G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 ◽  
Vol 74 (10) ◽  
pp. 1095-1110 ◽  
Author(s):  
SSG Ferguson ◽  
L S Barak ◽  
J Zhang ◽  
M G Caron
Keyword(s):  
G Protein ◽  
Receptor Regulation ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals The Role of G Protein-coupled Receptor Kinases in Cancer

2018 ◽  
Vol 14 (2) ◽  
pp. 189-203 ◽  
Author(s):  
Shan Yu ◽  
Litao Sun ◽  
Yufei Jiao ◽  
Leo Tsz On Lee
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

Pleiotropic Role for GRKs and b-Arrestins in Receptor Regulation

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 145-152 ◽  
Author(s):  
SSG Ferguson ◽  
J Zhang ◽  
LS Barak ◽  
MG Caron
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Intracellular Trafficking ◽  
Coated Vesicle ◽  
Receptor Regulation ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Trafficking Molecules ◽  
G Protein Coupled

G protein-coupled receptor kinases and arrestin proteins are well-characterized mediators of agonist-dependent G protein-coupled receptor desensitization. These proteins are now shown to play a dual role in receptor regulation by mediating both receptor uncoupling and sequestration, a process important for receptor resensitization. b-Arrestins bound to phosporylated b2-adrenergic and angiotensin II type 1A receptors act as intracellular trafficking molecules specifically targeting these receptors for dynamin-dependent clathrin-coated vesicle-mediated sequestration.

scholarly journals Role of G protein-coupled receptor kinases in cell migration

2014 ◽  
Vol 27 ◽  
pp. 10-17 ◽  
Author(s):  
Petronila Penela ◽  
Laura Nogués ◽  
Federico Mayor
Keyword(s):  
Cell Migration ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals State of the art paper The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology

2012 ◽  
Vol 6 ◽  
pp. 970-977 ◽  
Author(s):  
Tijana Bojic ◽  
Emina Sudar ◽  
Dimitri Mikhailidis ◽  
Dragan Alavantic ◽  
Esma Isenovic
Keyword(s):  
G Protein ◽  
State Of The Art ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Evidence of an essential role of NHERF1 and NHEF2 in G‐protein coupled receptor regulation of CFTR‐mediated intestinal anion secretion in vivo

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Anurag Kumar Singh ◽  
Brigitte Riederer ◽  
Hugo R. Jonge ◽  
Mark Donowitz ◽  
Edward J. Weinman ◽  
...  
Keyword(s):  
G Protein ◽  
Essential Role ◽  
Receptor Regulation ◽  
G Protein Coupled Receptor ◽  
Anion Secretion ◽  
G Protein Coupled

scholarly journals The role of G protein-coupled receptor kinases in the pathology of malignant tumors

2018 ◽  
Vol 39 (11) ◽  
pp. 1699-1705 ◽  
Author(s):  
Wu-yi Sun ◽  
Jing-jing Wu ◽  
Wen-ting Peng ◽  
Jia-chang Sun ◽  
Wei Wei
Keyword(s):  
G Protein ◽  
Malignant Tumors ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

2015 ◽  
Vol 88 (2) ◽  
pp. 347-356 ◽  
Author(s):  
Janet D. Lowe ◽  
Helen S. Sanderson ◽  
Alexandra E. Cooke ◽  
Mehrnoosh Ostovar ◽  
Elena Tsisanova ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Μ Opioid Receptor ◽  
G Protein Coupled
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