Tributyltin oxide affects energy production in the yeast Rhodotorula ferulica, a utilizer of phenolic compounds
Keyword(s):
Rhodotorula ferulica, a yeast able to utilize phenolic compounds, was chosen for evaluating the effects of tributyltin oxide (TBTO) on this utilization. TBTO reduced respiratory capacity when vanillic or benzoic acid was the energy source. The ATP level of the cells was severely affected by 2 μM TBTO. The mitochondrial ATPase was strongly inhibited by 0.5 μM TBTO, whereas the activity of the plasma membrane ATPase was not affected by concentrations of TBTO up to 30 μM. Our data support the hypothesis that the target for TBTO action is the mitochondrial ATPase, resulting in a severe disturbance of the yeast utilization of aromatic compounds.Key words: TBTO, tributyltin, yeast, Rhodotorula ferulica, respiration, ATPase.
1991 ◽
Vol 86
(5)
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pp. 365-371
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The kinetics and divalent cation inhibition of plasma membrane ATPase in the yeast Candida albicans.
1985 ◽
Vol 260
(11)
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pp. 6782-6787
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1985 ◽
Vol 37
(3)
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pp. 189-193
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Keyword(s):
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1980 ◽
Vol 255
(19)
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pp. 9353-9357
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1986 ◽
Vol 168
(3)
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pp. 1254-1257
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