
Apparent Diffusion

Comparison of apparent diffusion coefficient in spondylarthritis axial active inflammatory lesions and type 1 modic changes

2014 ◽  
Vol 83 (2) ◽  
pp. 366-370 ◽  
Author(s):  
Benjamin Dallaudière ◽  
Raphaël Dautry ◽  
Pierre-Marie Preux ◽  
Anne Perozziello ◽  
Julien Lincot ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Modic Changes ◽  
Inflammatory Lesions ◽  
Apparent Diffusion

scholarly journals Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week

BJR|Open ◽  
2020 ◽  
Vol 2 (1) ◽  
pp. 20200004
Author(s):  
Jakob Møllenbach Møller ◽  
Mikkel Østergaard ◽  
Henrik S Thomsen ◽  
Stine Hangaard ◽  
Inge J Sørensen ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Healthy Volunteers ◽  
Axial Spondyloarthritis ◽  
Intraclass Correlation ◽  
Region Of Interest ◽  
Apparent Diffusion ◽  
Repeatability And Reproducibility ◽  
Weighted Sequences ◽  
Monitoring Treatment

Objectives: The apparent diffusion coefficient (ADC) may be used as a biomarker for diagnosis and/or monitoring treatment response in patients with axial spondyloarthritis (axSpA), but this requires reliable ADC measurements. This study assessed test–retest repeatability and reproducibility of ADC measurements using four different region of interest (ROI) settings. Methods: In this prospective study, the sacroiliac joints (SIJs) of 25 patients with axSpA and 24 age- and sex-matched healthy volunteers were imaged twice at a mean interval of 6.8 days in a 1.5 T scanner using, multishot echoplanar diffusion-weighted sequences. ADCs at four ROI settings were assessed: 5 mm and 10 mm anatomic band-shaped, 15 mm linear, and 40 mm2 circular. Results: Intraclass correlation coefficient (ICC) assessments showed that the interstudy repeatability was good for median ADC (ADCmed) and 95th-percentile ADC (ADC95) measurements in patients with axSpA (0.77–0.83 and 0.75–0.83, respectively), but poor-to-moderate in healthy subjects (0.27–0.55 and 0.13–0.37, respectively). For all ROI settings, intrareader reproducibility was excellent for ADCmed-measurements (ICC:0.85–0.99) and moderate-to-excellent for ADC95 measurements (ICC:0.68–0.96). The 5 mm ROI had the least estimated bias and highest level of agreement on Bland–Altman plots. The interreader reproducibility was moderate (ICC:0.71). The 15 mm linear ROI produced significantly greater ADCmed and ADC95 measurements than all other ROI settings (p < 0.01–0.02), except for the circular ROI ADC95 measurements. Conclusion: ROI settings influence ADC measurements. Interstudy repeatability of SIJ ADC measurements is independent of ROI settings. However, the 5 mm ROI showed the least bias and random error and seems preferable. Advances in knowledge: ADC measurements are affected by ROI settings, and this should be taken into account when assessing ADC maps.

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