A Systematic Investigation Unveils High Coinfection Status of Porcine Parvovirus Types 1 through 7 in China from 2016 to 2020

Microbiology Spectrum ◽

10.1128/spectrum.01294-21 ◽

2021 ◽

Author(s):

Jixiang Li ◽

Yanzhao Xiao ◽

Ming Qiu ◽

Xinshuai Li ◽

Shubin Li ◽

...

Keyword(s):

Synergistic Effects ◽

Systematic Investigation ◽

Reproductive Failure ◽

Porcine Parvovirus

Porcine parvoviruses (PPVs) are prevalent in China associating with reproductive failure in swine. The coinfection of seven genotypes of PPVs (PPV1-7) might have synergistic effects on PPV1 associated SMEDI syndrome.

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Reproductive failure associated with porcine parvovirus in an enzootically infected pig herd

Veterinary Record ◽

10.1136/vr.131.22.503 ◽

1992 ◽

Vol 131 (22) ◽

pp. 503-506 ◽

Cited By ~ 6

Author(s):

C. Huysman ◽

L. van Leengoed ◽

M. de Jong ◽

A. van Osta

Keyword(s):

Reproductive Failure ◽

Porcine Parvovirus

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Porcine Parvovirus Infection Causes Pig Placenta Tissue Damage Involving Nonstructural Protein 1 (NS1)-Induced Intrinsic ROS/Mitochondria-Mediated Apoptosis

Viruses ◽

10.3390/v11040389 ◽

2019 ◽

Vol 11 (4) ◽

pp. 389 ◽

Cited By ~ 6

Author(s):

Zhang ◽

Fan ◽

Li ◽

Liang ◽

Huo ◽

...

Keyword(s):

Host Cell ◽

Cell Apoptosis ◽

Nonstructural Protein ◽

Placental Tissue ◽

Reproductive Failure ◽

Porcine Parvovirus ◽

Nonstructural Protein 1 ◽

Host Cell Apoptosis ◽

Tissue Damages ◽

Induced Apoptosis

Porcine parvovirus (PPV) is an important pathogen causing reproductive failure in pigs. PPV-induced cell apoptosis has been recently identified as being involved in PPV-induced placental tissue damages resulting in reproductive failure. However, the molecular mechanism was not fully elucidated. Here we demonstrate that PPV nonstructural protein 1 (NS1) can induce host cell apoptosis and death, thereby indicating the NS1 may play a crucial role in PPV-induced placental tissue damages and reproductive failure. We have found that NS1-induced apoptosis was significantly inhibited by caspase 9 inhibitor, but not caspase 8 inhibitor, and transfection of NS1 gene into PK-15 cells significantly inhibited mitochondria-associated antiapoptotic molecules Bcl-2 and Mcl-1 expressions and enhanced proapoptotic molecules Bax, P21, and P53 expressions, suggesting that NS1-induced apoptosis is mainly through the mitochondria-mediated intrinsic apoptosis pathway. We also found that both PPV infection and NS1 vector transfection could cause host DNA damage resulting in cell cycle arrest at the G1 and G2 phases, trigger mitochondrial ROS accumulation resulting in mitochondria damage, and therefore, induce the host cell apoptosis. This study provides a molecular basis for elucidating PPV-induced cell apoptosis and reproductive failure.

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Reproductive failure in wild boars associated to porcine parvovirus infection and in vivo and in vitro characterization of the causal isolate

Tropical Animal Health and Production ◽

10.1007/s11250-010-9644-9 ◽

2010 ◽

Vol 42 (8) ◽

pp. 1611-1613 ◽

Cited By ~ 7

Author(s):

Chao-fan Zhang ◽

Cui-Ping Song ◽

Chang-mu Chen ◽

Shang-jin Cui ◽

Lan-fei Miao

Keyword(s):

Reproductive Failure ◽

Porcine Parvovirus ◽

Wild Boars ◽

In Vitro Characterization

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Genetic Analysis of Porcine Parvoviruses Detected in South Korean Wild Boars

10.21203/rs.3.rs-344017/v1 ◽

2021 ◽

Author(s):

Gyu-Nam Park ◽

Sok Song ◽

Ra Mi Cha ◽

SeEun Choe ◽

Jihye Shin ◽

...

Keyword(s):

Genetic Analysis ◽

Genetic Characterization ◽

Reproductive Failure ◽

Porcine Parvovirus ◽

Conserved Motifs ◽

Catalytic Center ◽

Wild Boars ◽

South Korean ◽

Binding Loop

Abstract Porcine parvovirus 1 (PPV1) is a major cause of reproductive failure in pigs; to date, six novel porcine parvoviruses (PPV2–PPV7) have been identified. Here, we detected 11 PPV1, five PPV3, three PPV4, six PPV5, five PPV6, and one PPV7 strain in Korean wild boars. PPV1, -3, and -5, and PPV6, from Korean wild boars harbor conserved motifs within the Ca2+ binding loop and the catalytic center of the PLA1 motif. Intra-recombination among PPV7 strains was also identified. Genetic characterization revealed that PPV1 from Korean wild boars may be similar to virulent PPV strains.

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