scholarly journals P65 Serological response between HIV-positive and negative cohorts treated for early syphilis

2012 ◽  
Vol 88 (Suppl 1) ◽  
pp. A31.3-A32
Author(s):  
R Dhairyawan ◽  
A Almeida ◽  
M Gunathilake ◽  
B Goh
Keyword(s):  
Hiv Positive ◽  
Serological Response ◽  
Early Syphilis

Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses

2021 ◽  
pp. sextrans-2020-054887
Author(s):  
Silvia Achia Nieuwenburg ◽  
Ricardo Jamie Sprenger ◽  
Maarten Franciscus Schim van der Loeff ◽  
Henry John Christiaan de Vries
Keyword(s):  
Hiv Infection ◽  
Controlled Trial ◽  
Clinical Manifestations ◽  
Response To Treatment ◽  
Disease Stage ◽  
Hiv Positive ◽  
Sexual Risk Behaviour ◽  
Serological Response ◽  
History Of ◽  
Hiv Negative

ObjectivesHIV-positive men who have sex with men (MSM) may be at a higher risk of repeat syphilis, have different clinical manifestations and have a different serological response to treatment compared with HIV-negative MSM. The objective of this study was to assess whether HIV-negative and HIV-positive MSM with infectious syphilis (primary, secondary or early latent) differed in history of previous syphilis episodes, disease stage and non-treponemal titre of initial and repeat episodes, and the titre response 6 and 12 months after treatment. Furthermore, determinants associated with an inadequate titre response after treatment were explored.MethodsThis retrospective analysis used data of five longitudinal studies (four cohorts; one randomised controlled trial) conducted at the STI clinic in Amsterdam, the Netherlands. Participants were tested for syphilis and completed questionnaires on sexual risk behaviour every 3–6 months. We included data of participants with ≥1 syphilis diagnosis in 2014–2019. Pearson’s χ² test was used to compare HIV-negative and HIV-positive MSM in occurrence of previous syphilis episodes, disease stage of initial and repeat syphilis episode and non-treponemal titre treatment responses.ResultsWe included 355 participants with total 459 syphilis episodes. HIV-positive MSM were more likely to have a history of previous syphilis episodes compared with HIV-negative MSM (68/90 (75.6%) vs 96/265 (36.2%); p<0.001). Moreover, HIV-positive MSM with repeat syphilis were less often diagnosed with primary syphilis (7/73 (9.6%) vs 36/126 (28.6%)) and more often diagnosed with secondary syphilis (16/73 (21.9%) vs 17/126 (13.5%)) and early latent syphilis (50/73 (68.5%) vs 73/126 (57.9%)) (p=0.005). While not significantly different at 12 months, HIV-negative MSM were more likely to have an adequate titre response after 6 months compared with HIV-positive MSM (138/143 (96.5%) vs 66/74 (89.2%); p=0.032).ConclusionsIn repeat syphilis, HIV infection is associated with advanced syphilis stages and with higher non-treponemal titres. HIV infection affects the serological outcome after treatment, as an adequate titre response was observed earlier in HIV-negative MSM.

Association of interleukin-10 promoter polymorphisms with serofast state after syphilis treatment

2018 ◽  
Vol 95 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Maciej Pastuszczak ◽  
Bogdan Jakiela ◽  
Anna Wojas-Pelc
Keyword(s):  
Immune Response ◽  
Interleukin 10 ◽  
Control Group ◽  
Serological Response ◽  
Promoter Polymorphisms ◽  
Related Factors ◽  
Adequate Treatment ◽  
Early Syphilis ◽  
Inflammatory Immune Response ◽  
Anti Inflammatory

ObjectivesRecent studies suggested that upregulation of anti-inflammatory immune response during early syphilis may be associated with persistence of Treponema pallidum infection despite adequate treatment, resulting in a serofast state. The objective of this study was to determine whether enhanced interleukin (IL)-10-related response during early T. pallidum infection increased the risk of serofast syphilis.MethodsTwo IL10 gene promoter polymorphisms affecting IL-10 production (−1082A>G [rs1800896], −592C>A [rs1800872]) and serum levels of IL-10 were measured in 80 patients with early syphilis before and 6 months after penicillin treatment and in 24 healthy volunteers (control group).ResultsAfter 6 months, patients were stratified based on serological response into two groups: (1) serofast state (n = 28) and (2) serologically cured (n = 52). Pretreatment and post-treatment serum IL-10 levels were significantly higher in patients who remained serofast compared with those who had a serological cure (p<0.001). The GG genotype of the −1082A>G (rs1800896) polymorphism and the CC genotype of the −592C>A (rs1800872) polymorphism were significantly correlated with higher serum IL-10 levels. Moreover, the OR for remaining serofast for carriers of these genotypes was 16.2 (95% CI: 4.1 to 65.0, p<0.0001) and 2.9 (95% CI: 1.4 to 5.9, p=0.002), respectively.ConclusionsWe showed that a pronounced anti-inflammatory immune response may be an important predictor for the serofast state. Additionally, host-related factors such as polymorphisms of immune regulatory genes may influence the risk of remaining serofast after syphilis therapy.

