P183 Chronic cough – efficacy of acid suppression therapy in asymptomatic gastroesophageal reflux

2021 ◽  
Author(s):  
H Iftikhar ◽  
B Stoneham ◽  
J Archer ◽  
A Usher
Keyword(s):  
Gastroesophageal Reflux ◽  
Chronic Cough ◽  
Acid Suppression ◽  
Acid Suppression Therapy

scholarly journals Effect of acid suppression therapy on gastroesophageal reflux and cough in idiopathic pulmonary fibrosis: an intervention study

Cough ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. 4 ◽  
Author(s):  
Claire E Kilduff ◽  
Melanie J Counter ◽  
Gareth A Thomas ◽  
Nicholas K Harrison ◽  
Benjamin D Hope-Gill
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Gastroesophageal Reflux ◽  
Intervention Study ◽  
Acid Suppression ◽  
Acid Suppression Therapy

scholarly journals Infantile Gastroesophageal Reflux: Adherence to Treatment Guidelines in the Hospital Setting

2018 ◽  
Vol 23 (1) ◽  
pp. 41-47
Author(s):  
Heather A. Long ◽  
Lauren Solski ◽  
Jill A. Rebuck ◽  
Colin Bridgeman
Keyword(s):  
Gastroesophageal Reflux ◽  
Hospital Setting ◽  
Primary Objective ◽  
Comfort Level ◽  
Acid Suppression ◽  
Institutional Setting ◽  
Inpatient Setting ◽  
Current Guideline ◽  
Pediatric Gastroenterology ◽  
Acid Suppression Therapy

OBJECTIVES Recent guidelines defined and differentiated the management of gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD). The guidelines recommend against using empiric acid suppression therapy for infantile GER. The primary objective of this study was to assess inpatient guideline adherence regarding management of infantile GER through the perspective of pharmacists. Secondary objectives included assessing pharmacist comfort level with differentiation between GER and GERD, observing current trends in practice relating to the primary objective, and determining the availability of institution-specific guidelines that address the management of infantile GER. METHODS An institutional review board-approved, national, online survey of pharmacists with inpatient pediatric experience was conducted. Pediatric pharmacy membership directories were used to create the listserv of eligible pharmacists. The 2009 NASPGHAN/ESPGHAN (North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Gastroenterology, Hepatology, and Nutrition) Pediatric Gastroesophageal Reflux Clinical Practice Guideline was used to develop the survey and to define both GER and GERD. Demographic data was also collected regarding the institutional setting and pharmacists responding. RESULTS The overall response rate was 14.8% (n = 149). Although 29.7% of pharmacists stated empiric acid suppression trials were not used for infantile GER at their institution, 44.6% responded that these trials are initiated 1 to 2 times per week in their hospitals. In addition, 19.6% responded that these empiric trials were initiated 3 to 5 times per week. A smaller percentage of responders reported even higher frequencies per week at their institutions. CONCLUSIONS From the results of the survey, infants continue to receive empiric acid suppression trials for GER in the inpatient setting, which is not adherent to the current guideline recommendation.

scholarly journals P12 The Usefulness Of Heartburn As A Marker Of The Success Of Acid Suppression Therapy In Chronic Cough

Thorax ◽  
2014 ◽  
Vol 69 (Suppl 2) ◽  
pp. A82-A83 ◽  
Author(s):  
H. Badri ◽  
I. Satia ◽  
A. Woodcock ◽  
J. Smith
Keyword(s):  
Chronic Cough ◽  
Acid Suppression ◽  
Acid Suppression Therapy

Silent Gastroesophageal Reflux and Asthma: The Value of Empiric Acid Suppression Therapy

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 705S
Author(s):  
Christopher Canale ◽  
David Young ◽  
Emily Koelliker ◽  
Wayne M. Samuelson ◽  
Kathryn Peterson
Keyword(s):  
Gastroesophageal Reflux ◽  
Acid Suppression ◽  
Acid Suppression Therapy

scholarly journals Heartburn as a Marker of the Success of Acid Suppression Therapy in Chronic Cough

Lung ◽  
2021 ◽  
Author(s):  
H. Badri ◽  
I. Satia ◽  
V. Bansal ◽  
M. A. Mangi ◽  
A. Tangaroonsanti ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Retrospective Review ◽  
Reflux Disease ◽  
Chronic Cough ◽  
Response Rate ◽  
Binary Logistic Regression ◽  
Acid Suppression ◽  
Response To Treatment ◽  
Acid Suppression Therapy ◽  
Predominantly Female

Abstract Purpose Gastro-oesophageal reflux disease (GORD) is commonly thought to play an important role in chronic cough and patients are often empirically treated with acid suppression therapy. We sought to investigate the response rate to acid suppression treatment in patients with and without heartburn attending two specialist cough clinics. Methods A retrospective review of 558 consecutive patients referred to two specialist cough clinics was performed (UK and USA). Patients who were treated with acid suppression were included and their documented response to treatment was collected. Binary logistic regression was used to ascertain the value of reported heartburn in predicting the response of chronic cough to acid suppression therapy. Results Of 558 consecutive referrals, 238 patients were excluded due to missing data or cough duration of < 8 weeks. The remaining 320 patients were predominantly female (76%), with mean age 61 yrs (± 13) and 96.8% non-smokers, with chronic cough for 36 (18–117) months. Of 72 patients with heartburn, 20 (28%) noted improvement in their cough with acid suppression, whereas of 248 without heartburn, only 35 (14%) responded. Patients reporting heartburn were 2.7 (95% C.I. 1.3–5.6) times more likely to respond to acid suppression therapy (p = 0.007). Conclusion In specialist cough clinics, few patients report a response of their chronic cough to acid suppression therapy. Nonetheless, heartburn is a useful predictor substantially increasing the likelihood of benefit.

scholarly journals Heartburn As a Marker of the Success of Acid Suppression Therapy in Chronic Cough.

2021 ◽  
Author(s):  
Huda Badri ◽  
Imran Satia ◽  
Vikas Bansal ◽  
Muhammad Asif Mangi ◽  
Anupong Tangaroonsanti ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Retrospective Review ◽  
Reflux Disease ◽  
Chronic Cough ◽  
Response Rate ◽  
Binary Logistic Regression ◽  
Acid Suppression ◽  
Response To Treatment ◽  
Acid Suppression Therapy ◽  
Predominantly Female

Abstract Purpose: Gastro-oesophageal reflux disease (GORD) is commonly thought to play an important role in chronic cough and patients are often empirically treated with acid suppression therapy. We sought to investigate the response rate to acid suppression treatment in patients with and without heartburn attending two specialist cough clinics. Methods: A retrospective review of 558 consecutive patients referred to two specialist cough clinics was performed (UK and US). Patients who were treated with acid suppression were included and their documented response to treatment collected. Binary logistic regression was used to ascertain the value of reported heartburn in predicting the response of chronic cough to acid suppression therapy. Results: Of 558 consecutive referrals, 238 patients were excluded due to missing data or cough duration of <8weeks. The remaining 320 patients were predominantly female (76%), mean age 61yrs (±13), 96.8% non-smokers, with chronic cough for 36 (18-117) months. Of 72 patients with heartburn, 20 (28%) noted improvement in their cough with acid suppression, whereas of 248 without heartburn, only 35 (14%) responded. Patients reporting heartburn were 2.7 (95% C.I. 1.3-5.6) times more likely to respond to acid suppression therapy (p=0.007).Conclusion: In specialist cough clinics, few patients report a response of their chronic cough to acid suppression therapy. Nonetheless, heartburn is a useful predictor substantially increasing the likelihood of benefit.

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