scholarly journals Numerical Analysis of a Nonconvex Variational Problem Related to Solid-Solid Phase Transitions

1994 ◽  
Vol 31 (1) ◽  
pp. 111-127 ◽  
Author(s):  
Pierre-Alain Gremaud
2003 ◽  
Vol 2003 (10) ◽  
pp. 535-551
Author(s):  
A. Elfanni

We consider a nonconvex variational problem for which the set of admissible functions consists of all Lipschitz functions located between two fixed obstacles. It turns out that the value of the minimization problem at hand is equal to zero when the obstacles do not touch each other; otherwise, it might be positive. The results are obtained through the construction of suitable minimizing sequences. Interpolating these minimizing sequences in some discrete space, a numerical analysis is then carried out.


Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1014
Author(s):  
Macy L. Sprunger ◽  
Meredith E. Jackrel

Aberrant protein folding underpins many neurodegenerative diseases as well as certain myopathies and cancers. Protein misfolding can be driven by the presence of distinctive prion and prion-like regions within certain proteins. These prion and prion-like regions have also been found to drive liquid-liquid phase separation. Liquid-liquid phase separation is thought to be an important physiological process, but one that is prone to malfunction. Thus, aberrant liquid-to-solid phase transitions may drive protein aggregation and fibrillization, which could give rise to pathological inclusions. Here, we review prions and prion-like proteins, their roles in phase separation and disease, as well as potential therapeutic approaches to counter aberrant phase transitions.


1994 ◽  
Vol 127 (1) ◽  
pp. 41-99 ◽  
Author(s):  
Paolo Cermelli ◽  
Morton E. Gurtin

2018 ◽  
Author(s):  
P. Bowlan ◽  
L. Smilowitz ◽  
B. F. Henson ◽  
N. Suvorova ◽  
D. Oschwald

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