scholarly journals $$X_1(2900)$$ as a $$\bar{D}_1 K$$ molecule

2021 ◽  
Vol 81 (9) ◽  
Author(s):  
Hao Chen ◽  
Hong-Rong Qi ◽  
Han-Qing Zheng

AbstractThe analyses of the LHCb data on X(2900) in the $$D^- K^+$$ D - K + spectrum are performed. Both dynamically generated and explicitly introduced $$X_1(2900)$$ X 1 ( 2900 ) are considered. The results show that both these two approaches support the interpretation of $$X_1(2900)$$ X 1 ( 2900 ) as a $$\bar{D}_1 K$$ D ¯ 1 K molecular state, with $$J^{P}=1^-$$ J P = 1 - and an iso-singlet interpretation is much more favorable. The effect of triangle singularity on the production of $$X_1(2900)$$ X 1 ( 2900 ) is also discussed, and it is found that it cannot be interpreted as a pure triangle cusp.

Author(s):  
Narendar Dudhipala ◽  
Arjun Narala ◽  
Dinesh Suram ◽  
Karthik Yadav Janga

The objective of this present study is to develop a semisolid dispersion (SSD) of zaleplon with the aid of self-emulsifying lipid based amphiphilic carriers (TPGS E or Gelucire 44/14) addressing the poor solubility of this drug. A linear relationship between the solubility of drug with respect to increase in the concentration of lipid surfactant in aqueous medium resulting in AL type phase diagram was observed from phase solubility studies. Fusion method was employed to obtain semisolid dispersions (SSD) of zaleplon which showed high content uniformity of drug. The absence of chemical interactions between the pure drug, excipients and formulations were conferred by Fourier transmission infrared spectroscopic examinations. The photographic images from polarized optical microscopic studies revealed the change in crystalline form of drug to amorphous or molecular state. The superior dissolution parameters of zaleplon from SSD over pure crystalline drug interpreted from in vitro dissolution studies envisage the ability of these lipid surfactants as solubility enhancers. Further, the caliber of TPGS E or Gelucire 44/14 in encouraging the GI absorption of drug was evident with the higher human effective permeability coefficient and fraction oral dose of drug absorbed from SSD in situ intestinal permeation study. In conclusion, in vivo studies in Wister rats demonstrated an improvement in the oral bioavailability of zaleplon from SSD over control pure drug suspension suggesting the competence of Gelucire 44/14 and TPGS E as conscientious carriers to augment the dissolution rate limited bioavailability of this active


2021 ◽  
Vol 104 (1) ◽  
Author(s):  
Natsumi Ikeno ◽  
Raquel Molina ◽  
Eulogio Oset

2011 ◽  
Vol 704 (4) ◽  
pp. 312-315 ◽  
Author(s):  
Jian-Rong Zhang ◽  
Ming Zhong ◽  
Ming-Qiu Huang
Keyword(s):  

2015 ◽  
Vol 2015 (9) ◽  
pp. 091D01 ◽  
Author(s):  
Takayasu Sekihara
Keyword(s):  

2019 ◽  
Vol 126 (2) ◽  
pp. 147
Author(s):  
Е.И. Войт ◽  
А.Б. Слободюк ◽  
Н.А. Диденко

AbstractThe effect of hydrate number on the structural changes, thermal properties, and ionic (molecular) mobility character in NH_4ZrF_5 ⋅ H_2O, NH_4ZrF_5 ⋅ 0.75H_2O crystal hydrates have been investigated by the methods of IR, Raman, nuclear magnetic resonance (NMR) (^1H, ^19F, including ^19F MAS), and TG-DTA spectroscopy. Differences in crystal hydrate structures—anion structure, molecular state of water, and O–H⋅⋅⋅F, N–H⋅⋅⋅F hydrogen bond strengths—have been corroborated by IR and Raman spectroscopy data. Isotropic chemical shifts of magnetic inequivalent positions have been determined and attributed to crystal structures of the studied compounds by the method of ^19F MAS NMR. It has been established that the removal of water molecules from NH_4ZrF_5 ⋅ H_2O and NH_4ZrF_5 ⋅ 0.75H_2O results in the transformation of chain or layered structures accompanied by the increase of the number of bridge bonds while retaining or increasing the dimensionality of the anion structural motif. According to the ^1H NMR data, the NH $$_{4}^{ + }$$ cation diffusion in NH_4ZrF_5 occurs only in the temperature range of 370–520 K.


2017 ◽  
Vol 10 (4-5) ◽  
pp. 531-539 ◽  
Author(s):  
N. F. Goldshleger ◽  
A. S. Lobach ◽  
N. N. Dremova ◽  
M. A. Lapshina ◽  
A. M. Kolesnikova ◽  
...  

1994 ◽  
Vol 49 (11) ◽  
pp. 5773-5778 ◽  
Author(s):  
N. N. Achasov ◽  
A. A. Kozhevnikov
Keyword(s):  

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