scholarly journals Effects of nasal CPAP on simulated driving performance in patients with obstructive sleep apnoea

Thorax ◽  
1997 ◽  
Vol 52 (7) ◽  
pp. 648-653 ◽  
Author(s):  
C. F. George ◽  
A. C. Boudreau ◽  
A. Smiley
Thorax ◽  
2006 ◽  
Vol 61 (12) ◽  
pp. 1083-1090 ◽  
Author(s):  
D S Hui ◽  
K W To ◽  
F W Ko ◽  
J P Fok ◽  
M C Chan ◽  
...  

2004 ◽  
Vol 118 (4) ◽  
pp. 270-274 ◽  
Author(s):  
Melanie A. Souter ◽  
Scott Stevenson ◽  
Bryn Sparks ◽  
Chris Drennan

Nasal continuous positive airway pressure (CPAP) is the mainstay of treatment for patients with moderate to severe obstructive sleep apnoea (OSA). However, tolerance and compliance are poor.An audit using the Christchurch Hospital ORL surgery database identified patients who underwent upper airway surgery for OSA. Tracheostomy and bimaxillary advancement patients were excluded. Adults with moderate to severe OSA (Desaturation Index (DI) >10 n.h-1), who had failed atrial of nasal CPAP, and had pre-operative and post-operative sleep study data were identified. Objective (DI) and Subjective (Epworth Sleepiness Score (ESS)) outcome measures were recorded.The database identified 69 patients who underwent surgery for snoring or OSA; of these, 25 patients formed the study group. Sixteen out of 25 improved (64 per cent) after surgery, seven out of 25 showed no change (28 per cent), two patients (eight per cent) showed deterioration in their DI. Forty-eight per cent of patients had >50 per cent post-operative improvement in DI. Fourteen out of 25 (56 per cent) had a post-operative DI <20 n.h-1. Seven out of 25 (28 per cent) had a post-operative DI <10 n.h-1. Upper airway surgery has a role in the managementof selected patients with OSA who cannot tolerate nasal CPAP.


1989 ◽  
Vol 77 (4) ◽  
pp. 407-411 ◽  
Author(s):  
J. Krieger ◽  
L. Laks ◽  
I. Wilcox ◽  
R. R. Grunstein ◽  
L. J. V. Costas ◽  
...  

1. Plasma levels of atrial natriuretic peptide (ANP) were measured in seven patients with obstructive sleep apnoea (OSA) while they were awake, during repetitive apnoea and during treatment with nasal continuous positive airway pressure (CPAP). 2. ANP levels in both pulmonary artery and peripheral venous samples were elevated during apnoeic sleep and reduced when apnoea was prevented by nasal CPAP. Mean values of pulmonary artery ANP were 116.3 ± 17.9 pg/ml during apnoea and 64.8 ± 15.2 pg/ml (P < 0.05) on nasal CPAP. 3. It is concluded that there is increased ANP release during sleep in patients with OSA and that CPAP treatment normalizes ANP secretion. These findings may explain previously identified urinary abnormalities in OSA.


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