scholarly journals Commentary: yet more to see down the bronchial tree?

Thorax ◽  
1996 ◽  
Vol 51 (2) ◽  
pp. 226-227
Author(s):  
M. R. Hetzel
Keyword(s):  



2021 ◽  
Author(s):  
Adam B. Lawson ◽  
Brandon P. Hedrick ◽  
M. Scott Echols ◽  
Emma R. Schachner


Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3463
Author(s):  
Mark Farrugia ◽  
Sung Jun Ma ◽  
Mark Hennon ◽  
Chukwumere Nwogu ◽  
Elisabeth Dexter ◽  
...  

The preferred radiotherapeutic approach for central (CLT) and ultracentral (UCLT) lung tumors is unclear. We assessed the toxicity and outcomes of patients with CLT and UCLT who underwent definitive five-fraction stereotactic body radiation therapy (SBRT). We reviewed the charts of patients with either CLT or UCLT managed with SBRT from June 2010–April 2019. CLT were defined as gross tumor volume (GTV) within 2 cm of either the proximal bronchial tree, trachea, mediastinum, aorta, or spinal cord. UCLT were defined as GTV abutting any of these structures. Propensity score matching was performed for gender, performance status, and history of prior lung cancer. Within this cohort of 83 patients, 43 (51.8%) patients had UCLT. The median patient age was 73.1 years with a median follow up of 29.9 months. The two most common dose fractionation schemes were 5000 cGy (44.6%) and 5500 cGy (42.2%) in five fractions. Multivariate analysis revealed UCLT to be associated with worse overall survival (OS) (HR = 1.9, p = 0.02) but not time to progression (TTP). Using propensity score match pairing, UCLT correlated with reduced non-cancer associated survival (p = 0.049) and OS (p = 0.03), but not TTP. Within the matched cohort, dosimetric study found exceeding a D4cc of 18 Gy to either the proximal bronchus (HR = 3.9, p = 0.007) or trachea (HR = 4.0, p = 0.02) was correlated with worse non-cancer associated survival. In patients undergoing five fraction SBRT, UCLT location was associated with worse non-cancer associated survival and OS, which could be secondary to excessive D4cc dose to the proximal airways.



Nature ◽  
1962 ◽  
Vol 195 (4842) ◽  
pp. 715-716 ◽  
Author(s):  
LYNNE REID ◽  
C. McCARTHY ◽  
JALE DUVENCI ◽  
R. A. GIBBONS
Keyword(s):  


2008 ◽  
Vol 47 (19) ◽  
pp. 1695-1698 ◽  
Author(s):  
Maki Bunno ◽  
Masanori Kawaguchi ◽  
Kunihiro Yamahara ◽  
Chieri Kanda




PEDIATRICS ◽  
1972 ◽  
Vol 49 (4) ◽  
pp. 630-631
Author(s):  
Henry Levison ◽  
Norman Aspin

Many physicians do not accept the hypothesis put forward in Dr. Chadwick's letter but rather they still accept the statement by the Committee on Therapy regarding the treatment of cystic fibrosis. This document states, "the aim of nebulization therapy in cystic fibrosis is to deposit particles of water or water-containing medication in the bronchial tree at the site of the disease process" and further goes on to state "nebulization or aerosol therapy must not be confused with humidification."



Sign in / Sign up

Export Citation Format

Share Document