Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously

1970 ◽  
Vol 48 (5) ◽  
pp. 299-305 ◽  
Author(s):  
Sumio Nakajima ◽  
D. F. Magee

The actions of glucagon and D-glucose on blood glucose and exocrine pancreatic secretion in response to secretin were studied in unanesthetized dogs with chronic pancreatic fistulas, gastric fistulas, and a gastroenterostomy which diverted gastric acid from the duodenum. Both glucagon and D-glucose, when given intravenously, produced significant and dose-related inhibition of the volume of pancreatic secretion and of the protein, amylase, lipase, and protease outputs. There was a linear inverse relationship between pancreatic enzyme output and blood glucose levels following glucagon or D-glucose infusion. Statistical analysis of the data showed that the slopes of the lines relating blood glucose to amylase, to lipase, and to protease were significantly different from each other, indicating preferential inhibition for amylase.

2018 ◽  
Vol 8 (2) ◽  
pp. 144
Author(s):  
Ria Afrianti

This study aims to determine the effect giving of ethylacetate fraction of leather  purple sweet potato (Ipomoea batatas (L.) Lam, on levels of malondialdehyde (MDA) serum in mice hyperglicemia were induced with streptozocin dose of 50 mg/kgBW. Mice were divided into 5 groups, each group consisting of 3 tails, group I is a negative control, group II is a positive control, group III,IV and V is given ethylacetate fraction a dose of 100 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Ethyl Acetate Fraction leather purple sweet potato given orally for 15 days after the animal is declared hyperglicemia and measurement of blood glucose levels on 5, 10, and 15 day after giving test preparation in animal experiments. On the 16 day throughout the mice were taken serum levels measured malondialdehid. The statistical analysis results showed that giving of ethyl acetate fraction of leather purple sweet potato at a dose of 100 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW can lower blood glucose levels in mice hyperglycemia significantly (p<0.05). Malondialdehid levels on average in each group is 1.35 nmol/ml, 3.00 nmol/ml, 2.72 nmol/ml, 2.20 nmol/ml and 2.61 nmol/ml, the results of statistical analysis showed a decrease in melondialdehid serum levels were significantly (p<0.05), where a dose of 300 mg/kgBW is an effective dose for lowering blood glucose levels followed by decreased levels of malondialdehid which give effect approaching negative control.


2006 ◽  
Vol 31 (03) ◽  
Author(s):  
H Hager ◽  
E Giorni ◽  
A Felli ◽  
B Mora ◽  
M Hiesmayr ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2167-PUB
Author(s):  
KOHEI SURUGA ◽  
TSUYOSHI TOMITA ◽  
MASAKAZU KOBAYASHI ◽  
TADAHIKO MITSUI ◽  
KAZUNARI KADOKURA

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 776-P
Author(s):  
RACHEL BRANDT ◽  
MINSUN PARK ◽  
LAURIE T. QUINN ◽  
MINSEUNG CHU ◽  
YOUNGKWAN SONG ◽  
...  

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