Clinical factors associated with syphilis concordance in men in sexual partnerships: a cross-sectional couples study

2017 ◽  
Vol 94 (8) ◽  
pp. 571-573 ◽  
Author(s):  
Janet M Towns ◽  
Sarah Huffam ◽  
Eric P F Chow ◽  
Ian Denham ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Health Centre ◽  
Secondary Syphilis ◽  
Sexual Partners ◽  
Concordance Rate ◽  
Hiv Positive ◽  
Clinical Factors ◽  
Syphilis Infection ◽  
Factors Associated ◽  
Early Syphilis ◽  
Male Sexual Partners

BackgroundSyphilis infections continue to increase among men who have sex with men (MSM) in many countries, with rates often higher among HIV-positive MSM. There is limited understanding of the risk and determinants of syphilis transmission between men. We aimed to examine the concordance of early syphilis infection between male sexual partners and clinical factors associated with transmission.MethodsMen attending Melbourne Sexual Health Centre with their male partners, where at least one was diagnosed with early syphilis, were identified from linkage of partner records between March 2011 and April 2016. Early latent syphilis was defined as a new asymptomatic syphilis presentation of less than 2 years’ duration. Associations between concordance and potential risk factors were examined using Fisher’s exact test.ResultsAmong 43 couples (86 men) identified, there were 13 couples (26 men) where both were diagnosed with early syphilis, representing a concordance rate of 30.2% (95% CI 17.2% to 46.1%). Among the 13 concordant couples, 5 men had primary syphilis (4 penile, 1 anal), 11 secondary syphilis (8 generalised rash, 3 penile, 2 anal, 1 oral lesion) and 10 early latent infections. Concordance was higher among couples where at least one partner had secondary syphilis compared with couples where neither partner had secondary syphilis (53% (9/17) vs 15% (4/26), P=0.016). Furthermore, concordance was higher among couples where one was HIV positive compared with couples where both were HIV negative (62% (5/8) vs 23% (8/35), P=0.042).ConclusionsThere was an overall concordance rate of 30%. Higher concordance rates for early syphilis infection between male sexual partners were associated with HIV and secondary syphilis.

Endemic Early Syphilis among Young Newly Diagnosed HIV-Positive Men in a Southeastern U.S. State

2008 ◽  
Vol 22 (12) ◽  
pp. 955-963 ◽  
Author(s):  
Arlene C. Seña ◽  
Elizabeth A. Torrone ◽  
Peter A. Leone ◽  
Evelyn Foust ◽  
Lisa Hightow-Weidman
Keyword(s):  
Hiv Positive ◽  
Newly Diagnosed ◽  
Early Syphilis ◽  
Hiv Positive Men

scholarly journals Similar serological response to conventional therapy for syphilis among HIV-positive and HIV-negative women.

1995 ◽  
Vol 71 (5) ◽  
pp. 275-279 ◽  
Author(s):  
J Goeman ◽  
M Kivuvu ◽  
N Nzila ◽  
F Behets ◽  
B Edidi ◽  
...  
Keyword(s):  
Conventional Therapy ◽  
Hiv Positive ◽  
Serological Response ◽  
Hiv Negative

scholarly journals Early syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin

2014 ◽  
Vol 8 (02) ◽  
pp. 228-232 ◽  
Author(s):  
Jun Li ◽  
He-Yi Zheng
Keyword(s):  
Success Rate ◽  
Serological Test ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Response To Treatment ◽  
Penicillin G ◽  
Serological Response ◽  
Benzathine Penicillin ◽  
College Hospital ◽  
Early Syphilis

Introduction: Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with benzathine penicillin compared with doxycycline or tetracycline. Methodology: We examined rapid plasma regain (RPR) serological test results of all first-time early syphilis patients in Peking Union Medical College Hospital between 2000 and 2011, comparing treatment with two doses of penicillin to 14-day course of oral doxycycline (100 mg twice daily) or oral tetracycline (500 mg 4 times a day). Results: Of the 641 early syphilis cases with available treatment outcome data, 606 (94.5%) received penicillin and 35 (5.5%) received doxycycline/tetracycline. More than half (52.1%) had secondary syphilis, 13.4% had primary syphilis, and 34.5% had early latent syphilis. A statistically similar serological treatment success rate (p = 0.157) was observed in penicillin-treated patients 91.4% (554/606), when compared with patients treated with doxycycline/tetracycline 82.9% (29/35). Conclusion: Doxycycline/tetracycline had a similar serological treatment success rate when compared to penicillin in the treatment of early syphilis.

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