Evolutionarily Conserved Role of G-Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway

2016 ◽  
pp. 301-324
Author(s):  
Dominic Maier ◽  
David R. Hipfner
Keyword(s):  
Signaling Pathway ◽  
G Protein ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
G Protein Coupled Receptor ◽  
Evolutionarily Conserved ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Role of the G-Protein-Coupled Receptor Signaling Pathway in Insecticide Resistance

2019 ◽  
Vol 20 (17) ◽  
pp. 4300 ◽  
Author(s):  
Ting Li ◽  
Nannan Liu
Keyword(s):  
Insecticide Resistance ◽  
Cell Line ◽  
Signaling Pathway ◽  
G Protein ◽  
Cell Lines ◽  
Sf9 Cells ◽  
Camp Production ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

The G-protein-coupled receptor (GPCR) regulated intracellular signaling pathway is known to be involved in the development of insecticide resistance in the mosquito, Culex quinquefasciatus. To elucidate the specific role of each effector in the GPCR regulating pathway, we initially expressed a GPCR, G-protein alpha subunit (Gαs), adenylate cyclase (AC), and protein kinase A (PKA) in insect Spodoptera frugiperda (Sf9) cells and investigated their regulation function on cyclic AMP (cAMP) production and PKA activity. GPCR, Gαs, and AC individually expressed Sf9 cells showed higher cAMP production as the expression of each effector increased. All the effector-expressed cell lines showed increased PKA activity however. Moreover, Sf9 cytochrome P450 gene expression and cell tolerance to permethrin were examined. The relative expression of CYP9A32gene in Sf9 cells tested was significantly increased in all effector-expressed cell lines compared to a control cell line; these effector-expressed cell lines also showed significantly higher tolerance to permethrin. Inhibitor treatments on each effector-expressed cell line revealed that Bupivacaine HCl and H89 2HCl robustly inhibited cAMP production and PKA activity, respectively, resulting in decreased tolerance to permethrin in all cell lines. The synergistic functions of Bupivacaine HCl and H89 2HCl with permethrin were further examined in Culex mosquito larvae, providing a valuable new information for mosquito control strategies.

scholarly journals The Role of G Protein-coupled Receptor Kinases in Cancer

2018 ◽  
Vol 14 (2) ◽  
pp. 189-203 ◽  
Author(s):  
Shan Yu ◽  
Litao Sun ◽  
Yufei Jiao ◽  
Leo Tsz On Lee
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Role of G protein-coupled receptor kinases in cell migration

2014 ◽  
Vol 27 ◽  
pp. 10-17 ◽  
Author(s):  
Petronila Penela ◽  
Laura Nogués ◽  
Federico Mayor
Keyword(s):  
Cell Migration ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals State of the art paper The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology

2012 ◽  
Vol 6 ◽  
pp. 970-977 ◽  
Author(s):  
Tijana Bojic ◽  
Emina Sudar ◽  
Dimitri Mikhailidis ◽  
Dragan Alavantic ◽  
Esma Isenovic
Keyword(s):  
G Protein ◽  
State Of The Art ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals The role of G protein-coupled receptor kinases in the pathology of malignant tumors

2018 ◽  
Vol 39 (11) ◽  
pp. 1699-1705 ◽  
Author(s):  
Wu-yi Sun ◽  
Jing-jing Wu ◽  
Wen-ting Peng ◽  
Jia-chang Sun ◽  
Wei Wei
Keyword(s):  
G Protein ◽  
Malignant Tumors ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

2015 ◽  
Vol 88 (2) ◽  
pp. 347-356 ◽  
Author(s):  
Janet D. Lowe ◽  
Helen S. Sanderson ◽  
Alexandra E. Cooke ◽  
Mehrnoosh Ostovar ◽  
Elena Tsisanova ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Μ Opioid Receptor ◽  
G Protein Coupled

PP-03 Role of G protein coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors

2003 ◽  
Vol 16 (5) ◽  
pp. 593-594
Author(s):  
J. Sanchez ◽  
C. Jimenez-Cervantes ◽  
C. Hahmann ◽  
I. Gerritsen ◽  
J. C. Garcia-Borron
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled ◽  
Homologous Desensitization ◽  
Human And Mouse
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