α-N,N-Dimethylaminoethylferrocene. A nuclear magnetic resonance study relating to stereoselective metalation

1986 ◽  
Vol 64 (4) ◽  
pp. 667-669 ◽  
Author(s):  
Ian R. Butler ◽  
William R. Cullen ◽  
F. Geoffrey Herring ◽  
N. R. Jagannathan

A 1H nmr study of Fe(C5H4CHMeNMe2-η)(C5H4PPh2-η), 2, using the nOe difference experiment, shows a spatial correlation between the —NMe2 group and the site of stereoselective lithiation.


1977 ◽  
Vol 55 (3) ◽  
pp. 447-453 ◽  
Author(s):  
A. K. Cheng ◽  
J. B. Stothers ◽  
C. T. Tan

The bicyclo[2.2.2]octan-2-one and -[3.2.1]octan-6-one skeletons are interconvertible under strongly basic conditions. Their α,α-dimethyl derivatives in tert-Buo−/tert-BuOH at 185 °C undergo very slow interconversion by β-proton abstraction. Using 2H nmr the stereoselectivity of deuterium incorporation at the β-methylene sites was established. The relative reactivities of β-methyl exchange in the [3.2.1] system were also determined. As models for this process, exchange in the α,α,α′,α′-tetramethyl derivatives of the monocyclic ketones, C5–C8, was also studied.







1999 ◽  
Vol 11 (3) ◽  
pp. 871-879 ◽  
Author(s):  
A Taye ◽  
G Klotzsche ◽  
D Michel ◽  
S Mulla-Osman ◽  
R Böttcher


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