Clarification of the structure of the ampicillin-resistance plasmid RSF0885 from Haemophilus influenzae HR-885 serotype b

1994 ◽  
Vol 40 (2) ◽  
pp. 154-157 ◽  
Author(s):  
W. L. Albritton ◽  
P. A. Noble ◽  
K. D. Webster
Keyword(s):  
Escherichia Coli ◽  
Haemophilus Influenzae ◽  
Sequencing Data ◽  
Original Source ◽  
Ampicillin Resistance ◽  
Resistance Plasmid ◽  
Haemophilus Parainfluenzae ◽  
Serotype B ◽  
Restriction Enzyme Maps

The nonconjugative ampicillin-resistance plasmid RSF0885 has been reported to be as small as 2.9 MDa and as large as 4.1 MDa with at least two restriction enzyme maps reported. In addition, the source of the original plasmid has been reported to be Haemophilus influenzae and Haemophilus parainfluenzae. Characterization of the source strains and sequencing data of the plasmids revealed that H. influenzae serotype b was the original source strain and that ISI-K in the larger plasmid was presumably acquired when the smaller plasmid was maintained in Escherichia coli in S. Falkow's laboratory during the late 1970s.Key words: Haemophilus influenzae, Haemophilus parainfluenzae, RSF0885, ampicillin resistance, ISI-K

scholarly journals Characterization of non-beta-lactamase-mediated ampicillin resistance in Haemophilus influenzae.

1984 ◽  
Vol 26 (2) ◽  
pp. 235-244 ◽  
Author(s):  
P M Mendelman ◽  
D O Chaffin ◽  
T L Stull ◽  
C E Rubens ◽  
K D Mack ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Beta Lactamase ◽  
Ampicillin Resistance

Clinical Characterization of Invasive Disease Caused by Haemophilus influenzae Serotype b in a High Vaccination Coverage Setting

2018 ◽  
Vol 8 (3) ◽  
pp. 261-264
Author(s):  
Susana Monge ◽  
Liesbeth Mollema ◽  
Hester de Melker ◽  
Elisabeth Sanders ◽  
Arie van der Ende ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Haemophilus Influenzae ◽  
Vaccination Coverage ◽  
Invasive Disease ◽  
National Study ◽  
Healthy Children ◽  
Disease Course ◽  
Serotype B

Abstract This national study characterized invasive Haemophilus influenzae serotype b infections. Vaccinated (n = 41) and nonvaccinated (n = 10) cases were similar regarding presentation as meningitis (68.8% vs 90.0%; P = .25), predisposing factors (29.3% vs 20.0%; P = .76), admission to intensive care unit or death (22.0% vs 10.0%; P = 1.00), or sequelae (21.6% vs 10.0%; P = .81). Haemophilus influenzae serotype b occurred in vaccinated, healthy children with comparable disease course.

scholarly journals Site-Specific Recombination with the Chromosomal tRNALeu Gene by the Large Conjugative Haemophilus Resistance Plasmid

2002 ◽  
Vol 46 (5) ◽  
pp. 1602-1603 ◽  
Author(s):  
Ioanna D. Dimopoulou ◽  
Joanne E. Russell ◽  
Zaini Mohd-Zain ◽  
Rebecca Herbert ◽  
Derrick W. Crook
Keyword(s):  
Haemophilus Influenzae ◽  
Site Specific ◽  
Site Specific Recombination ◽  
Resistance Plasmid ◽  
Diverse Origin

ABSTRACT Characterization of the sequences involved in recombination of the Haemophilus plasmid p1056 with the Haemophilus influenzae chromosome produced evidence indicating site-specific recombination with chromosomal tRNALeu. attP sequences identical to those of p1056 were found in six plasmids of diverse origin, suggesting that a family of Haemophilus plasmids recombines with chromosomal tRNALeu.

scholarly journals Molecular Characterization of a 21.4 Kilobase Antibiotic Resistance Plasmid from an α-Hemolytic Escherichia coli O108:H- Human Clinical Isolate

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34718
Author(s):  
Fay E. Dawes ◽  
Dieter M. Bulach ◽  
Alexander Kuzevski ◽  
Karl A. Bettelheim ◽  
Carola Venturini ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Molecular Characterization ◽  
Clinical Isolate ◽  
Resistance Plasmid

scholarly journals Invasive Haemophilus influenzae Infections in Germany After the Introduction of Routine Childhood Immunization, 2001–2016

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Anja Takla ◽  
Viktoria Schönfeld ◽  
Heike Claus ◽  
Manuel Krone ◽  
Matthias an der Heiden ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Disease Surveillance ◽  
Age Groups ◽  
Childhood Immunization ◽  
Comprehensive Overview ◽  
Ampicillin Resistance ◽  
Laboratory Surveillance ◽  
The Mean ◽  
Serotype B ◽  
Increasing Trends

Abstract Background Haemophilus influenzae (Hi) serotype b (Hib) vaccination was introduced in Germany in 1990. This study presents a comprehensive overview on the burden of invasive Hi infections for 2001–2016, including serotype distribution and ampicillin resistance. Methods Nationwide data from statutory disease surveillance (2001–2016) were linked with laboratory surveillance data (2009–2016). Besides descriptive epidemiology, statistical analyses included multiple imputation to estimate secular trends. Results In 2001–2016, 4044 invasive Hi infections were reported. The mean incidence was 3.0 per million inhabitants, higher in males (3.2 vs 2.9 in females) and in the age groups <1 year (15.2) and ≥80 years (15.5). Nontypeable Hi (NTHi) caused 81% (n = 1545) of cases in 2009–2016. Of capsulated cases, 69% were serotype f and 17% serotype b. Of Hib cases eligible for vaccination, 10% (3/29) were fully vaccinated. For 2009–2016, significant increasing trends were observed for NTHi and Hif infections in the age groups <5 years and ≥60 years and for ampicillin resistance in NTHi. Conclusions This is one of the most comprehensive Hi data analyses since the introduction of Hib vaccines. NTHi and Hif cause an increasing disease burden among elderly patients and infants. Ampicillin resistance in NTHi must be considered in the treatment of invasive Hi infections.

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