Collision tumour of two nodal metastases (adenocarcinoma and mast cell tumour) in a dog

2020 ◽  
Vol 8 (3) ◽  
pp. e001231
Author(s):  
Danielle Gibson ◽  
Samuel Beck ◽  
Esteban Gonzàlez-Gasch ◽  
Aaron Harper
Keyword(s):  
Mast Cell ◽  
Lymph Node ◽  
Neuroendocrine Tumour ◽  
Abdominal Ultrasound ◽  
Cell Tumour ◽  
Iliac Lymph Node ◽  
Mast Cell Tumour ◽  
Collision Tumour ◽  
Anal Sac ◽  
The Right

An 11-year-old female neutered Labrador retriever was referred for a large vulvar mast cell tumour that extended into the vagina. Abdominal ultrasound revealed an enlarged right medial iliac lymph node, and cytology of the node was consistent with an endocrine/neuroendocrine tumour. An approximately 1.5-cm right anal sac mass was palpated. Medial iliac lymphadenectomy via ventral celiotomy, right anal sacculectomy and marginal vulvar mass resection were performed. Histopathology was consistent with right anal sac adenocarcinoma, vulvar mast cell tumour, and the right medial iliac lymph node showed a metastatic collision of both the adenocarcinoma and mast cell tumour cell populations. Adjunctive chemotherapy and radiotherapy were recommended to address the risk of local recurrence and further metastasis but were declined by the owner. The dog remains alive and asymptomatic with no visible evidence of recurrence 14 months after initial presentation.

Cutaneous mast cell tumour within a lipoma in a boxer

2009 ◽  
Vol 57 (2) ◽  
pp. 263-274 ◽  
Author(s):  
Csaba Jakab ◽  
Attila Szász ◽  
Janina Kulka ◽  
Zsuzsa Schaff ◽  
Miklós Rusvai ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Vascular Endothelium ◽  
Immunohistochemical Staining ◽  
Cell Tumour ◽  
Proliferation Index ◽  
Ki 67 ◽  
Mast Cell Tumour ◽  
Cutaneous Mast Cell ◽  
The Right

This report describes a case of a canine cutaneous grade I mast cell tumour which developed within a lipoma in the right axillar region of an 8-year-old male Boxer. Immunohistologically, the neoplastic mast cells were positive for serotonin, CD45 vimentin and p53, and negative for lysozyme, CD3 and CD79a expression. The proliferation index of the mast cell tumour based on the Ki-67 antigen was 6.1%. Between the benign neoplastic lipocytes and mastocytoma tumour cells intratumoural microvessels were detected by immunohistochemical staining using CD31 and claudin-5 as markers for vascular endothelium.

Primary Clitoral Adenocarcinoma With Secondary Hypercalcemia of Malignancy in a Dog

2010 ◽  
Vol 46 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Steven A. Neihaus ◽  
Jennifer E. Winter ◽  
Robert L. Goring ◽  
F. A. Kennedy ◽  
Matti Kiupel
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Abdominal Ultrasound ◽  
Apocrine Gland ◽  
Hypercalcemia Of Malignancy ◽  
Node Metastasis ◽  
Iliac Lymph Node ◽  
Internal Iliac ◽  
Anal Sac ◽  
Anal Sacs

This report describes a primary clitoral adenocarcinoma in a dog with secondary hypercalcemia of malignancy. A 10-year-old, spayed female basset hound was evaluated for a mass protruding from the vulva. The mass was excised, and a histological diagnosis of clitoral adenocarcinoma was made. No evidence of metastasis on thoracic radiographs or abdominal ultrasound was seen. Preoperative hypercalcemia resolved following excision of the mass. Cellular features were similar to an apocrine gland anal sac adenocarcinoma, and immunohistochemistry exhibited features noted with apocrine gland anal sac adenocarcinoma. No further treatment was elected by the owner. Internal iliac lymph-node metastasis was identified 4 weeks postoperatively, and hypercalcemia recurred 8 weeks postoperatively. The dog was euthanized 22 weeks postoperatively for signs related to hypercalcemia, including polyuria/polydipsia, lethargy, and weakness. A necropsy was performed and confirmed the presence of internal iliac lymph-node metastasis. The colon, rectum, and anal sacs were grossly and histologically normal. To our knowledge, this is the first reported case of clitoral neoplasia in the dog.

Combined Z-plasty and phalangeal fillet for reconstruction of a large carpal defect following ablative oncologic sur gery

2013 ◽  
Vol 26 (06) ◽  
pp. 510-514 ◽  
Author(s):  
M. G. Renwick ◽  
D. A. Yool ◽  
M. Cantatore
Keyword(s):  
Mast Cell ◽  
Lymph Node ◽  
Preoperative Staging ◽  
Cell Tumour ◽  
Fine Needle Aspirate ◽  
Mast Cell Tumour ◽  
Dorsal Aspect ◽  
Grade Ii ◽  
Large Wound ◽  
Disease Free

SummaryA six-year-old Labrador Retriever was presented for management of a 2 x 2 cm cutaneous mass over the dorsal aspect of the carpus. A fine needle aspirate performed by the referring veterinarian was consistent with a mast cell tumour. The ipsilateral prescapular lymph node was enlarged. Preoperative staging did not reveal any evidence of metastasis. Wide excision of the mass and prescapular lymphadenectomy were performed. The large carpal wound was reconstructed using a combination of Z-plasty and phalangeal fillet using the first digit (dewclaw); about 20% of the original defect was allowed to heal by second intention. Histopathology was consistent with a grade II mast cell tumour with metastatic spread to the lymph node. Vinblastine and prednisolone adjuvant chemotherapy was instituted. Functional and cosmetic outcome were good; only a small 1cm area of alopecia persisted. The dog was disease-free 53 months after surgery. A combination of Z-plasty and a phalangeal fillet using the first digit was a successful treatment to reconstruct a large wound over the dorsal aspect of the carpus in this case.

redox status evaluation in dogs affected by mast cell tumour

2012 ◽  
Vol 12 (2) ◽  
pp. 120-129 ◽  
Author(s):  
R. Finotello ◽  
A. Pasquini ◽  
V. Meucci ◽  
I. Lippi ◽  
A. Rota ◽  
...  
Keyword(s):  
Mast Cell ◽  
Redox Status ◽  
Cell Tumour ◽  
Mast Cell Tumour

scholarly journals Treatment of a feline cutaneous mast cell tumour using imatinib mesylate as a neoadjuvant tyrosine kinase inhibitor therapeutic agent

2020 ◽  
Vol 65 (No. 2) ◽  
pp. 84-88
Author(s):  
J Kim ◽  
HJ Kim
Keyword(s):  
Mast Cell ◽  
Imatinib Mesylate ◽  
Histopathological Examination ◽  
The Body ◽  
Cell Tumour ◽  
Surgical Removal ◽  
Anatomical Location ◽  
Tumour Mass ◽  
Mast Cell Tumour ◽  
Cutaneous Mast Cell

A two-year-old spayed female American shorthair cat presented with a rough, circular, exophytic mass on the genital area. The clinical findings and histopathological examination revealed that the mass contained neoplastic mast cells and, thus, was diagnosed as a mast cell tumour. The anatomical location of the mass was not easily accessible for surgical intervention. We administered a targeted therapy using oral imatinib mesylate for eight weeks to reduce the size of the lesion and to facilitate the successful surgical removal. The tumour mass eventually reduced by 21% and was surgically excised. This is possibly the first study to use imatinib mesylate as a tumour reduction neoadjuvant to therapeutically address a feline cutaneous mast cell tumour located in a surgically inaccessible part of the body.

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