A comparative study of the acute effects of cetamolol (AI-27,303), atenolol, propranolol, and dexpropranolol on blood pressure, sympathetic nerve and ganglion activity of cats
1983 ◽
Vol 61
(7)
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pp. 693-698
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Keyword(s):
The effects of cetamolol (AI-27,303, Betacor®), atenolol, propranolol, and dexpropranolol were evaluated in 36 chloralose–urethane anesthetized cats. Blood pressure, sympathetic nerve discharge, and ganglionic activity (from the superior cervical ganglion) were recorded after the intravenous administration of 2.5, 5.0, and 10 mg/kg doses of the compounds. The results indicate that cetamolol and atenolol decreased blood pressure and discharge in the postganglionic sympathetic nerve and impaired transmission at the level of sympathetic ganglia. Propranolol and dexpropranolol given at the same doses produced a larger decrease in blood pressure, but increased the sympathetic discharge and had no effect on ganglionic spike amplitude.
1989 ◽
Vol 257
(6)
◽
pp. R1506-R1511
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Keyword(s):
1904 ◽
Vol 73
(488-496)
◽
pp. 99-99
1972 ◽
Vol 50
(3)
◽
pp. 263-269
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Keyword(s):
1988 ◽
Vol 254
(2)
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pp. R249-R256
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1977 ◽
Vol 42
(4)
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pp. 331-338
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2001 ◽
Vol 2
(1_suppl)
◽
pp. S120-S124
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1890 ◽
Vol 47
(286-291)
◽
pp. 379-390
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Keyword(s):
1989 ◽
Vol 256
(3)
◽
pp. R739-R750
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2012 ◽
Vol 303
(8)
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pp. H1011-H1021
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