A comparison of the inhibitory effects of somatostatin-14, -25, and -28 on motility of the guinea pig ileum
1986 ◽
Vol 64
(3)
◽
pp. 303-306
◽
Keyword(s):
A number of studies have suggested that somatostatin-14 (SS-14) and somatostatin-28 (SS-28) exhibit a similar spectrum of biological activities but have different potencies. In the present study the effects of SS-14, SS-28, and somatostatin-25 on electrically induced contractions of the guinea pig ileum have been compared. All three peptides exhibited equipotent inhibitory effects. Inhibition was obtained at a threshold concentration less than 10−10 M, with maximal inhibition at 10−7 M and IC50 values of 6.0–6.5 × 10−10 M. The N-terminal 14 amino acid fragment of SS-28 had no effect either on motility, when added alone, or on the actions of SS-28, suggesting that this region of the molecule is not critical for biological activity.
1996 ◽
Vol 10
(1)
◽
pp. 66-69
◽
2003 ◽
Vol 48
(3)
◽
pp. 279-284
◽
1978 ◽
Vol 30
(1)
◽
pp. 525-526
◽
Keyword(s):
2006 ◽
Vol 70
(2)
◽
pp. 489-494
◽
Keyword(s):
Keyword(s):
1982 ◽
Vol 691
(1)
◽
pp. 83-90
◽
1993 ◽
Vol 463
(1)
◽
pp. 565-583
◽
Keyword(s):