Application des conditions de réaction par transfert de phase à la synthèse d'amino-éthers dérivés du trans phénoxy-2 cyclohexanol

Amino-ethers of trans-2-phenoxycyclohexanol were prepared by methods involving anhydrous conditions (sodium alkoxides in xylene) or phase transfer catalysis conditions (liquid–liquid or solid–liquid two-phase systems). Various factors were optimized. In the liquid–liquid two-phase system, when no catalyst was added, reaction proceeds with comparable or even better yields than with some PTC catalysts, a quaternary salt being formed insitu. It was shown that the deprotonation of ROH takes place at the interface, since there was no OH− extraction in organic medium and the yield depends on the stirring speed. In the presence of Aliquat, the yield does not change with the organic concentration of the catalyst. Statistical correlations obtained between the variations in yield and several other parameters were good.