Reproductive failure associated with porcine parvovirus in an enzootically infected pig herd

1992 ◽  
Vol 131 (22) ◽  
pp. 503-506 ◽  
Author(s):  
C. Huysman ◽  
L. van Leengoed ◽  
M. de Jong ◽  
A. van Osta
Keyword(s):  
Reproductive Failure ◽  
Porcine Parvovirus

scholarly journals Porcine Parvovirus Infection Causes Pig Placenta Tissue Damage Involving Nonstructural Protein 1 (NS1)-Induced Intrinsic ROS/Mitochondria-Mediated Apoptosis

Viruses ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 389 ◽  
Author(s):  
Zhang ◽  
Fan ◽  
Li ◽  
Liang ◽  
Huo ◽  
...  
Keyword(s):  
Host Cell ◽  
Cell Apoptosis ◽  
Nonstructural Protein ◽  
Placental Tissue ◽  
Reproductive Failure ◽  
Porcine Parvovirus ◽  
Nonstructural Protein 1 ◽  
Host Cell Apoptosis ◽  
Tissue Damages ◽  
Induced Apoptosis

Porcine parvovirus (PPV) is an important pathogen causing reproductive failure in pigs. PPV-induced cell apoptosis has been recently identified as being involved in PPV-induced placental tissue damages resulting in reproductive failure. However, the molecular mechanism was not fully elucidated. Here we demonstrate that PPV nonstructural protein 1 (NS1) can induce host cell apoptosis and death, thereby indicating the NS1 may play a crucial role in PPV-induced placental tissue damages and reproductive failure. We have found that NS1-induced apoptosis was significantly inhibited by caspase 9 inhibitor, but not caspase 8 inhibitor, and transfection of NS1 gene into PK-15 cells significantly inhibited mitochondria-associated antiapoptotic molecules Bcl-2 and Mcl-1 expressions and enhanced proapoptotic molecules Bax, P21, and P53 expressions, suggesting that NS1-induced apoptosis is mainly through the mitochondria-mediated intrinsic apoptosis pathway. We also found that both PPV infection and NS1 vector transfection could cause host DNA damage resulting in cell cycle arrest at the G1 and G2 phases, trigger mitochondrial ROS accumulation resulting in mitochondria damage, and therefore, induce the host cell apoptosis. This study provides a molecular basis for elucidating PPV-induced cell apoptosis and reproductive failure.

scholarly journals Genetic Analysis of Porcine Parvoviruses Detected in South Korean Wild Boars

2021 ◽  
Author(s):  
Gyu-Nam Park ◽  
Sok Song ◽  
Ra Mi Cha ◽  
SeEun Choe ◽  
Jihye Shin ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Genetic Characterization ◽  
Reproductive Failure ◽  
Porcine Parvovirus ◽  
Conserved Motifs ◽  
Catalytic Center ◽  
Wild Boars ◽  
South Korean ◽  
Binding Loop

Abstract Porcine parvovirus 1 (PPV1) is a major cause of reproductive failure in pigs; to date, six novel porcine parvoviruses (PPV2–PPV7) have been identified. Here, we detected 11 PPV1, five PPV3, three PPV4, six PPV5, five PPV6, and one PPV7 strain in Korean wild boars. PPV1, -3, and -5, and PPV6, from Korean wild boars harbor conserved motifs within the Ca2+ binding loop and the catalytic center of the PLA1 motif. Intra-recombination among PPV7 strains was also identified. Genetic characterization revealed that PPV1 from Korean wild boars may be similar to virulent PPV strains.

A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure

Vaccine ◽  
2006 ◽  
Vol 24 (26) ◽  
pp. 5481-5490 ◽  
Author(s):  
Adriaan F.G. Antonis ◽  
Christianne J.M. Bruschke ◽  
Paloma Rueda ◽  
Luis Maranga ◽  
J. Ignacio Casal ◽  
...  
Keyword(s):  
Recombinant Virus ◽  
Reproductive Failure ◽  
Porcine Parvovirus ◽  
Virus Like Particle

scholarly journals A Systematic Investigation Unveils High Coinfection Status of Porcine Parvovirus Types 1 through 7 in China from 2016 to 2020

2021 ◽  
Author(s):  
Jixiang Li ◽  
Yanzhao Xiao ◽  
Ming Qiu ◽  
Xinshuai Li ◽  
Shubin Li ◽  
...  
Keyword(s):  
Synergistic Effects ◽  
Systematic Investigation ◽  
Reproductive Failure ◽  
Porcine Parvovirus

Porcine parvoviruses (PPVs) are prevalent in China associating with reproductive failure in swine. The coinfection of seven genotypes of PPVs (PPV1-7) might have synergistic effects on PPV1 associated SMEDI syndrome.

scholarly journals Detection and molecular characterization of porcine parvovirus in fetal tissues from sows without reproductive failure in Argentina

Heliyon ◽  
2019 ◽  
Vol 5 (11) ◽  
pp. e02874 ◽  
Author(s):  
M.S. Serena ◽  
J.A. Cappuccio ◽  
G.E. Metz ◽  
C.G. Aspitia ◽  
M. Dibárbora ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Reproductive Failure ◽  
Porcine Parvovirus ◽  
Fetal Tissues

scholarly journals Porcine Circovirus 3 Detection in Aborted Fetuses and Stillborn Piglets from Swine Reproductive Failure Cases

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 264
Author(s):  
Viviane Saporiti ◽  
Laura Valls ◽  
Jaime Maldonado ◽  
Mónica Perez ◽  
Florencia Correa-Fiz ◽  
...  
Keyword(s):  
High Viral Load ◽  
Reproductive Failure ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Porcine Parvovirus ◽  
Reproductive Disease ◽  
Porcine Circovirus 3 ◽  
Clinical Conditions ◽  
Domestic Swine

Porcine circovirus 3 (PCV-3) has been widely detected in healthy and diseased pigs; among different pathologic conditions, the strongest evidence of association comes from reproductive disease cases. However, simple viral detection does not imply the causality of the clinical conditions. Detection of PCV-3 within lesions may provide stronger evidence of causality. Thus, this study aimed to assess the frequency of PCV-3 detection in tissues from fetuses/stillborn piglets in cases of reproductive problems in domestic swine, as well as the histopathologic assessment of fetal tissues. Fetuses or stillborn piglets from 53 cases of reproductive failure were collected and analyzed by PCV-3 qPCR. The presence of porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus 2 (PCV-2), and porcine parvovirus 1 (PPV1) was also checked. PCV-3 qPCR positive samples with a high viral load were tested by PCV-3 in situ hybridization (ISH), sequenced, and phylogenetically analyzed. PCV-3 DNA was detected in 18/53 (33.9%) reproductive failure cases and in 16 of them PCV-3 was the only pathogen found. PCV-2 DNA was found in 5/53 (9.4%), PRRSV RNA in 4/53 (7.5%) and PPV1 was not detected. Four out of the six PCV-3 qPCR-positive cases with Ct value <30 were positive when tested by ISH. In these samples, PCV-3 was detected within mild histopathologic lesions, such as arteritis and periarteritis in multiple tissues. The present work emphasizes the need to include PCV-3 as a potential causative agent of reproductive failure in swine.

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